Results 101 to 110 of about 1,757 (116)

Abstract 395: Farnesyl diphosphate farnesyltransferase induces metastasis via upregulating secreted phosphoprotein 1 in non-small cell lung cancer.

Cancer Research, 2013
Abstract Identifying cancer progression associated genes that predicting patient outcome might provide opportunities for developing better therapeutic strategies for lung cancer patients. In the present study, we investigated whether farnesyl diphosphate farnesyltransferase (FDFT1), an enzyme of mevalonate pathway, is a potential ...
Yi-Fang Yang, Yi-Hua Jan, Michael Hsiao
openaire   +1 more source

Abstract 4612: Overexpression of cholesterol metabolism regulatory gene farnesyl diphosphate farnesyltransferase is associated with poor prognosis of non-small cell lung cancer patient and promotes metastasis through feedback regulation of SPP1-PI3K-AKT signaling pathway

Cancer Research, 2012
Abstract Lung cancer is the leading cause of the human cancer-related death in the world and non-small cell lung cancer (NSCLC) accounts for up to 80 % of those patients. Cholesterol metabolism is especially active in cancer cells, whereas cholesterol synthesis inhibition has been show to reduce tumor cell growth.
Yi-Fang Yang, Hong-Yuan Tsia, Chien-Hsin Lee, Christina H Lim, Michael Hsiao   +4 more
openaire   +1 more source

FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE 1 IS ASSOCIATED WITH THE GROWTH OF RENAL CANCER : ASSOCIATION WITH ANTICANCER EFFECT OF STATIN

Journal of Urology, 2009
Hidekazu Koike, Yoshitaka Sekine, Yasuyuki Morikawa, Yosuke Furuya, Hiroshi Matsui, Kazuhiro Suzuki   +5 more
openaire   +1 more source

1032 FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE 1 IS ASSOCIATED WITH THE GROWTH OF RENAL CANCER: ASSOCIATION WITH ANTICANCER EFFECT OF STATIN

European Urology Supplements, 2009
H. Koike, Y. Sekine, Y. Morikawa, Y. Furuya, M. Matsui, K. Suzuki   +5 more
openaire   +1 more source

Histidylbenzylglycinamides: A Novel Class of Farnesyl Diphosphate-Competitive Peptidic Farnesyltransferase Inhibitors

2001
Judith S. Sebolt-Leopold, Daniele M. Leonard, W. R. Leopold   +2 more
openaire   +1 more source

ASSOCIATION BETWEEN COMMON SEQUENCE VARIANTS IN THE FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE 1 (FDFT1) GENE AND THE PROSTATE CANCER RISK IN THE JAPANESE POPULATION

Journal of Urology, 2009
Yuji Fukuma, Hiroshi Matsui, Tatsuya Hamano, Nobuaki Ohtake, Seiji Nakata, Kazuhiro Suzuki   +5 more
openaire   +1 more source

A versatile photoactivatable probe designed to label the diphosphate binding site of farnesyl diphosphate utilizing enzymes

Bioorganic and Medicinal Chemistry, 2009
David Shintani, Claudia Schmidt-Dannert, Mark Distefano   +2 more
exaly  

An enzyme-coupled continuous fluorescence assay for farnesyl diphosphate synthases

Analytical Biochemistry, 2012
Mark Distefano
exaly  

Cocrystal Structure of Protein Farnesyltransferase Complexed with a Farnesyl Diphosphate Substrate†,‡

Biochemistry, 1998
Patrick Casey, Stephen Long
exaly  

Synthesis, Properties, and Applications of Diazotrifluropropanoyl‐Containing Photoactive Analogs of Farnesyl Diphosphate Containing Modified Linkages for Enhanced Stability

Chemical Biology and Drug Design, 2010
Mark Distefano, Fernando Lopez Gallego
exaly