Results 41 to 50 of about 184,173 (204)

Nutrient-dependent phosphorylation channels lipid synthesis to regulate PPARα

Journal of Lipid Research, 2013
Peroxisome proliferator-activated receptor (PPAR)α is a nuclear receptor that coordinates liver metabolism during fasting. Fatty acid synthase (FAS) is an enzyme that stores excess calories as fat during feeding, but it also activates hepatic PPARα by ...
Anne P.L. Jensen-Urstad, Haowei Song, Irfan J. Lodhi, Katsuhiko Funai, Li Yin, Trey Coleman, Clay F. Semenkovich   +6 more
doaj   +1 more source

Opioid receptor blockade reduces Fas-induced hepatitis in mice [PDF]

Hepatology, 2004
Fas (CD95)-induced hepatocyte apoptosis and cytotoxic activity of neutrophils infiltrating the injured liver are two major events leading to hepatitis. Because it has been reported that opioids, via a direct interaction, sensitize splenocytes to Fas-mediated apoptosis by upregulating Fas messenger RNA (mRNA) and modulated ...
Martial, Jaume, Sébastien, Jacquet, Pierre, Cavaillès, Gaëtane, Macé, Lionel, Stephan, Catherine, Blanpied, Cécile, Demur, Pierre, Brousset, Gilles, Dietrich   +8 more
openaire   +2 more sources

Fetal-derived trophoblast use the apoptotic cytokine tumor necrosis factor-alpha-related apoptosis-inducing ligand to induce smooth muscle cell death. [PDF]

, 2007
Remodeling of the uterine spiral arteries during pregnancy transforms them from high to low resistance vessels that lack vasoconstrictive properties. This process is essential to meet the demand for increased blood flow imposed by the growing fetus. Loss
Aplin, JD, Baker, PN, Cartwright, JE, Freeman, A, Harris, LK, Keogh, RJ, Whitley, GS   +6 more
core   +1 more source

Fas/CD95 prevents autoimmunity independently of lipid raft localization and efficient apoptosis induction

Nature Communications, 2016
Fas drives apoptosis and mutations in this receptor can cause autoimmunity through failure of cell death. Here, the authors uselpr/lprmice with palmitoylation-defective mutant Fas to provide evidence that Fas might limit spontaneous autoimmunity through ...
Anthony C. Cruz, Madhu Ramaswamy, Claudia Ouyang, Christopher A. Klebanoff, Prabuddha Sengupta, Tori N. Yamamoto, Françoise Meylan, Stacy K. Thomas, Nathan Richoz, Robert Eil, Susan Price, Rafael Casellas, V. Koneti Rao, Jennifer Lippincott-Schwartz, Nicholas P. Restifo, Richard M. Siegel   +15 more
doaj   +1 more source

An examination of the Apo-1/Fas promoter Mva I polymorphism in Japanese patients with multiple sclerosis

BMC Neurology, 2002
Background The Apo-1/Fas (CD95) molecule is an apoptosis-signaling cell surface receptor belonging to the tumor necrosis factor (TNF) receptor family. Both Fas and Fas ligand (FasL) are expressed in activated mature T cells, and prolonged cell activation
Yabe Ichiro, Miyagishi Ryuji, Fukazawa Toshiyuki, Kikuchi Seiji, Niino Masaaki, Tashiro Kunio   +5 more
doaj   +1 more source

Fas and Fas Ligand are associated with neuritic degeneration in the AD brain and participate in β-amyloid-induced neuronal death

Neurobiology of Disease, 2003
It has recently been suggested that neuronal cell death in response to many brain insults may be mediated by the upregulation of tumor necrosis factor receptor (TNFR) family members and their ligands.
Joseph H Su, Aileen J Anderson, David H Cribbs, Christina Tu, Liqi Tong, Patrick Kesslack, Carl W Cotman   +6 more
doaj   +1 more source

Characterization of Bone Structure in Leptin Receptor-Deficient Zucker (fa/fa) Rats

Journal of Bone and Mineral Research, 2003
Abstract To investigate the role of leptin in bone formation, the skeleton of the obese female leptin receptor-deficient Zucker rat was examined using pQCT, μCT, and histomorphometry. A trend toward decreasing structural and bone formation parameters in these rats as they age suggest that leptin has a small positive effect on bone.
Joseph A, Tamasi, Brian J, Arey, Donald R, Bertolini, Jean H M, Feyen   +3 more
openaire   +2 more sources

A mutation in caspase-9 decreases the expression of BAFFR and ICOS in patients with immunodeficiency and lymphoproliferation [PDF]

, 2015
Lymphocyte apoptosis is mainly induced by either death receptor-dependent activation of caspase-8 or mitochondria-dependent activation of caspase-9. Mutations in caspase-8 lead to autoimmunity/lymphoproliferation and immunodeficiency. This work describes
Boggio, E, Cappellano, G, Chiocchetti, A., Clemente, N, Dianzani, C, Dianzani, I, Dianzani, U, Gigliotti, Cl, Notarangelo, Ld, Orilieri, E, Pignata, C, Quinti, Isabella, Ramenghi, U, Santoro, C, Toth, E, Valletti, Pa   +15 more
core   +2 more sources

MOAP-1 Mediates Fas-Induced Apoptosis in Liver by Facilitating tBid Recruitment to Mitochondria

Cell Reports, 2016
Fas apoptotic signaling regulates diverse physiological processes. Acute activation of Fas signaling triggers massive apoptosis in liver. Upon Fas receptor stimulation, the BH3-only protein Bid is cleaved into the active form, tBid.
Chong Teik Tan, Qi-Ling Zhou, Yu-Chin Su, Nai Yang Fu, Hao-Chun Chang, Ran N. Tao, Sunil K. Sukumaran, Shairaz Baksh, Yee-Joo Tan, Kanaga Sabapathy, Chun-Dong Yu, Victor C. Yu   +11 more
doaj   +1 more source

Fas death receptor signalling: roles of Bid and XIAP [PDF]

Cell Death & Differentiation, 2011
Fas (also called CD95 or APO-1), a member of a subgroup of the tumour necrosis factor receptor superfamily that contain an intracellular death domain, can initiate apoptosis signalling and has a critical role in the regulation of the immune system. Fas-induced apoptosis requires recruitment and activation of the initiator caspase, caspase-8 (in humans ...
Kaufmann T, Strasser A, Jost P J
openaire   +3 more sources