Results 141 to 150 of about 5,098 (167)

Protein farnesyltransferase inhibitors interfere with farnesyl diphosphate binding by rubber transferase

European Journal of Biochemistry, 2003
Rubber transferase, a cis‐prenyltransferase, catalyzes the addition of thousands of isopentenyl diphosphate (IPP) molecules to an allylic diphosphate initiator, such as farnesyl diphosphate (FPP, 1), in the presence of a divalent metal cofactor. In an effort to characterize the catalytic site of rubber transferase, the effects of two types of protein ...
Christopher J D, Mau, Sylvie, Garneau, Andrew A, Scholte, Jennifer E, Van Fleet, John C, Vederas, Katrina, Cornish   +5 more
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Cocrystal Structure of Protein Farnesyltransferase Complexed with a Farnesyl Diphosphate Substrate^,

Biochemistry, 1998
Protein farnesyltransferase (FTase) catalyzes the transfer of the hydrophobic farnesyl group from farnesyl diphosphate (FPP) to cellular proteins such as Ras at a cysteine residue near their carboxy-terminus. This process is necessary for the subcellular localization of these proteins to the plasma membrane and is required for the transforming activity
S B, Long, P J, Casey, L S, Beese
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Abstract 395: Farnesyl diphosphate farnesyltransferase induces metastasis via upregulating secreted phosphoprotein 1 in non-small cell lung cancer.

Cancer Research, 2013
Abstract Identifying cancer progression associated genes that predicting patient outcome might provide opportunities for developing better therapeutic strategies for lung cancer patients. In the present study, we investigated whether farnesyl diphosphate farnesyltransferase (FDFT1), an enzyme of mevalonate pathway, is a potential ...
Yi-Fang Yang, Yi-Hua Jan, Michael Hsiao
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Abstract 4612: Overexpression of cholesterol metabolism regulatory gene farnesyl diphosphate farnesyltransferase is associated with poor prognosis of non-small cell lung cancer patient and promotes metastasis through feedback regulation of SPP1-PI3K-AKT signaling pathway

Cancer Research, 2012
Abstract Lung cancer is the leading cause of the human cancer-related death in the world and non-small cell lung cancer (NSCLC) accounts for up to 80 % of those patients. Cholesterol metabolism is especially active in cancer cells, whereas cholesterol synthesis inhibition has been show to reduce tumor cell growth.
Yi-Fang Yang, Hong-Yuan Tsia, Chien-Hsin Lee, Christina H Lim, Michael Hsiao   +4 more
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Ras farnesylation as a target for novel antitumor agents: Potent and selective farnesyl diphosphate analog inhibitors of farnesyltransferase

Drug Development Research, 1995
AbstractProtein prenylation is increasingly recognized as an important mechanism by which functional association of proteins to membranes is mediated. Ras proteins, regulators of cell proliferation and differentiation, are among the proteins that undergo farnesylation, one of the two prenylation modifications known.
Veeraswamy Manne, Carolyn S. Ricca, Johnni Gullo Brown, Anne V. Tuomari, Ning Yan, Dinesh Patel, Robert Schmidt, Mark J. Lynch, Carl P. Ciosek, Joan M. Carboni, Simon Robinson, Eric M. Gordon, Mariano Barbacid, Bernd R. Seizinger, Scott A. Biller   +14 more
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A New Class of Highly Potent Farnesyl Diphosphate-Competitive Inhibitors of Farnesyltransferase

Journal of Medicinal Chemistry, 1998
T, Aoyama, T, Satoh, M, Yonemoto, J, Shibata, K, Nonoshita, S, Arai, K, Kawakami, Y, Iwasawa, H, Sano, K, Tanaka, Y, Monden, T, Kodera, H, Arakawa, I, Suzuki-Takahashi, T, Kamei, K, Tomimoto   +15 more
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1032 FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE 1 IS ASSOCIATED WITH THE GROWTH OF RENAL CANCER: ASSOCIATION WITH ANTICANCER EFFECT OF STATIN

European Urology Supplements, 2009
H. Koike, Y. Sekine, Y. Morikawa, Y. Furuya, M. Matsui, K. Suzuki   +5 more
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Farnesyl-diphosphate farnesyltransferase

1997
Dietmar Schomburg, Dörte Stephan
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ASSOCIATION BETWEEN COMMON SEQUENCE VARIANTS IN THE FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE 1 (FDFT1) GENE AND THE PROSTATE CANCER RISK IN THE JAPANESE POPULATION

Journal of Urology, 2009
Yuji Fukuma, Hiroshi Matsui, Tatsuya Hamano, Nobuaki Ohtake, Seiji Nakata, Kazuhiro Suzuki   +5 more
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Histidylbenzylglycinamides: A Novel Class of Farnesyl Diphosphate-Competitive Peptidic Farnesyltransferase Inhibitors

2001
Judith S. Sebolt-Leopold, Daniele M. Leonard, W. R. Leopold   +2 more
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