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Apoptosis signaling and cancer targeted therapy: from bench to bespoke. [PDF]

open access: yesTransl Cancer Res
Huang X   +5 more
europepmc   +1 more source
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The adaptor protein Grb2 regulates cell surface Fas ligand in Schwann cells

Biochemical and Biophysical Research Communications, 2008
Fas Ligand (FasL, CD178) is a cytokine that may be secreted or expressed as a transmembrane ligand at the cell surface, and induces apoptosis by binding to the "death receptor" Fas (CD95). Here, we show that Grb2, an SH3 domain-containing adaptor protein, binds to the proline-rich domain of FasL and regulates its cell surface expression.
William L Stanford, Julie Desbarats
exaly   +3 more sources

Altered protein expression levels of Fas/CD95 and Fas Ligand in differentially vulnerable brain areas in rats after global cerebral ischemia

Neuroscience Letters, 2003
To assess the role of the apoptosis-inducing death receptor Fas/CD95 and Fas Ligand (FasL) after global cerebral ischemia, expression of these proteins was investigated in differentially, i.e. selectively vulnerable brain areas. Following experimentally induced cardiac arrest of 6 min duration, rats were resuscitated.
S A Padosch, E Popp, B W Böttiger
exaly   +3 more sources

A novel Fas ligand in mollusk abalone: Molecular characterization, immune responses and biological activity of the recombinant protein

Fish and Shellfish Immunology, 2009
Fas ligand is a member of the TNF superfamily that plays an important role by inducing apoptosis and homeostasis of immune responses. The gene encoding Fas ligand was isolated from a disk abalone (Haliotis discus discus) cDNA library, denoted as the AbFas ligand. It contains an 1832bp transcript with a 945bp open reading frame, encoding 315 amino acids.
Chamilani Nikapitiya   +2 more
exaly   +3 more sources

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