Results 91 to 100 of about 114,798 (264)

Insect‐Derived Bioactives for Glycemic Control and Gut Health: A Review

Food Frontiers, EarlyView.
Insect‐derived bioactive compounds (e.g., peptides, polysaccharides) effectively regulate blood glucose through dual mechanisms: directly inhibiting carbohydrate‐digesting enzymes and glucose transporters, and indirectly modulating gut microbiota to enhance intestinal barrier integrity.
Chaoyi Lv, Yuanyuan Huang, Mokhtar Dabbour, Benjamin Kumah Mintah, Ronghai He, Haile Ma   +5 more
wiley   +1 more source

Mechanisms underlying bone loss associated with gut inflammation [PDF]

, 2019
Patients with gastrointestinal diseases frequently suffer from skeletal abnormality, characterized by reduced bone mineral density, increased fracture risk, and/or joint inflammation.
Abu-Amer, Yousef, Arra, Manoj, Ke, Ke
core   +2 more sources

Aldo-keto reductase 1B7 is a target gene of FXR and regulates lipid and glucose homeostasis[S]

Journal of Lipid Research, 2011
Aldo-keto reductase 1B7 (AKR1B7) is proposed to play a role in detoxification of by-products of lipid peroxidation. In this article, we show that activation of the nuclear receptor farnesoid X receptor (FXR) induces AKR1B7 expression in the liver and ...
Xuemei Ge, Liya Yin, Huiyan Ma, Tiangang Li, John Y.L. Chiang, Yanqiao Zhang   +5 more
doaj   +1 more source

Loss of small heterodimer partner expression in the liver protects against dyslipidemias⃞

Journal of Lipid Research, 2009
Multiple studies suggest increased conversion of cholesterol to bile acids by cholesterol 7α-hydroxylase (CYP7A1) protects against dyslipidemia and atherosclerosis.
Helen B. Hartman, KehDih Lai, Mark J. Evans   +2 more
doaj   +1 more source

Regulation of N-Myc downstream regulated gene 2 by bile acids [PDF]

, 2017
Here we report that bile acid chenodeoxycholic acid (CDCA) and synthetic farnesoid X receptor (FXR) agonist GW4064 robustly induced tumor suppressor N-Myc downstream regulated gene 2 (NDRG2) expression in human hepatoma cells and primary hepatocytes ...
Donate, Yolanda, Haro Bautista, Diego, Langhi, Cédric, Marrero González, Pedro F., Pedraz Cuesta, Elena, Rodríguez Rubio, Joan Carles   +5 more
core   +1 more source

FARNESOID X RECEPTOR AND REPRODUCTION

Receptors & Clinical Investigation, 2015
Farnesoid X alpha receptors (FXRα or NR1H4) are present in male and female reproductive tissues. The aim of the present review is to describe those actions of the most relevant ligands of FXRα on reproduction and the interaction of this receptor with other nuclear receptors, for understanding the possible role of FXRα in reproductive events.
openaire   +1 more source

High temperature and humidity in the environment disrupt bile acid metabolism, the gut microbiome, and GLP-1 secretion in mice

Communications Biology
High temperature and humidity in the environment are known to be associated with discomfort and disease, yet the underlying mechanisms remain unclear.
Song Chen, Zongren Hu, Jianbang Tang, Haipeng Zhu, Yuhua Zheng, Jiedong Xiao, Youhua Xu, Yao Wang, Yi Luo, Xiaoying Mo, Yalan Wu, Jianwen Guo, Yongliang Zhang, Huanhuan Luo   +13 more
doaj   +1 more source

Hepatic bile acids and bile acid-related gene expression in pregnant and lactating rats [PDF]

, 2013
Background. Significant physiological changes occur during pregnancy and lactation. Intrahepatic cholestasis of pregnancy (ICP) is a liver disease closely related to disruption of bile acid homeostasis.
Dan Zhang, Hong M. Xie, Jie Liu, Qiong N. Zhu, Yuan F. Lu   +4 more
core   +1 more source

Promoter DNA methylation of farnesoid X receptor and pregnane X receptor modulates the intrahepatic cholestasis of pregnancy phenotype. [PDF]

PLoS ONE, 2014
The intrahepatic cholestasis of pregnancy (ICP) is a multifactorial liver disorder which pathogenesis involves the interplay among abnormal bile acid (BA) levels, sex hormones, environmental factors, and genetic susceptibility.
Romina Cabrerizo, Gustavo O Castaño, Adriana L Burgueño, Tomas Fernández Gianotti, María Mora Gonzalez Lopez Ledesma, Diego Flichman, Carlos J Pirola, Silvia Sookoian   +7 more
doaj   +1 more source

Role of Farnesoid X Receptor in the Pathogenesis of Respiratory Diseases

Canadian Respiratory Journal, 2020
Farnesoid X receptor (FXR) is a bile acid receptor encoded by the Nr1h4 gene. FXR plays an important role in maintaining the stability of the internal environment and the integrity of many organs, including the liver and intestines. The expression of FXR
Jin-nan Wu, Jian-rong Chen, Jin-liang Chen   +2 more
doaj   +1 more source