Results 111 to 120 of about 2,830 (142)

METTL7A inhibits progression of colorectal cancer through the SREBP1 / FDFT1 / SQLE / CYP51A1 / cholesterol metabolic pathway. [PDF]

Cell Oncol (Dordr)
Li S, Chi X, Li X, Li W, Yang H, Cao W, Zhao Y, Zhang X, Meng R, Du G, Zhang D, Wang J.   +11 more
europepmc   +1 more source

EMC2 promotes triple negative breast cancer growth by protecting FDFT1 from endoplasmic reticulum associated degradation to impair ferroptosis susceptibility. [PDF]

Oncogene
Dong X, Dai H, Yao L, Lin Y, Wang Y, Li Y, Zhang X, Zhou L, Lu J, Yin W.   +9 more
europepmc   +1 more source

NSC777201 exhibits anticancer activity against colorectal cancer cells by inducing multiple types of cell death. [PDF]

Cancer Cell Int
Ho HH, Wang SC, Huang HS, Yang PM.
europepmc   +1 more source

IL-33-mediated mast cell and eosinophil function requires isoprenylation. [PDF]

Front Immunol
Burchett JR, Kotha A, Davis DT, Jackson KG, Dailey JM, Maldonado TD, Haque TT, Hussain ZY, Ching JM, Frischmeyer-Guerrerio P, Sebti SM, Ryan JJ.   +11 more
europepmc   +1 more source

Broadening the Utility of Farnesyltransferase-Catalyzed Protein Labeling Using Norbornene-Tetrazine Click Chemistry. [PDF]

Bioconjug Chem
Auger SA, Venkatachalapathy S, Suazo KFG, Wang Y, Sarkis AW, Bernhagen K, Justyna K, Schaefer JV, Wollack JW, Plückthun A, Li L, Distefano MD.   +11 more
europepmc   +1 more source

Ubiquitin specific peptidase 32 acts as an oncogene in epithelial ovarian cancer by deubiquitylating farnesyl-diphosphate farnesyltransferase 1

Ubiquitin specific peptidase 32 acts as an oncogene in epithelial ovarian cancer by deubiquitylating farnesyl-diphosphate farnesyltransferase 1
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Ubiquitin specific peptidase 32 acts as an oncogene in epithelial ovarian cancer by deubiquitylating farnesyl-diphosphate farnesyltransferase 1

Biochemical and Biophysical Research Communications, 2021
Epithelial ovarian cancer (EOC) is the seventh most common cancer worldwide and the deadliest gynecological malignancy because of its aggressiveness and high recurrence rate. To discover new therapeutic targets for EOC, we combined public EOC microarray datasets with our previous in vivo shRNA screening dataset.
Aya Nakae, Michiko Kodama, Kenjiro Sawada   +2 more
exaly   +3 more sources

Analogs of farnesyl diphosphate alter CaaX substrate specificity and reactions rates of protein farnesyltransferase [PDF]

Bioorganic and Medicinal Chemistry Letters, 2016
Attempts to identify the prenyl-proteome of cells or changes in prenylation following drug treatment have used 'clickable' alkyne-modified analogs of the lipid substrates farnesyl- and geranylgeranyl-diphosphate (FPP and GGPP). We characterized the reactivity of four alkyne-containing analogs of FPP with purified protein farnesyltransferase and a small
Benjamin C Jennings, Mark D Distefano, Carol A Fierke   +2 more
exaly   +3 more sources

Farnesyl Diphosphate Analogues with Aryl Moieties Are Efficient Alternate Substrates for Protein Farnesyltransferase [PDF]

Biochemistry, 2012
Farnesylation is an important post-translational modification essential for the proper localization and function of many proteins. Transfer of the farnesyl group from farnesyl diphosphate (FPP) to proteins is catalyzed by protein farnesyltransferase (FTase).
Carol A Fierke
exaly   +3 more sources

Farnesyl‐diphosphate farnesyltransferase 1 regulates hepatitis C virus propagation

FEBS Letters, 2014
To identify the novel genes involved in lipid metabolism and lipid droplet formation that may play important roles in Hepatitis C virus (HCV) propagation, we have screened the small interfering RNA library using cell culture derived HCV (HCVcc)‐infected cells.
Park, Eun-Mee, Nguyen, Lam N., Lim, Yun-Sook, Hwang, Soon B.   +3 more
exaly   +3 more sources