Results 31 to 40 of about 97,027 (306)

Engagement of Fas on Macrophages Modulates Poly I:C induced cytokine production with specific enhancement of IP-10.

PLoS ONE, 2015
Viral double-stranded RNA (dsRNA) is recognised by pathogen recognition receptors such as Toll-Like Receptor 3 (TLR3) and retinoic acid inducible gene-I (RIG-I), and results in cytokine and interferon production. Fas, a well characterised death receptor,
Caitriona Lyons, Philana Fernandes, Liam J Fanning, Aileen Houston, Elizabeth Brint   +4 more
doaj   +1 more source

FAS-dependent cell death in α-synuclein transgenic oligodendrocyte models of multiple system atrophy. [PDF]

PLoS ONE, 2013
Multiple system atrophy is a parkinsonian neurodegenerative disorder. It is cytopathologically characterized by accumulation of the protein p25α in cell bodies of oligodendrocytes followed by accumulation of aggregated α-synuclein in so-called glial ...
Christine L Kragh, Gwenaëlle Fillon, Amanda Gysbers, Hanne D Hansen, Manuela Neumann, Christiane Richter-Landsberg, Christian Haass, Bernard Zalc, Catherine Lubetzki, Wei-Ping Gai, Glenda M Halliday, Philipp J Kahle, Poul H Jensen   +12 more
doaj   +1 more source

Tissue Inhibitor of Metalloproteinase-3 (TIMP-3) induces FAS dependent apoptosis in human vascular smooth muscle cells. [PDF]

PLoS ONE, 2018
Over expression of Tissue Inhibitor of Metalloproteinases-3 (TIMP-3) in vascular smooth muscle cells (VSMCs) induces apoptosis and reduces neointima formation occurring after saphenous vein interposition grafting or coronary stenting.
William R English, Heather Ireland-Zecchini, Andrew H Baker, Trevor D Littlewood, Martin R Bennett, Gillian Murphy   +5 more
doaj   +1 more source

An Evolution-Guided Analysis Reveals a Multi-Signaling Regulation of Fas by Tyrosine Phosphorylation and its Implication in Human Cancers.

PLoS Biology, 2016
Demonstrations of both pro-apoptotic and pro-survival abilities of Fas (TNFRSF6/CD95/APO-1) have led to a shift from the exclusive "Fas apoptosis" to "Fas multisignals" paradigm and the acceptance that Fas-related therapies face a major challenge, as it ...
Krittalak Chakrabandhu, Sébastien Huault, Jérôme Durivault, Kévin Lang, Ly Ta Ngoc, Angelique Bole, Eszter Doma, Benoit Dérijard, Jean-Pierre Gérard, Michel Pierres, Anne-Odile Hueber   +10 more
doaj   +1 more source

Bistability in apoptosis by receptor clustering. [PDF]

PLoS Computational Biology, 2010
Apoptosis is a highly regulated cell death mechanism involved in many physiological processes. A key component of extrinsically activated apoptosis is the death receptor Fas which, on binding to its cognate ligand FasL, oligomerize to form the death ...
Kenneth L Ho, Heather A Harrington
doaj   +1 more source

Engineering adoptive T cell therapy to co-opt Fas ligand-mediated death signaling in ovarian cancer enhances therapeutic efficacy

Journal for ImmunoTherapy of Cancer, 2022
Background In the USA, more than 50% of patients with ovarian cancer die within 5 years of diagnosis, highlighting the need for therapeutic innovations.
Philip D Greenberg, Kristin G Anderson, Shannon K Oda, Breanna M Bates, Madison G Burnett, Magdalia Rodgers Suarez, Susan L Ruskin   +6 more
doaj   +1 more source

Nutrient-dependent phosphorylation channels lipid synthesis to regulate PPARα

Journal of Lipid Research, 2013
Peroxisome proliferator-activated receptor (PPAR)α is a nuclear receptor that coordinates liver metabolism during fasting. Fatty acid synthase (FAS) is an enzyme that stores excess calories as fat during feeding, but it also activates hepatic PPARα by ...
Anne P.L. Jensen-Urstad, Haowei Song, Irfan J. Lodhi, Katsuhiko Funai, Li Yin, Trey Coleman, Clay F. Semenkovich   +6 more
doaj   +1 more source

Expression of Fas Receptor and Fas Ligand in Eczematous Dermatitis

Journal of Skin and Stem Cell, 2019
Background: The principal role of epidermal keratinocytes (KCs) in inducing and maintaining eczematous dermatitis has been rather neglected. Objectives: The study aimed to assess the expression of Fas receptor (FasR) and Fas ligand (FasL) in the skin of eczematous dermatitis patients to examine T-cell mediated KC apoptosis.
Hanan Rabea Nada, Ahmed M. Nada, Laila A. Rashed, Mira M. Abdel Halim, Maha Fathy Elmasry   +4 more
openaire   +2 more sources

Fas/CD95 prevents autoimmunity independently of lipid raft localization and efficient apoptosis induction

Nature Communications, 2016
Fas drives apoptosis and mutations in this receptor can cause autoimmunity through failure of cell death. Here, the authors uselpr/lprmice with palmitoylation-defective mutant Fas to provide evidence that Fas might limit spontaneous autoimmunity through ...
Anthony C. Cruz, Madhu Ramaswamy, Claudia Ouyang, Christopher A. Klebanoff, Prabuddha Sengupta, Tori N. Yamamoto, Françoise Meylan, Stacy K. Thomas, Nathan Richoz, Robert Eil, Susan Price, Rafael Casellas, V. Koneti Rao, Jennifer Lippincott-Schwartz, Nicholas P. Restifo, Richard M. Siegel   +15 more
doaj   +1 more source

An examination of the Apo-1/Fas promoter Mva I polymorphism in Japanese patients with multiple sclerosis

BMC Neurology, 2002
Background The Apo-1/Fas (CD95) molecule is an apoptosis-signaling cell surface receptor belonging to the tumor necrosis factor (TNF) receptor family. Both Fas and Fas ligand (FasL) are expressed in activated mature T cells, and prolonged cell activation
Yabe Ichiro, Miyagishi Ryuji, Fukazawa Toshiyuki, Kikuchi Seiji, Niino Masaaki, Tashiro Kunio   +5 more
doaj   +1 more source