Screening of prenyldiphosphate mimetics for their potential to inhibit 4-hydroxybenzoate oligoprenyl transferase [PDF]
, 2017 4-Hydroxybenzoat-Oligoprenyl-Transferase (UbiA-Prenyltransferase) ist ein wichtiges Enzym in der Ubichinon-Biosynthese von E. coli. Es katalysiert die Prenylierung von 4-Hydroxybenzoat (4-HB) an Position 3 zu 3-Oligoprenyl-4-Hydroxybenzoat ...
Msonga, Amina
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ISOPRENOID ANALOGS AS CHEMICAL GENETIC TOOLS TO PROVIDE INSIGHTS INTO FARNESYL TRANSFERASE TARGET SELECTION AND CELLULAR ACTIVITY [PDF]
, 2006 Protein farnesylation is an essential post-translational modification required for the function of numerous cellular proteins including the oncoprotein Ras. The farnesyl transferase (FTase) catalyzed reaction is unique because farnesyl diphosphate (FPP),
Troutman, Jerry
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Genomic variation in myeloma: design, content, and initial application of the Bank On A Cure SNP Panel to detect associations with progression-free survival [PDF]
, 2008 Background We have engaged in an international program designated the Bank On A Cure, which has established DNA banks from multiple cooperative and institutional clinical trials, and a platform for examining the association of genetic variations with ...
Brian Van Ness +59 more
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EXPANDING THE POTENTIAL PRENYLOME: PRENYLATION OF SHORTENED TARGET SUBSTRATES BY FTASE AND DEVELOPMENT OF FRET-BASED SYSTEM FOR DETECTING POTENTIALLY “SHUNTED” PROTEINS [PDF]
, 2020 Protein prenylation is a posttranslational modification involving the attachment of a C15 or C20 isoprenoid group to a cysteine residue near the C-terminus of the target substrate by protein farnesyltransferase (FTase) or protein ...
Ashok, Sudhat
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Propranolol treatment of infantile hemangioma endothelial cells: A molecular analysis [PDF]
, 2014 Infantile hemangiomas (IHs) are non-malignant, largely cutaneous vascular tumors affecting approximately 5–10% of children to varying degrees. During the first year of life, these tumors are strongly proliferative, reaching an average size ranging from 2
AMAYA, CLARISSA +10 more
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Frontiers in PharmacologyIntroductionValproic acid (VPA) constitutes a branched-chain, short-chain fatty acid that serves as an antiepileptic medication. It has been increasingly recognized that VPA has presented potential anti-tumor properties, including breast cancer. However,
Shuxian Zhang +6 more
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Molecular signatures associated with the treatment of triple-negative MDA-MB231 breast cancer cells with the histone deacetylase inhibitors JAHA and SAHA [PDF]
, 2017 Jay Amin Hydroxamic Acid (JAHA; N8-ferrocenylN1-hydroxy-octanediamide) is a ferrocene-containing analogue of the histone deacetylase inhibitor (HDACi) suberoylanilide hydroxamic acid (SAHA).
Claudio Luparello +10 more
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Characterization Of Protein Prenyltransferases And Protein Prenylation In Plasmodium Falciparum [PDF]
, 2004 Malaria kills at least one million people each year, mostly children - a death every 30 seconds. Almost one half of the world population is at risk from malaria.
DaSilva, Thiago Gaspar
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Insights into the Sesquiterpenoid Pathway by Metabolic Profiling and De novo Transcriptome Assembly of Stem-Chicory (Cichorium intybus Cultigroup "Catalogna") [PDF]
, 2016 Stem-chicory of the "Catalogna" group is a vegetable consumed for bitter-flavored stems. Type and levels of bitter sesquiterpene lactones (STLs) participate in conferring bitterness in vegetables.
Alessandro Schiappa +12 more
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Protein farnesyltransferase and protein prenylation in Plasmodium falciparum [PDF]
, 2002 Comparison of the malaria parasite and mammalian protein prenyltransferases and their cellular substrates is important for establishing this enzyme as a target for developing antimalarial agents.
Allen, Charles M. +6 more
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