Results 161 to 170 of about 9,308 (197)

Essential role for PfHSP40 in asexual replication and thermotolerance of malaria parasites. [PDF]

PLoS Pathog
Roper B, Kannan D, Mathews ES, Odom John AR.   +3 more
europepmc   +1 more source

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Farnesyl-Derived Inhibitors of ras Farnesyl Transferase

Biochemical and Biophysical Research Communications, 1995
The synthesis and evaluation of farnesyl-derived inhibitors of ras farnesyl transferase are presented. Evaluation of inhibitors of farnesyl transferase and comparison with the previously described inhibitor was accomplished using purified enzyme and Amersham's Farnesyl:Transferase enzyme assay kit.
M S, Kang, D M, Stemerick, J H, Zwolshen, B S, Harry, P S, Sunkara, B L, Harrison   +5 more
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Farnesyl Transferase Inhibitors

Cancer Investigation, 2007
Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.
Tianhong, Li, Joseph A, Sparano
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Farnesyl Diphosphate-Based Inhibitors of Ras Farnesyl Protein Transferase

Journal of Medicinal Chemistry, 1995
The rational design, synthesis, and biological activity of farnesyl diphosphate (FPP)-based inhibitors of the enzyme Ras farnesyl protein transferase (FPT) is described. Compound 3, wherein a beta-carboxylic phosphonic acid type pyrophosphate (PP) surrogate is connected to the hydrophobic farnesyl group by an amide linker, was found to be a potent (I50(
D V, Patel, R J, Schmidt, S A, Biller, E M, Gordon, S S, Robinson, V, Manne   +5 more
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Characterization of Farnesyl Diphosphate Farnesyl Transferase 1 ( FDFT1 ) Expression In Cancer

Personalized Medicine, 2018
To help characterize the FDFT1 gene and protein expression in cancer. Cholesterol represents an important structural component of lipid rafts. These specializations can be involved in pathways stimulating cell growth, survival and other processes active in cancer.
Tüzmen, Şükrü, Hostetter, Galen, Watanabe, Aprill, Ekmekçi, Cumhur, Carrigan, Patricia E., Shechter, Ishaiahu, Kallioniemi, Olli, Miller, Laurence J., Mousses, Spyro   +8 more
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Protein farnesylation and disease

Journal of Inherited Metabolic Disease, 2012
AbstractPrenylation consists of the addition of an isoprenoid group to a cysteine residue located near the carboxyl terminal of a protein. This enzymatic posttranslational modification is important for the maturation and processing of proteins. Both processes are necessary to mediate protein‐protein and membrane‐protein associations, in addition to ...
NOVELLI, GIUSEPPE, D'APICE, MARIA ROSARIA   +1 more
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Photoaffinity Analogues of Farnesyl Pyrophosphate Transferable by Protein Farnesyl Transferase

Journal of the American Chemical Society, 2002
Farnesylation is a posttranslational lipid modification in which a 15-carbon farnesyl isoprenoid is linked via a thioether bond to specific cysteine residues of proteins in a reaction catalyzed by protein farnesyltransferase (FTase). We synthesized analogues (3-6) of farnesyl pyrophosphate (FPP) to probe the range of modifications possible to the FPP ...
Kareem A H, Chehade, Katarzyna, Kiegiel, Richard J, Isaacs, Jennifer S, Pickett, Katherine E, Bowers, Carol A, Fierke, Douglas A, Andres, H Peter, Spielmann   +7 more
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Stereochemistry‐dependent inhibition of RAS farnesylation by farnesyl phosphonic acids

Lipids, 1998
AbstractThis investigation compares the effects of three farnesyl pyrophosphate analogs on selected aspects of isoprenoid metabolism. E,E‐α‐Hydroxyfarnesylphosphonate was prepared by an improved variation on a literature synthesis, which also gave access to the new Z,E‐α‐hydroxyfarnesyl‐ and α‐hydroxygeranylphosphonates.
R J, Hohl, K A, Lewis, D M, Cermak, D F, Wiemer   +3 more
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Expression cloning of farnesylated proteins

2001
Publisher Summary The identification of novel prenylated proteins has most often involved the labeling of cultured cells with [3H] mevalonolactone that is enzymatically converted to [3H] farnesyl pyrophosphate (FPP) and [3H] geranylgeranyl pyrophosphate (GGPP) prior to being incorporated into protein.
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Farnesylation

2014
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