Results 51 to 60 of about 184,167 (263)

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Experimental and numerical investigation of the Doppler-shifted resonance condition for high frequency Alfvén eigenmodes on ASDEX Upgrade

Nuclear Fusion
The Doppler-shifted resonance condition for high frequency Alfvénic eigenmodes has been extensively studied on ASDEX Upgrade in the presence of one or a combination of two neutral beam injected (NBI) fast ion populations.
R. Ochoukov, R. Bilato, V. Bobkov, H. Faugel, A. Kappatou, P. Schneider, M. Weiland, M. Dreval, S. Sipilä, R. Dendy, T. Johnson, Ye Kazakov, K.G. McClements, D. Moseev, M. Salewski, ASDEX Upgrade Team, EUROfusion Tokamak Exploitation Team   +16 more
doaj   +1 more source

The Influence of Fast Particles on Plasma Rotation in the TUMAN-3M Tokamak

Atoms, 2022
In most present-day tokamaks, the majority of the heating power comes from sources such as neutral-beam injection (NBI) and other types of auxiliary heating which allow for the transfer of energy to the plasma by a small population of externally ...
Alexander Yashin, Alexander Belokurov, Leonid Askinazi, Alexander Petrov, Anna Ponomarenko, the TUMAN-3M Team   +5 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Phase-space spectrum analysis of fast-ion resonances with externally applied 3D magnetic perturbations in the EAST tokamak

Nuclear Fusion
The spectral configurations of resonant magnetic perturbations (RMPs) play a key role in the transport and confinement of fast ions. In this paper, we aim to provide a quantitative investigation on how the RMP spectrum affects fast-ion resonances in the ...
K. He, Y. Sun, Y.Q. Liu, B.N. Wan
doaj   +1 more source

Simulation of the loss of passing fast ions induced by magnetic islands in EAST tokamak plasmas

AIP Advances, 2021
The loss of beam ions due to magnetic islands is investigated in a tokamak. The perturbed guiding-center drifts of passing particles including the effect of the finite orbit width are demonstrated.
Limin Yu, Erbing Xue, Debing Zhang, Shuyu Zheng, Xianmei Zhang, Juan Huang, Erzhong Li, Zheng-Mao Sheng, Jing Fu   +8 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Numerical assessment of the impact of the guiding-centre approximation on fast ion simulations in NSTX

Nuclear Fusion
Guiding-centre (GC) and full-orbit (FO) simulations of the beam-injected fast ion distribution and the corresponding neutron emissivity have been carried out for magnetohydrodynamics-quiescent National Spherical Torus eXperiment (NSTX) plasmas, using a ...
I. Dolby, M. Cecconello, J. Yang, M. Podestà, S. Kaye   +4 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source