Results 31 to 40 of about 184,173 (204)
iScience, 2021 Summary: VLGR1 (very large G protein-coupled receptor-1) is by far the largest adhesion G protein-coupled receptor in humans. Homozygous pathologic variants of VLGR1 cause hereditary deaf blindness in Usher syndrome 2C and haploinsufficiency of VLGR1 is ...
Deva K. Kusuluri +7 more
doaj +1 more source
Analysis of knockout/knockin mice that express a mutant FasL lacking the intracellular domain [PDF]
, 2009 Fas ligand (FasL; CD178; CD95L) is a type II transmembrane protein belonging to the tumour necrosis factor family; its binding to the Fas receptor (CD95; APO-1) triggers apoptosis in the receptor-bearing cell.
Kirkin, Vladimir +2 more
core +1 more source
Estrous cycle-dependent changes of Fas expression in the bovine corpus luteum: influence of keratin 8/18 intermediate filaments and cytokines [PDF]
, 2012 Background Fas expression and Fas-induced apoptosis are mechanisms attributed to the selective destruction of cells of the corpus luteum (CL) during luteal regression.
Birt, Alyssa +3 more
core +2 more sources
PLoS Biology, 2016 Demonstrations of both pro-apoptotic and pro-survival abilities of Fas (TNFRSF6/CD95/APO-1) have led to a shift from the exclusive "Fas apoptosis" to "Fas multisignals" paradigm and the acceptance that Fas-related therapies face a major challenge, as it ...
Krittalak Chakrabandhu +10 more
doaj +1 more source
Bistability in apoptosis by receptor clustering. [PDF]
PLoS Computational Biology, 2010 Apoptosis is a highly regulated cell death mechanism involved in many physiological processes. A key component of extrinsically activated apoptosis is the death receptor Fas which, on binding to its cognate ligand FasL, oligomerize to form the death ...
Kenneth L Ho, Heather A Harrington
doaj +1 more source
Swapping between Fas and Granulocyte Colony-stimulating Factor Receptor [PDF]
Journal of Biological Chemistry, 1996 Fas belongs to the tumor necrosis factor/nerve growth factor receptor family. The Fas ligand binds to its receptor, Fas, and induces apoptosis in Fas-bearing cells. The granulocyte colony-stimulating factor receptor (G-CSFR) is a member of the hemopoietic growth factor receptor family.
T, Takahashi +5 more
openaire +2 more sources
Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase. [PDF]
, 1994 Intracellular pathways leading from membrane receptor engagement to apoptotic cell death are still poorly characterized. We investigated the intracellular signaling generated after cross-linking of CD95 (Fas/Apo-1 antigen), a broadly expressed cell ...
Azuma, M +7 more
core +2 more sources
Journal for ImmunoTherapy of Cancer, 2022 Background In the USA, more than 50% of patients with ovarian cancer die within 5 years of diagnosis, highlighting the need for therapeutic innovations.
Philip D Greenberg +6 more
doaj +1 more source
Expression of Fas Receptor and Fas Ligand in Eczematous Dermatitis
Journal of Skin and Stem Cell, 2019 Background: The principal role of epidermal keratinocytes (KCs) in inducing and maintaining eczematous dermatitis has been rather neglected. Objectives: The study aimed to assess the expression of Fas receptor (FasR) and Fas ligand (FasL) in the skin of eczematous dermatitis patients to examine T-cell mediated KC apoptosis.
Hanan Rabea Nada +4 more
openaire +2 more sources
Life in the Fas lane: differential outcomes of Fas signalling [PDF]
, 2013 Fas, also known as CD95 or APO-1, is a member of the tumor necrosis factor/nerve growth factor superfamily. Although best characterized in terms of its apoptotic function, recent studies have identified several other cellular responses emanating from Fas.
Brint, Elizabeth K. +2 more
core +1 more source