Results 11 to 20 of about 1,757 (116)
Biochemical and Biophysical Research CommunicationsCancer poses a significant risk to human well-being. Among the crucial characteristics of cancer is metabolic reprogramming. To meet the relentless metabolic needs, cancer cells enhance cholesterol metabolism within the adverse tumor microenvironment.
Wang Guojuan, Wenyan Yu, Nanxin Li
exaly +3 more sources
Advanced ScienceTargeting cholesterol metabolism is a novel direction for tumor therapy. Unfortunately, the current use of statins for hepatocellular carcinoma (HCC) is controversial.
Dong Cai +9 more
doaj +2 more sources
Proteomic Analysis of the Effects of Shenzhu Tiaopi Granules on Model Rats with Type 2 Diabetes Mellitus [PDF]
Diabetes, Metabolic Syndrome and ObesityJin-Dong Zhao,1– 3 Zhao-Hui Fang1– 3 1Department of Endocrinology Two, the First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui Province, 230031, People’s Republic of China; 2Center for Xin’an Medicine and Modernization of ...
Zhao JD, Fang ZH
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Herbal Diet and the Impact of Nutrition on Lipogenic Activity, a System Biology Study [PDF]
Research Journal of Pharmacognosy, 2023 Background and objectives: Human diet is branded with higher caloric and protein content and cooking processes in comparison with the diet of the primate species. The aim of this study was to explore the differences between human diet and chimpanzee diet
Mostafa Rezaei Tavirani +3 more
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Identification of FDFT1 as a potential biomarker associated with ferroptosis in ccRCC
Cancer Medicine, 2022 Renal cell carcinoma (RCC) seriously threatens people's lives and health. The identification of some precise biomarkers during the process of RCC progression and the pathophysiologic procedure is critical for improving the diagnosis and management of RCC.
Ruizhen Huang +8 more
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Gene Expression Profiles Modulated by Lipophilic Sea Buckthorn (<i>Hippophae rhamnoides</i> L.) Extract in BT-549 Triple-Negative Breast Cancer Cells. [PDF]
Food Sci NutrTranscriptomic profiling showed that carotenoid‐rich lipophilic sea buckthorn extract (LSBE) significantly altered genes controlling cholesterol metabolism, mTORC1 signaling, oxidative stress, and ferroptosis in BT‐549 TNBC cells. These findings generate mechanistic hypotheses for LSBE as a potential complementary approach in TNBC therapy, pending ...
Visan S +4 more
europepmc +2 more sources
Cholesterol mediated ferroptosis suppression reveals essential roles of Coenzyme Q and squalene
Communications Biology, 2023 Recent findings have shown that fatty acid metabolism is profoundly involved in ferroptosis. However, the role of cholesterol in this process remains incompletely understood.
Qi Sun +11 more
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Examining Farnesyltransferase Interaction With Cell-Permeable CaaX Peptides and the Role of the CaaX Motif in Biological Activity. [PDF]
J Pept SciThis work examines the interaction between farnesyltransferase (FTase) and cell‐permeable CaaX peptides. Particularly, peptide CaaX‐1 is presented as efficient binder to FTase capable to inhibit further interaction of other CaaX motif–bearing peptides. Moreover, biological effects require an intact CaaX motif.
Klußmann M +3 more
europepmc +2 more sources
Nature Communications, 2020 Evidence suggests that fasting exerts extensive antitumor effects in various cancers, including colorectal cancer (CRC). However, the mechanism behind this response is unclear.
Mei-lin Weng +15 more
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Cellular & Molecular Biology Letters, 2022 Bladder cancer is the fourth most common malignancy in males. It can present across the whole continuum of severity, from mild through well-differentiated disease to extremely malignant tumours with poor survival rates.
M. Kanmalar +7 more
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