Alteration of Regulation of Fas/FasL Mediated Apoptosis in Gastric Cancer [PDF]
Revista Ciencias de la Salud, 2009 Gastric cancer is an important neoplasticdisease in all around the world because its highincidence and mortality. Otherwise, apoptosis isa key process of programmed cell death duringembryogenesis, regulation of immune system,and holding the tissue ...
Reggie García Robles +2 more
doaj
BMC Biotechnology, 2017 Background Fas ligand plays a key role in the human immune system as a major cell death inducing protein. The extracellular domain of human Fas ligand (hFasLECD) triggers apoptosis of malignant cells, and therefore is expected to have substantial ...
Michiro Muraki, Kiyonori Hirota
doaj +1 more source
Inhibition of death receptor signals by cellular FLIP. [PDF]
, 1997 The widely expressed protein Fas is a member of the tumour necrosis factor receptor family which can trigger apoptosis. However, Fas surface expression does not necessarily render cells susceptible to Fas ligand-induced death signals, indicating that ...
Bodmer, J.L. +12 more
core +1 more source
Fas activates lipolysis in a Ca2+-CaMKII-dependent manner in 3T3-L1 adipocytes[S]
Journal of Lipid Research, 2013 Fas (CD95) is a member of the tumor necrosis factor (TNF) receptor superfamily and plays a crucial role in the induction of apoptosis. However, like TNF, Fas can induce nonapoptotic signaling pathways.
Reto A. Rapold +4 more
doaj +1 more source
FLASH knockdown sensitizes cells to Fas-mediated apoptosis via down-regulation of the anti-apoptotic proteins, MCL-1 and Cflip short. [PDF]
PLoS ONE, 2012 FLASH (FLICE-associated huge protein or CASP8AP2) is a large multifunctional protein that is involved in many cellular processes associated with cell death and survival.
Song Chen +2 more
doaj +1 more source
Interactions of Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand (TRAIL) with the Immune System: Implications for Inflammation and Cancer [PDF]
, 2019 Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily. TRAIL has historically been distinct from the Fas ligand and TNFα in terms of selective apoptosis induction in tumor cells and has a nearly non ...
Baukloh, Ann-Kathrin +5 more
core +1 more source
Apoptosis and upregulation of TNF-α and TRAIL receptor 1 (DR4) in the pathogenesis of food protein-induced enterocolitis syndrome [PDF]
Korean Journal of Pediatrics, 2010 Purpose : Expression levels of tumor necrosis factor (TNF)-?#6181;xpression on the mucosa of the small intestine is increased in patients with villous atrophy in food protein-induced enterocolitis syndrome (FPIES).
Jin-Bok Hwang +5 more
doaj +1 more source
In vitro culture with gemcitabine augments death receptor and NKG2D ligand expression on tumour cells [PDF]
, 2019 Much effort has been made to try to understand the relationship between chemotherapeutic treatment of cancer and the immune system. Whereas much of that focus has been on the direct effect of chemotherapy drugs on immune cells and the release of antigens
A Ashkenazi +32 more
core +2 more sources
HIV Tat Binds Egr Proteins and Enhances Egr-dependent Transactivation of the Fas Ligand Promoter [PDF]
Journal of Biological Chemistry, 2002 HIV Tat can enhance activation-induced up-regulation of Fas ligand (FasL), which may contribute to T cell apoptosis in human immune deficiency virus (HIV)-infected individuals. We have assessed functional and physical interactions between Tat and the Egr family of transcription factors (Egr-1, -2, and -3), the latter two of which are major participants
Yili, Yang +4 more
openaire +2 more sources
Soluble Fas ligand drives autoantibody-induced arthritis by binding to DR5/TRAIL-R2
eLife, 2021 To date, no study has demonstrated that soluble Fas ligand (sFasL)-mediated inflammation is regulated via interaction with Fas in vivo. We found that FasL interacts specifically with tumor necrosis factor receptor superfamily (TNFRSF)10B, also known as ...
Dongjin Jeong +15 more
doaj +1 more source