Results 131 to 140 of about 114,798 (264)

Irisin Is Controlled by Farnesoid X Receptor and Regulates Cholesterol Homeostasis

Frontiers in Pharmacology, 2019
ObjectiveThe aim of this study was to investigate whether the nuclear receptor farnesoid X receptor (FXR) could regulate FNDC5/Irisin expression and the role of Irisin in hyperlipidemia and atherosclerosis in ApoE-/- mice.Methods and ResultsWe treated ...
Hong Li, Hong Li, Jing Shen, Jing Shen, Tong Wu, Tong Wu, Jiangying Kuang, Jiangying Kuang, Qinhui Liu, Shihai Cheng, Shihai Cheng, Shiyun Pu, Shiyun Pu, Lei Chen, Lei Chen, Rui Li, Rui Li, Yanping Li, Yanping Li, Min Zou, Zhiyong Zhang, Wei Jiang, Aijuan Qu, Jinhan He, Jinhan He   +24 more
doaj   +1 more source

Dysregulation of Farnesoid X Receptor on Neutrophil Homeostasis Exacerbates Intestinal Inflammation via the mTORC1‐Glycolysis Signaling Pathway

MedComm, Volume 7, Issue 2, February 2026.
FXR signaling attenuates neutrophil functions by suppressing mTORC1 activity to ameliorate intestinal mucosal inflammation in IBD. In the inflamed intestinal mucosa, FXR expression is markedly diminished in neutrophils, attenuating its restraint on the mTORC1‐glycolysis axis. This metabolic shift toward elevated glycolysis augments neutrophil migratory
Dengfeng Kang, Ai Li, Xiangqi Xie, Han Liu, Liang Chen, Zhongsheng Feng, Xiang Gao, Han Gao, Xiaohan Wu, Huiying Lu, Xiaoyu Li, Jinghan Hua, Long Ju, Haifeng Lian, Xue Li, Zhanju Liu   +15 more
wiley   +1 more source

Expression, purification, crystallization and preliminary X-ray diffraction analysis of conjugated bile salt hydrolase from Bifidobacterium longum [PDF]

, 2004
Conjugated bile salt hydrolase (BSH) catalyses the hydrolysis of the amide bond that conjugates bile acids to glycine and to taurine. The BSH enzyme from Bifidobacterium longum was overexpressed in Escherichia coli BL21(DE3), purified and crystallized ...
Brannigan, J A, Dodson, G G, Kumar, R S, Prabhune, A, Pundle, A, Suresh, C G   +5 more
core   +1 more source

Bile Acid Binding Resins Improve Glucagon Receptor Agonist‐Mediated Weight Loss in Diet‐Induced Obese Mice

Obesity, Volume 34, Issue 2, Page 428-438, February 2026.
ABSTRACT Objective Glucagon‐receptor (GCGR) agonism reguglates bile acid (BA) metabolism and promotes weight loss in diet‐induced obese (DIO) mice. Thus, we hypothesized that BA signaling contributes to GCGR‐stimulated weight loss. Methods To test this hypothesis, we utilized BA‐binding resins (BARs; colesevelam [Colsv] and cholestyramine [Cstyr]) to ...
Teayoun Kim, Mackenzie J. Pearson, Huixian Hong, Shelly Nason, Khadija Seck, Jessica Antipenko, Natalie Presedo, Richard DiMarchi, William C. Roell, Kirk Habegger   +9 more
wiley   +1 more source

Nuclear farnesoid X receptor attenuates acute kidney injury through fatty acid oxidation.

Kidney International, 2022
Sujuan Xu, P. Jia, Yi Fang, Jifu Jin, Zhaoxing Sun, Weiran Zhou, Jie Li, Yunlu Zhang, Xiao-yan Wang, T. Ren, Zhouping Zou, Xiaoqiang Ding   +11 more
semanticscholar   +1 more source

Circulating Profiles of the Bile Acid Metabolomics in Patients With Polycystic Ovary Syndrome Treated With Metformin or Canagliflozin

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 2, February 2026.
ABSTRACT Objective Bile acids are indispensable modulators in the development of polycystic ovary syndrome (PCOS). Our previous study identified that metformin and canagliflozin have similar efficacy in patients with PCOS combined with insulin resistance (IR).
Qi Yan, Meili Cai, Nan Wang, Wenhao Wu, Hua Zhang, Yikun Zhu, Jing Luo, Manna Zhang, Jin Li   +8 more
wiley   +1 more source

High folic acid consumption leads to pseudo-MTHFR deficiency, altered lipid metabolism, and liver injury in mice. [PDF]

, 2015
Increased consumption of folic acid is prevalent, leading to concerns about negative consequences. The effects of folic acid on the liver, the primary organ for folate metabolism, are largely unknown.
Best, A, Caudill, MA, Christensen, KE, Deng, L, Greene, ND, Leung, KY, Lévesque, N, Malysheva, OV, Mikael, LG, Rozen, R, Wu, Q   +10 more
core   +1 more source

Allosteric modulation of the farnesoid X receptor by a small molecule

Scientific Reports, 2018
The bile acid activated transcription factor farnesoid X receptor (FXR) regulates numerous metabolic processes and is a rising target for the treatment of hepatic and metabolic disorders.
Matthias Gabler, Jan Kramer, Jurema Schmidt, Julius Pollinger, Julia Weber, Astrid Kaiser, Frank Löhr, Ewgenij Proschak, Manfred Schubert-Zsilavecz, Daniel Merk   +9 more
doaj   +1 more source

Non‐Response to Obeticholic Acid Is Associated With Heightened Risks of Developing Clinical Events in Primary Biliary Cholangitis

Alimentary Pharmacology &Therapeutics, Volume 63, Issue 4, Page 494-506, February 2026.
In a multi‐centre study of obeticholic acid in primary biliary cholangitis, 45% discontinued the drug over 4 years, with 11% moving to combination therapy (fibrates). Of those continuing, response rates increased from 37% (1 year) to 55% (4 years). Non‐response at 12 months and cirrhosis were independent predictors of liver‐related events.
Nadir Abbas, Rachel Smith, Ellina Lytvyak, Miki Scaravaglio, Neil Halliday, Amal Almahroos, Nadia Eden, Diane Lloyd‐Madden, Sanchit Sharma, James Ferguson, Jessica K. Dyson, Douglas Thorburn, David Jones, Aldo J. Montano‐Loza, Marco Carbone, Pietro Invernizzi, George Mells, Emma L. Culver, Palak J. Trivedi   +18 more
wiley   +1 more source

FXR expression is associated with dysregulated glucose and lipid levels in the offspring kidney induced by maternal obesity [PDF]

, 2015
© 2015 Glastras et al. Background: Maternal obesity is associated with dysregulation of glucose and lipid metabolism with consequent exposure of the fetus to an abnormal metabolic milieu.
Chen, H, Glastras, SJ, Pollock, CA, Saad, S, Wong, MG, Zaky, A, Zhang, J   +6 more
core   +2 more sources