Farnesyl-diphosphate farnesyltransferase

Results 61 to 70 of about 2,830 (142)

, 2017
The three RAS oncogenes make up the most frequently mutated gene family in human cancer. The well-validated role of mutationally activated RAS genes in driving cancer development and growth has stimulated comprehensive efforts to develop therapeutic ...
Der, Channing J, Papke, Bjoern
core +2 more sources

Synthesis of Novel Isoprenoid Diphosphate Analogs as Chemical Tools to Investigate Protein Geranylgeranylation [PDF]

, 2013
Many proteins require prenylation in order to be biologically functional. Some such proteins include the small Ras and Rho GTPase superfamilies, nuclear lamins A and B, and the kinesin motor proteins CENP-E and F.
Temple, Kayla Jo
core +1 more source

REDEFINING THE SCOPE OF PRENYLATION: DISCOVERY OF “FORBIDDEN” SUBSTRATE RECOGNITION AND DEVELOPMENT OF METHODS UTILIZING PRENYLATED PROTEINS [PDF]

, 2018
Post-translational modifications play a central role in controlling biological function and cell behavior through changes in protein structure, activity, and localization.
Blanden, Melanie Jane
core +1 more source

Induction And Regulation Of Autophagy By Novel Prenylation Inhibitors In Sts-26t Malignant Peripheral Nerve Sheath Tumor (mpnst) Cells [PDF]

, 2010
Prenylation pathways have been targeted via several different compounds that inhibit farnesyl transferase (FTase) and/or geranylgeranyl transferase (GGTase) enzymes in many cellular and animal models of cancer.
Sane, Komal Madhukar
core +1 more source

Mechanism of Catalysis and Inhibition of Mammalian Protein Farnesyltransferase. [PDF]

, 2007
Mammalian protein farnesyltransferase (FTase) catalyzes the transfer of a 15-carbon prenyl group from farnesyl diphosphate (FPP) to a cysteine residue near the carboxyl terminus of many proteins, including several key molecules involved in signal ...
Pais, June E.
core

Molecular Recognition of Substrates by Protein Farnesyltransferase and Geranylgeranyltransferase-I. [PDF]

Prenylation is an important post-translational modification that targets proteins to the cellular membrane. Farnesyltransferase (FTase) catalyzes the attachment of the 15-carbon farnesyl moiety from farnesyldiphosphate to a cysteine near the C-terminus ...
Lamphear, Corissa L.
core

Pre-loading of chlorophyll synthase with tetraprenyl diphosphate is an obligatory step in chlorophyll biosynthesis [PDF]