Results 51 to 60 of about 797,546 (295)

Experimental and numerical investigation of the Doppler-shifted resonance condition for high frequency Alfvén eigenmodes on ASDEX Upgrade

Nuclear Fusion
The Doppler-shifted resonance condition for high frequency Alfvénic eigenmodes has been extensively studied on ASDEX Upgrade in the presence of one or a combination of two neutral beam injected (NBI) fast ion populations.
R. Ochoukov, R. Bilato, V. Bobkov, H. Faugel, A. Kappatou, P. Schneider, M. Weiland, M. Dreval, S. Sipilä, R. Dendy, T. Johnson, Ye Kazakov, K.G. McClements, D. Moseev, M. Salewski, ASDEX Upgrade Team, EUROfusion Tokamak Exploitation Team   +16 more
doaj   +1 more source

Fast separation of two trapped ions

New Journal of Physics, 2015
We design fast protocols to separate or recombine two ions in a segmented Paul trap. By inverse engineering the time evolution of the trapping potential composed of a harmonic and a quartic term, it is possible to perform these processes in a few ...
M Palmero, S Martínez-Garaot, U G Poschinger, A Ruschhaupt, J G Muga   +4 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Impact of fast ions on microturbulence and zonal flow dynamics in HL-2A internal transport barriers

Nuclear Fusion, 2023
The turbulent transport properties and dynamics of zonal flows (ZFs) in the presence of fast ions (FIs) are investigated for a typical internal transport barrier (ITB) plasma based on the gyrokinetic approach, focusing on the role of FI temperature and ...
J.Q. Xu, X.D. Peng, W. Chen, G.Z. Hao, J.Q. Li, H.P. Qu, Z.J. Li, X.X. He, Y.G. Li, M. Jiang, X. Yu, J. Wen, Z.C. Yang, the HL-2A Team   +13 more
doaj   +1 more source

Fast and efficient transport of large ion clouds

, 2015
The manipulation of trapped charged particles by electric fields is an accurate, robust and reliable technique for many applications or experiments in high-precision spectroscopy.
Champenois, Caroline, Guyomarc'H, Didier, Houssin, Marie, Kamsap, Marius Romuald, Knoop, Martina, Pedregosa-Gutierrez, Jofre   +5 more
core   +4 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Phase-space spectrum analysis of fast-ion resonances with externally applied 3D magnetic perturbations in the EAST tokamak

Nuclear Fusion
The spectral configurations of resonant magnetic perturbations (RMPs) play a key role in the transport and confinement of fast ions. In this paper, we aim to provide a quantitative investigation on how the RMP spectrum affects fast-ion resonances in the ...
K. He, Y. Sun, Y.Q. Liu, B.N. Wan
doaj   +1 more source

Visualization of phase-space orbit topological boundary using imaging neutral particle analyzer

Nuclear Fusion, 2023
A newly-developed Imaging Neutral Particle Analyzer (INPA) in the DIII-D tokamak interrogates phase space occupied by fast ions on multiple different orbit topologies, including passing, stagnation, trapped and potato orbits.
X.D. Du, J. Gonzalez-Martin, D. Liu, W.W. Heidbrink, M.A. Van Zeeland   +4 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Modeling of heat flux on the main limiter in EAST

Nuclear Fusion
Heat flux on plasma-facing components is one of the key issues in tokamak operation. In EAST, severe damages occurred on the main limiters due to high heat loads limit high-power and long-pulse operation in recent campaigns.
Binfu Gao, Dahuan Zhu, Rui Ding, Chuannan Xuan, Bin Zhang, Rong Yan, Mehdi Firdaouss, Shaocheng Liu, Yang Wang, Zongxiao Guo, Chunyu He, Wenxue Fu, Baoguo Wang, Junling Chen, the EAST team   +14 more
doaj   +1 more source