Results 21 to 30 of about 2,830 (142)

Genomic alterations in primary gastric adenocarcinomas correlate with clinicopathological characteristics and survival. [PDF]

, 2004
Background & aimsPathogenesis of gastric cancer is driven by an accumulation of genetic changes that to a large extent occur at the chromosomal level. In order to investigate the patterns of chromosomal aberrations in gastric carcinomas, we performed
Albertson, Donna, Kuipers, Ernst J, Meijer, Gerrit A, Meuwissen, Stefan GM, Pinkel, Daniel, Postma, Cindy, Snijders, Antoine M, Weiss, Marjan M   +7 more
core   +3 more sources

Isoprenoid Biosynthesis in Plasmodium falciparum [PDF]

, 2014
Malaria kills nearly 1 million people each year, and the protozoan parasite Plasmodium falciparum has become increasingly resistant to current therapies.
Amthor, Rachel E, Guggisberg, Ann M, Odom, Audrey R   +2 more
core   +2 more sources

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18:Enzymes [PDF]

, 2017
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and ...
,, Alexander, Stephen Ph, Davies, Jamie A, Fabbro, Doriano, Faccenda, Elena, Harding, Simon D, Kelly, Eamonn, Marrion, Neil V, Pawson, Adam J, Peters, John A, Sharman, Joanna L, Southan, Christopher   +11 more
core   +15 more sources

Alteration of Mevalonate Pathway Related Enzyme Expressions in Pressure Overload-Induced Cardiac Hypertrophy and Associated Heart Failure with Preserved Ejection Fraction

Cellular Physiology and Biochemistry, 2013
Background: Abnormalities of the mevalonate pathway, an important cellular metabolic pathway, are common in many diseases including cardiovascular disease. The mevalonate pathway related enzyme expressions in pressure overload-induced cardiac hypertrophy
Bin Chen, Li-Yun Zhong, Jin-Xiu Yang, Yan-Yun Pan, Fei Chen, Jian Yang, Tao Wu, Shen-Jiang Hu   +7 more
doaj   +1 more source

Inhibiting mevalonate pathway enzymes increases stromal cell resilience to a cholesterol-dependent cytolysin [PDF]

, 2017
Animal health depends on the ability of immune cells to kill invading pathogens, and on the resilience of tissues to tolerate the presence of pathogens.
A Baxter, A Bellier, A Das, AE Christian, AF Read, B Page, BH Jost, BN Bonnett, CY Kao, DL Huffman, DO Ballard, DS Schneider, EP Kilsdonk, G Krikun, G Preta, GD Healey, IM Sheldon, IM Sheldon, JD Bergstrom, JG Cronin, JL Goldstein, JL Goldstein, JM Park, JW Rosch, K Bloch, KS Giddings, L Gurcel, L Pokrajac, L Raberg, LJ Bischof, LJ Sharpe, MD Peraro, MJ Rogers, ML Turner, MLS Bicalho, MR Amos, MR Gonzalez, R Medzhitov, RK Tweten, S Statt, S Westermann, SA Bustin, SJ Billington, SJ Billington, SJ Billington, T Mosmann, Y Lange   +46 more
core   +2 more sources

Cloning and characterisation of chlorophyll synthase from Avena sativa [PDF]

, 2001
The chlorophyll synthase gene from oat (Avena sativa) was cloned and expressed in Escherichia coli. The deduced amino acid sequence consists of 378 amino acids including a presequence, of 46 amino acids.
Kögel, Julia, Lenz, Stefan, Oster, Ulrike, Rüdiger, Wolfhart, Schmid, Heidi C.   +4 more
core   +1 more source

Persistent Neuroadaptations in the Expression of Genes Involved in Cholesterol Homeostasis Induced by Chronic, Voluntary Alcohol Intake in Rats

Frontiers in Molecular Neuroscience, 2018
Alcohol use disorder (AUD) is associated with persistent adaptations in the brain that are believed to participate in the long-lasting vulnerability to relapse after abstinence.
Josette Alsebaaly, Josette Alsebaaly, Emilie Dugast, Emilie Dugast, Laure Favot, Lydia Rabbaa Khabbaz, Marcello Solinas, Nathalie Thiriet   +7 more
doaj   +1 more source

Hepatitis C virus genotypes 1–3 infections regulate lipogenic signaling and suppress cholesterol biosynthesis in hepatocytes

Journal of the Formosan Medical Association, 2020
Background: Patients with different hepatitis C virus (HCV) genotype infections are associated with varying metabolic disorders. Although alteration of lipid metabolism has been confirmed as a virus-induced metabolic derangement in chronic hepatitis C ...
Ching-Sheng Hsu, Wei-Liang Liu, Qisheng Li, Brianna Lowey, Laura Hertz, You-Chen Chao, T. Jake Liang, Ding-Shinn Chen, Jia-Horng Kao   +8 more
doaj   +1 more source

Isoprenoid biosynthesis in the erythrocytic stages of Plasmodium falciparum [PDF]

, 2011
The development of new drugs is one strategy for malaria control. Biochemical pathways localised in the apicoplast of the parasite, such as the synthesis of isoprenic precursors, are excellent targets because they are different or absent in the human ...
JORDÃO, Fabiana Morandi, KATZIN, Alejandro Miguel, KIMURA, Emília Akemi   +2 more
core   +3 more sources

Weekly paclitaxel, gemcitabine, and external irradiation followed by randomized farnesyl transferase inhibitor R115777 for locally advanced pancreatic cancer. [PDF]

, 2012
PURPOSE: The Radiation Therapy Oncology Group (RTOG) multi-institutional Phase II study 98-12, evaluating paclitaxel and concurrent radiation (RT) for locally advanced pancreatic cancer, demonstrated a median survival of 11.3 months and a 1-year survival
Anne, Pramila R, Cline-Burkhardt, Vivian Jm, Erickson, Beth, Hoffman, John P, Myerson, Robert J, Perez, Kimberly, Rich, Tyvin A, Safran, Howard, Willett, Christopher, Winter, Kathryn   +9 more
core   +1 more source