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Novel Fas-TNFR chimeras that prevent Fas ligand-mediated kill and signal synergistically to enhance CAR T cell efficacy [PDF]
Molecular Therapy: Nucleic Acids, 2023 The hostile tumor microenvironment limits the efficacy of adoptive cell therapies. Activation of the Fas death receptor initiates apoptosis and disrupting these receptors could be key to increasing CAR T cell efficacy.
Callum McKenzie +9 more
doaj +2 more sources
Fas induces apoptosis in human coronary artery endothelial cells in vitro [PDF]
BMC Cell Biology, 2004 Background Published work suggests that some types of endothelial cells undergo apoptosis in response to ligation of the receptor Fas (CD95, APO1) but other types are resistant.
Wang Rongqi +5 more
doaj +3 more sources
Associations of serum soluble Fas and Fas ligand (FasL) with outcomes in systemic lupus erythematosus [PDF]
Lupus Science and Medicine, 2020 Objective Fas/Fas ligand (FasL) and B cell-activating factor (BAFF) signalling have pivotal roles in SLE pathogenesis. We investigated the clinical associations of serum concentrations of soluble Fas (sFas) and soluble FasL (sFasL) in SLE and their ...
Fabien B Vincent +6 more
doaj +2 more sources
Cisplatin-induced oxidative stress stimulates renal Fas ligand shedding [PDF]
Renal Failure, 2018 Acute kidney injury (AKI), a significant complication of cisplatin chemotherapy is associated with reactive oxygen species (ROS)-dependent renal cell death, but the cellular targets of ROS in cisplatin nephrotoxicity are not fully resolved.
Hitesh Soni +3 more
doaj +2 more sources
CD95/Fas ligand mRNA is toxic to cells [PDF]
eLife, 2018 CD95/Fas ligand binds to the death receptor CD95 to induce apoptosis in sensitive cells. We previously reported that CD95L mRNA is enriched in sequences that, when converted to si/shRNAs, kill all cancer cells by targeting critical survival genes ...
Will Putzbach +8 more
doaj +2 more sources
Indian Journal of Dermatology, 2018 Background: Alopecia areata (AA) is a common dermatologic disease with suspected autoimmune etiology. Tumor necrosis factor superfamily member 6 or CD95 (FAS) and FAS ligand (FASL) are proapoptotic proteins.
Iman Seleit +3 more
doaj +2 more sources
Tumor necrosis factor-alpha and Fas/Fas ligand signaling pathways in chronic spontaneous urticaria [PDF]
Allergy, Asthma & Clinical Immunology, 2019 Background There is increasing evidence pointing to the important role of tumor necrosis factor-alpha (TNF-α), a key inflammatory and apoptotic mediator in urticarial inflammation.
R. Grzanka +2 more
doaj +2 more sources
The Turkish Journal of Ear Nose and Throat, 2022 Objective: Larynx cancer constitutes 2% of all cancers in adults with 96% of larynx malignancies being squamous cell carcinoma (SHC). Apoptosis is a cell death mechanism that is quite different from necrosis.
Ahmet Mert Bilgili, Tolga Ersözlü
doaj +1 more source
Role of Apoptotic Biomarkers in Ameloblastoma and Dental Follicle
Journal of Dental School, 2021 Objectives Ameloblastoma is an odontogenic neoplasm with locally aggressive behavior. Fas and FasL play important roles in apoptotic pathways. The aim of this study was to determine the possible role of expression of apoptotic pathways (Fas and FasL) in
Fatemeh Mashhadiabbas +2 more
doaj +1 more source
Posttranslational regulation of Fas ligand function
Cell Communication and Signaling, 2008 The TNF superfamily member Fas ligand acts as a prototypic death factor. Due to its ability to induce apoptosis in Fas (APO-1, CD95) expressing cells, Fas ligand participates in essential effector functions of the immune system. It is involved in natural
Paulsen Maren +3 more
doaj +1 more source