Results 31 to 40 of about 2,830 (142)
Pharmacogenetics of osteoporosis: a pathway analysis of the genetic influence on the effects of antiresorptive drugs [PDF]
, 2022 Osteoporosis is a skeletal disorder defined by a decreased bone mineral density (BMD) and an increased susceptibility to fractures. Bisphosphonates and selective oestrogen receptor modulators (SERM) are among the most widely used drugs. They inhibit bone
Hernández Hernández, José Luis +4 more
core +1 more source
synergistic cytoreductive effects of zoledronic acid and radiation on breast cancer cells [PDF]
, 2006 Introduction Bisphosphonates are mostly used in the treatment of bone metastases. They have been shown to act synergistically with other chemotherapeutic agents. It is not known, however, whether similar synergistic effects exist with radiation on breast
A Ugur Ural +30 more
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, 2021 Additional file 4: Table S1. The sequences of oligo dT and primers used in this study.
Zhao, Ruiyang +7 more
openaire +1 more source
, 2008 An abundantly growing body of literature implicates conjugation of SUMO in the regulation of many proteins and processes, yet the regulation of SUMO pathways is poorly understood.
Brian J Wilson
core +2 more sources
Molecular actions of hypocholesterolaemic compounds from edible mushrooms [PDF]
, 2018 Cholesterol levels are strictly regulated to maintain its homeostasis; therefore, if it is not absorbed with the diet, the cholesterol biosynthetic pathway is enhanced and vice versa.
Gil-Ramírez, Alicia +2 more
core +1 more source
FDFT1 inhibits macrophage M1 polarization and promotes colorectal cancer progression
陆军军医大学学报Objective To screen the targets related to the metabolic enzymes involved in the cholesterol synthesis pathway that inhibits the polarization of macrophages towards M1 phenotype, and verify the intervention effects and underlying mechanisms in ...
GAO Yuan, HUANG Yulan, ZHAO Kun
doaj +1 more source
Animals, 2018 Grape pomace (GPO), the main by-product of the wine making process, is a rich source of polyphenols with potent antioxidant properties. Recently, GPO has emerged as a potential feed additive in livestock nutrition, with several reports describing its ...
Marco Iannaccone +7 more
doaj +1 more source
Preventing Farnesylation of the Dynein Adaptor Spindly Contributes to the Mitotic Defects Caused by Farnesyltransferase Inhibitors [PDF]
, 2015 The clinical interest in farnesyltransferase inhibitors (FTIs) makes it important to understand how these compounds affect cellular processes involving farnesylated proteins.
Andres, Douglas A. +8 more
core +3 more sources
Viral MicroRNAs Repress the Cholesterol Pathway, and 25-Hydroxycholesterol Inhibits Infection
mBio, 2017 From various screens, we found that Kaposi’s sarcoma-associated herpesvirus (KSHV) viral microRNAs (miRNAs) target several enzymes in the mevalonate/cholesterol pathway.
Anna K. P. Serquiña +3 more
doaj +1 more source
Synthesis of a GGTase Substrate for Possible Oncogenesis Identification and Inhibition [PDF]
, 2021 Geranylgeranyl transferase (GGTase) is an enzyme involved in the prenylation of many proteins, including Ras proteins. Prenylation is the addition of a hydrophobic hydrocarbon chain to a molecule.
Dammar, Haley
core +1 more source