Results 181 to 190 of about 106,589 (211)

Sensitization of immunoresistant prostate carcinoma cell lines to Fas/Fas ligand-mediated killing by cytotoxic lymphocytes: Independence of de novo protein synthesis

The Prostate, 1999
We recently reported that drug-resistant prostate tumor cells (DU145, PC-3) are resistant to Fas-mediated killing by cytotoxic lymphocytes, and that this resistance can be overcome by treatment with subtoxic concentrations of chemotherapeutic drugs. Fas belongs to the tumor necrosis factor (TNF) family of receptors.
P J, Frost, A, Belldegrun, B, Bonavida
openaire   +2 more sources

Effects of melittin on expressions of mitochondria membrane protein 7A6, cell apoptosis-related gene products Fas and Fas Ligand in hepatocarcinoma cells

Journal of Chinese Integrative Medicine, 2007
To observe the effects of melittin on the expressions of mitochondria membrane protein 7A6, cell apoptosis-related gene products Fas and Fas ligand (FasL) in hepatocarcinoma cells in vitro and to study the mechanisms of melittin in inducing apoptosis of hepatocarcinoma cells.BEL-7402 cell line was treated with melittin in vitro.
Chen, Zhang, Bai, Li, Shu-qin, Lu, Yong, Li, Yong-hua, Su, Chang-quan, Ling   +5 more
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Protein kinase C ζ  associates with death inducing signaling complex and regulates Fas ligand-induced apoptosis

Cellular Signalling, 2005
Previous studies have shown that Protein kinase C (PKC) stimulation may interfere with Fas signaling pathway and Fas ligand (FasL)-induced apoptosis. In this study, we investigated in Jurkat cells, a FasL-sensitive human T-cell model, whether PKC(zeta) targets apical events of Fas signaling. We describe for the first time that in Jurkat cells, both PKC(
Leroy, I, Dethonel, A, Laurent, G, Quilletmary, A   +3 more
openaire   +2 more sources

Fas ligand-induced apoptosis is regulated by nitric oxide through the inhibition of fas receptor clustering and the nitrosylation of protein kinase Cε

Experimental Cell Research, 2007
Apoptosis induced by the death-inducing ligand FasL (CD95L) is a major mechanism of cell death. Trophoblast cells express the Fas receptor yet survive in an environment that is rich in the ligand. We report that basal nitric oxide (NO) production is responsible for the resistance of trophoblasts to FasL-induced apoptosis.
Philip R, Dash, James, McCormick, Mika J C B, Thomson, Alan P, Johnstone, Judith E, Cartwright, Guy Stj, Whitley   +5 more
openaire   +2 more sources

Engineering of Bone Marrow Cells With Fas-ligand Protein–Enhances Donor-specific Tolerance to Solid Organs

Transplantation Proceedings, 2011
Effective immunomodulation to induce tolerance to tissue/organ allografts is attained by infusion of donor lymphocytes endowed with killing capacity through ectopic expression of a short-lived Fas-ligand (FasL) protein. The same approach has proven effective in improving hematopoietic stem and progenitor cell engraftment.
E M, Askenasy, Y, Shushlav, Z, Sun, H, Shirwan, E S, Yolcu, N, Askenasy   +5 more
openaire   +2 more sources

Fas and Fas ligand messenger ribonucleic acid and protein expression in the rat corpus luteum during apoptosis-mediated luteolysis.

Biology of reproduction, 1999
Apoptosis has been found to occur during regression of the corpus luteum (CL) in many species. The Fas (APO-1/CD95) receptor, a transmembrane protein that induces apoptosis in the cell when bound to Fas ligand (FasL), may be involved. This study established and quantitated the presence and regulation of Fas receptor and FasL in the rat CL during ...
Roughton, S.A., Lareu, R.R., Bittles, A.H., Dharmarajan, A.M.   +3 more
openaire   +1 more source

[Evaluation of restenosis by serum levels of soluble Fas, Fas ligand and nuclear matrix protein before and after coronary intervention].

Journal of cardiology, 2000
Serum levels of soluble Fas, soluble Fas ligand, and nuclear matrix protein (NMP) were measured in 38 patients with ischemic heart disease before and after coronary angiography or coronary intervention. Serum levels of soluble Fas, soluble Fas ligand and NMP were determined by enzyme-linked immunosorbent assay.
H, Hara, R, Sato, T, Katagiri, M, Hasegawa   +3 more
openaire   +1 more source

Current treatment and recent progress in gastric cancer

Ca-A Cancer Journal for Clinicians, 2021
Smita S Joshi, Brian D Badgwell
exaly  

Carbohydrate Structural Characterization of Fas Ligand Inhibitory Protein

2005
Lihua, Huang, Charles E, Mitchell, Lei, Yu, P, Clayton Gough, Alice, Riggin   +4 more
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Localization and Trafficking of the Death-Inducing Fas Ligand Protein in Cytotoxic T Lymphocytes

2014
Cytotoxic T lymphocytes (CTL) can kill tumor cells and cells infected with intracellular pathogens. Their two major killing mechanisms are the degranulation pathway and the Fas-FasL pathway. The degranulation process consists of the release of cytolytic perforin and granzyme molecules that are stored within lysosomal granules.
openaire   +1 more source