Results 41 to 50 of about 287,562 (282)

Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening

BMC Immunology, 2009
Background - Fas ligand is a cytotoxic effector molecule of T and NK cells which is characterized by an intracellular N-terminal polyproline region that serves as a docking site for SH3 and WW domain proteins.
Lettau Marcus, Voss Matthias, Janssen Ottmar   +2 more
doaj   +1 more source

Serum soluble Fas ligand is a severity and mortality prognostic marker for COVID-19 patients

Frontiers in Immunology, 2022
Finding cytokine storm initiator factors associated with uncontrolled inflammatory immune response is necessary in COVID-19 patients. The aim was the identification of Fas/Fas Ligand (FasL) role in lung involvement and mortality of COVID-19 patients.
Kiarash Saleki, Kiarash Saleki, Kiarash Saleki, Kiarash Saleki, Moein Shirzad, Moein Shirzad, Moein Shirzad, Mostafa Javanian, Sheyda Mohammadkhani, Mohammad Hossein Alijani, Niloufarsadat Miri, Morteza Oladnabi, Abbas Azadmehr, Abbas Azadmehr, Abbas Azadmehr   +14 more
doaj   +1 more source

Effect of adjuvant therapy with ginkgo-damole on apoptosis, nerve injury and platelet aggregation of patients with acute cerebral infarction

Journal of Acute Disease, 2017
Objective: To investigate the effect of adjuvant therapy with ginkgo-damole on apoptosis, nerve injury and platelet aggregation of patients with acute cerebral infarction.
Zhi-Yong Lu
doaj   +1 more source

Receptor interacting protein-2 plays a critical role in human lung epithelial cells survival in response to Fas-induced cell-death. [PDF]

PLoS ONE, 2014
Lung epithelial cell death is critical to the lung injury that occurs in the acute respiratory distress syndrome. It is known that FasL plays a prominent role in this lung cell death pathway and may work in part through activation of the receptor ...
Mohd Akhlakur Rahman, Kruthika Sundaram, Srabani Mitra, Mikhail A Gavrilin, Mark D Wewers   +4 more
doaj   +1 more source

Fas induces apoptosis in human coronary artery endothelial cells in vitro

BMC Cell Biology, 2004
Background Published work suggests that some types of endothelial cells undergo apoptosis in response to ligation of the receptor Fas (CD95, APO1) but other types are resistant.
Wang Rongqi, Dincer Erhan, Gidea Claudia, Ang Edmund, Filippatos Gerasimos, Uhal Bruce D   +5 more
doaj   +1 more source

Deregulation of Fas ligand expression as a novel cause of autoimmune lymphoproliferative syndrome-like disease

Haematologica, 2015
Autoimmune lymphoproliferative syndrome is frequently caused by mutations in genes involved in the Fas death receptor pathway, but for 20–30% of patients the genetic defect is unknown.
Schafiq Nabhani, Sebastian Ginzel, Hagit Miskin, Shoshana Revel-Vilk, Dan Harlev, Bernhard Fleckenstein, Andrea Hönscheid, Prasad T. Oommen, Michaela Kuhlen, Ralf Thiele, Hans-Jürgen Laws, Arndt Borkhardt, Polina Stepensky, Ute Fischer   +13 more
doaj   +1 more source

Identification of the Calmodulin-Binding Domains of Fas Death Receptor. [PDF]

PLoS ONE, 2016
The extrinsic apoptotic pathway is initiated by binding of a Fas ligand to the ectodomain of the surface death receptor Fas protein. Subsequently, the intracellular death domain of Fas (FasDD) and that of the Fas-associated protein (FADD) interact to ...
Bliss J Chang, Alexandra B Samal, Jiri Vlach, Timothy F Fernandez, Dewey Brooke, Peter E Prevelige, Jamil S Saad   +6 more
doaj   +1 more source

Dominant inhibition of Fas ligand-mediated apoptosis due to a heterozygous mutation associated with autoimmune lymphoproliferative syndrome (ALPS) Type Ib

BMC Medical Genetics, 2007
Background: Autoimmune lymphoproliferative syndrome (ALPS) is a disorder of lymphocyte homeostasis and immunological tolerance due primarily to genetic defects in Fas (CD95/APO-1; TNFRSF6), a cell surface receptor that regulates apoptosis and its ...
McDonald Jay M, Reddy Vishnu, Makris Christopher, Dale Janet K, Zheng Lixin, Atkinson T Prescott, Pan George, Bi Lilia L, Siegel Richard M, Puck Jennifer M, Lenardo Michael J, Straus Stephen E   +11 more
doaj   +1 more source

Type-I interferon is critical for FasL expression on lung cells to determine the severity of influenza. [PDF]

PLoS ONE, 2013
Infection of influenza A virus in mammals induces hyper lung pneumonia, which often causes lethal diseases. FasL is a specific ligand of Fas, which is a type-I transmembrane protein to induce cell death.
Daisuke Fujikura, Satoko Chiba, Daisuke Muramatsu, Mika Kazumata, Yosuke Nakayama, Taro Kawai, Shizuo Akira, Hiroshi Kida, Tadaaki Miyazaki   +8 more
doaj   +1 more source

Transcriptional Regulation of Neuronal Genes and Its Effect on Neural Functions: Expression and Function of Forkhead Transcription Factors in Neurons

Journal of Pharmacological Sciences, 2005
Forkhead box transcription factor, class O (FOXO) is a mammalian homologue of DAF-16, which is known to regulate the lifespan of Caenorhabditis elegans and includes subfamilies of forkhead transcription factors such as AFX, FKHRL1, and FKHR.
Kohji Fukunaga, Takao Ishigami, Takayuki Kawano   +2 more
doaj   +1 more source