Results 61 to 70 of about 798,983 (300)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Phase-space spectrum analysis of fast-ion resonances with externally applied 3D magnetic perturbations in the EAST tokamak

Nuclear Fusion
The spectral configurations of resonant magnetic perturbations (RMPs) play a key role in the transport and confinement of fast ions. In this paper, we aim to provide a quantitative investigation on how the RMP spectrum affects fast-ion resonances in the ...
K. He, Y. Sun, Y.Q. Liu, B.N. Wan
doaj   +1 more source

Fast and efficient transport of large ion clouds

, 2015
The manipulation of trapped charged particles by electric fields is an accurate, robust and reliable technique for many applications or experiments in high-precision spectroscopy.
Champenois, Caroline, Guyomarc'H, Didier, Houssin, Marie, Kamsap, Marius Romuald, Knoop, Martina, Pedregosa-Gutierrez, Jofre   +5 more
core   +4 more sources

Radial Transport Characteristics of Fast Ions Due to Energetic-Particle Modes inside the Last Closed-Flux Surface in the Compact Helical System [PDF]

, 2008
The internal behavior of fast ions interacting with magnetohydrodynamic bursts excited by energetic ions has been experimentally investigated in the compact helical system.
Akihide Fujisawa, Akihiro Shimizu, Chihiro Suzuki, Haruhisa Nakano, Kazuo Toi, Keisuke Matsuoka, Kenichi Nagaoka, Masaki Osakabe, Mitsutaka Isobe, Shin Nishimura, Shoichi Okamura, Shunsuke Ohshima, Tsuyoshi Akiyama, Yasuo Yoshimura, Yasushi Todo, Yoshihiko Nagashima   +15 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Numerical assessment of the impact of the guiding-centre approximation on fast ion simulations in NSTX

Nuclear Fusion
Guiding-centre (GC) and full-orbit (FO) simulations of the beam-injected fast ion distribution and the corresponding neutron emissivity have been carried out for magnetohydrodynamics-quiescent National Spherical Torus eXperiment (NSTX) plasmas, using a ...
I. Dolby, M. Cecconello, J. Yang, M. Podestà, S. Kaye   +4 more
doaj   +1 more source

Impact of fast ions on microturbulence and zonal flow dynamics in HL-2A internal transport barriers

Nuclear Fusion, 2023
The turbulent transport properties and dynamics of zonal flows (ZFs) in the presence of fast ions (FIs) are investigated for a typical internal transport barrier (ITB) plasma based on the gyrokinetic approach, focusing on the role of FI temperature and ...
J.Q. Xu, X.D. Peng, W. Chen, G.Z. Hao, J.Q. Li, H.P. Qu, Z.J. Li, X.X. He, Y.G. Li, M. Jiang, X. Yu, J. Wen, Z.C. Yang, the HL-2A Team   +13 more
doaj   +1 more source

New method for highly accurate calculations of the photodetachment cross-sections of the negatively charged hydrogen ions

, 2015
New approach to highly accurate calculations of the photodetachment cross-sections of the negatively charged hydrogen ions is developed. This effective, fast and numerically stable method is based on the use of the Rayleigh's formula for the spherical ...
Frolov, Alexei M.
core   +1 more source

Design and initial operation of lost fast-ion probe based on thin Faraday films in CHS [PDF]

, 2006
The purpose of this work is to measure lost fast ions as an ion current so as to make quantitative argument on flux of fast-ion loss possible. We have designed and constructed a lost fast-ion probe based on combination of thin Faraday films and small ...
A. Shimizu, C. Suzuki, CHS Team, , D. S. Darrow, Darrow D. S., K. Goto, K. Matsuoka, K. Nagaoka, K. Toi, M. Isobe, M. Nishiura, Nishimura K., S. Nishimura, S. Okamura, T. Akiyama, Y. Yoshimura   +15 more
core   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source