Novel Fas-TNFR chimeras that prevent Fas ligand-mediated kill and signal synergistically to enhance CAR T cell efficacy [PDF]
Molecular Therapy: Nucleic Acids, 2023 The hostile tumor microenvironment limits the efficacy of adoptive cell therapies. Activation of the Fas death receptor initiates apoptosis and disrupting these receptors could be key to increasing CAR T cell efficacy.
Callum McKenzie +9 more
doaj +2 more sources
CD95/Fas ligand induced toxicity. [PDF]
Biochem Soc Trans, 2023 The role of CD95/Fas ligand (CD95L/FasL) in the induction of CD95-mediated extrinsic apoptosis is well characterized. Trimerized, membrane-bound CD95L ligates the CD95 receptor activating downstream signaling resulting in the execution of cells by caspase proteins.
Haluck-Kangas A, Peter ME.
europepmc +3 more sources
Associations of serum soluble Fas and Fas ligand (FasL) with outcomes in systemic lupus erythematosus [PDF]
Lupus Science and Medicine, 2020 Objective Fas/Fas ligand (FasL) and B cell-activating factor (BAFF) signalling have pivotal roles in SLE pathogenesis. We investigated the clinical associations of serum concentrations of soluble Fas (sFas) and soluble FasL (sFasL) in SLE and their ...
Fabien B Vincent +6 more
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Impairment of Fas-ligand-caveolin-1 interaction inhibits Fas-ligand translocation to rafts and Fas-ligand-induced cell death. [PDF]
Cell Death Dis, 2018 AbstractFas-ligand/CD178 belongs to the TNF family proteins and can induce apoptosis through death receptor Fas/CD95. The important requirement for Fas-ligand-dependent cell death induction is its localization to rafts, cholesterol- and sphingolipid-enriched micro-domains of membrane, involved in regulation of different signaling complexes.
Glukhova XA +4 more
europepmc +4 more sources
Cisplatin-induced oxidative stress stimulates renal Fas ligand shedding [PDF]
Renal Failure, 2018 Acute kidney injury (AKI), a significant complication of cisplatin chemotherapy is associated with reactive oxygen species (ROS)-dependent renal cell death, but the cellular targets of ROS in cisplatin nephrotoxicity are not fully resolved.
Hitesh Soni +3 more
doaj +2 more sources
CD95/Fas ligand mRNA is toxic to cells [PDF]
eLife, 2018 CD95/Fas ligand binds to the death receptor CD95 to induce apoptosis in sensitive cells. We previously reported that CD95L mRNA is enriched in sequences that, when converted to si/shRNAs, kill all cancer cells by targeting critical survival genes ...
Will Putzbach +8 more
doaj +2 more sources
Engineering adoptive T cell therapy to co-opt Fas ligand-mediated death signaling in ovarian cancer enhances therapeutic efficacy. [PDF]
J Immunother Cancer, 2022 Anderson KG +6 more
europepmc +3 more sources
Indian Journal of Dermatology, 2018 Background: Alopecia areata (AA) is a common dermatologic disease with suspected autoimmune etiology. Tumor necrosis factor superfamily member 6 or CD95 (FAS) and FAS ligand (FASL) are proapoptotic proteins.
Iman Seleit +3 more
doaj +2 more sources
Tumor necrosis factor-alpha and Fas/Fas ligand signaling pathways in chronic spontaneous urticaria [PDF]
Allergy, Asthma & Clinical Immunology, 2019 Background There is increasing evidence pointing to the important role of tumor necrosis factor-alpha (TNF-α), a key inflammatory and apoptotic mediator in urticarial inflammation.
R. Grzanka +2 more
doaj +2 more sources
Secreted Fas Decoys Enhance the Antitumor Activity of Engineered and Bystander T Cells in Fas Ligand-Expressing Solid Tumors. [PDF]
Cancer Immunol Res, 2022 Bajgain P +7 more
europepmc +3 more sources