Fas and Fas ligand protein and mRNA in normal and atretic mouse ovarian follicles [PDF]
Reproduction, 2003 Apoptosis is the underlying mechanism of follicular atresia in the mammalian ovary. However, the apoptotic pathways governing this ovarian process are not completely elucidated. In the present study, expression of Fas and Fas ligand, the proximal members of the death receptor pathway, was evaluated in mouse ovarian follicles using immunofluorescence ...
SJ Dharma, RL Kelkar, TD Nandedkar
semanticscholar +6 more sources
Expression of Fas and Fas ligand protein and mRNA in mouse oocytes and embryos [PDF]
Reproduction, 2003 During mammalian embryonic development, abnormal eggs and embryos are eliminated by apoptosis; however, the precise apoptotic pathways remain as yet unidentified. In the present study, expression of Fas and Fas ligand - the proximal members of the death receptor pathway, was evaluated in mouse preimplantation embryos by immunofluorescence and in situ ...
RL Kelkar, SJ Dharma, TD Nandedkar
semanticscholar +6 more sources
Carbon Monoxide Modulates Fas/Fas Ligand, Caspases, and Bcl-2 Family Proteins via the p38α Mitogen-activated Protein Kinase Pathway during Ischemia-Reperfusion Lung Injury [PDF]
Journal of Biological Chemistry, 2003 Carbon monoxide is protective in ischemia-reperfusion organ injury, but the precise mechanisms remain elusive. We have recently shown that low levels of exogenous carbon monoxide (CO) utilize p38 MAPK and attenuate caspase 3 activity to exert an ...
Xuchen Zhang +5 more
semanticscholar +5 more sources
IL-18-Binding Protein Protects Against Lipopolysaccharide- Induced Lethality and Prevents the Development of Fas/Fas Ligand-Mediated Models of Liver Disease in Mice [PDF]
The Journal of Immunology, 2001 AbstractIL-18-binding protein (IL-18BP) is a natural IL-18 inhibitor. Human IL-18BP isoform a was produced as fusion construct with human IgG1 Fc and assessed for binding and neutralizing IL-18. IL-18BP-Fc binds human, mouse, and rat IL-18 with high affinity (KD 0.3–5 nM) in a BIAcore-based assay.
Raffaella Faggioni +18 more
semanticscholar +5 more sources
Cell Detachment Triggers p38 Mitogen-activated Protein Kinase-dependent Overexpression of Fas Ligand [PDF]
Journal of Biological Chemistry, 2002 Kirill V. Rosen +3 more
semanticscholar +4 more sources
Systemic autoimmunity and defective Fas ligand secretion in the absence of the Wiskott-Aldrich syndrome protein [PDF]
Blood, 2010 AbstractAutoimmunity is a surprisingly common complication of primary immunodeficiencies, yet the molecular mechanisms underlying this clinical observation are not well understood. One widely known example is provided by Wiskott-Aldrich syndrome (WAS), an X-linked primary immunodeficiency disorder caused by mutations in the gene encoding the WAS ...
Nikolay P. Nikolov +8 more
semanticscholar +5 more sources
Role of P38 Mitogen-Activated Protein Kinase Phosphorylation and Fas-Fas Ligand Interaction in Morphine-Induced Macrophage Apoptosis [PDF]
The Journal of Immunology, 2002 AbstractIn this study, we evaluated the molecular mechanisms involved in morphine-induced macrophage apoptosis. Both morphine and TGF-β promoted P38 mitogen-activated protein kinase (MAPK) phosphorylation, and this phosphorylation was inhibited by SB 202190 as well as by SB 203580.
Pravin C. Singhal +8 more
semanticscholar +5 more sources
Fas-associated Death Domain Protein (FADD) and Caspase-8 Mediate Up-regulation of c-Fos by Fas Ligand and Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) via a FLICE Inhibitory Protein (FLIP)-regulated Pathway [PDF]
Journal of Biological Chemistry, 2001 Fas, a death domain-containing member of the tumor necrosis factor receptor family and its ligand FasL have been predominantly studied with respect to their capability to induce cell death.
Daniela Siegmund +9 more
semanticscholar +5 more sources
Endocrine Journal, 2003 There are two local subtypes of extravillous trophoblast (EVT): one is the proliferative phenotype of EVT, which primarily consists of proximal cells and the other is the invasive phenotype of EVT, which is composed mainly of distal cells of cell columns. The mechanism of invasion of EVT to the decidua remains obscure.
Homare Murakoshi +4 more
semanticscholar +5 more sources
Display of Fas Ligand Protein on Cardiac Vasculature as a Novel Means of Regulating Allograft Rejection [PDF]
Circulation, 2003 Background— Fas ligand (FasL) is a potent death-inducing molecule with important functions in immune homeostasis and tolerance to self-antigens. The complex biological activities of FasL and its inefficient expression using conventional gene transfer approaches limit its use for immunomodulation to ...
Nadir Askenasy +3 more
semanticscholar +4 more sources