Results 71 to 80 of about 798,983 (300)

Observation and interpretation of core ion cyclotron emission driven by D–D fusion-produced tritium ions in EAST

Nuclear Fusion
Recently, in a series of EAST discharges using deuterium neutral beam injection (NBI), tritium (T) ions were produced via deuterium–deuterium (D–D) fusion reactions, resulting in excited ion cyclotron emission (ICE) within the plasma core in H-mode ...
Huapeng Zhang, Lunan Liu, Wei Zhang, Xuan Sun, Xinjun Zhang, Zian Zhang, Yongxin Zhu, K. Ogawa, M. Isobe, Yifeng Zheng, Hui Liao, Chengming Qin, Guanghui Zhu, Yilin Li, Baoming Ren, Jingran Wen, Zixi Li   +16 more
doaj   +1 more source

Visualization of phase-space orbit topological boundary using imaging neutral particle analyzer

Nuclear Fusion, 2023
A newly-developed Imaging Neutral Particle Analyzer (INPA) in the DIII-D tokamak interrogates phase space occupied by fast ions on multiple different orbit topologies, including passing, stagnation, trapped and potato orbits.
X.D. Du, J. Gonzalez-Martin, D. Liu, W.W. Heidbrink, M.A. Van Zeeland   +4 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Overview of fast particle experiments in the first MAST Upgrade experimental campaigns

Nuclear Fusion
MAST-U is equipped with on-axis and off-axis neutral beam injectors (NBI), and these external sources of super-Alfvénic deuterium fast-ions provide opportunities for studying a wide range of phenomena relevant to the physics of alpha-particles in burning
J.F. Rivero-Rodríguez, K.G. McClements, M. Fitzgerald, S.E. Sharapov, M. Cecconello, N.A. Crocker, I. Dolby, M. Dreval, N. Fil, J. Galdón-Quiroga, M. García-Muñoz, S. Blackmore, W. Heidbrink, S. Henderson, A. Jackson, A. Kappatou, D. Keeling, D. Liu, Y.Q. Liu, C. Michael, H.J.C. Oliver, P. Ollus, E. Parr, G. Prechel, T. Rhodes, D. Ryan, P. Shi, M. Vallar, L. Velarde, T. Williams, H. Wong, the EUROfusion Tokamak Exploitation Team, the MAST-U Team   +32 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Study of ion cyclotron emission excited by tritium ions of fusion products via magnetoacoustic cyclotron instability theory in the EAST

Nuclear Fusion
This study investigates the ion cyclotron emission (ICE) excited by tritium ions generated through deuterium‒deuterium fusion reactions in the Experimental Advanced Superconducting Tokamak (EAST). ICE is an electromagnetic instability driven by fast ions,
Huapeng Zhang, Lunan Liu, Wei Zhang, Xuan Sun, Xinjun Zhang, Baolong Hao   +5 more
doaj   +1 more source

Diffuse 0.5-1 keV X-Rays and Nuclear Gamma-Rays from Fast Particles in the Local Hot Bubble

, 1998
We show that interactions of fast particles with the boundary shell of the local hot bubble could make an important contribution to the 0.5-1 keV diffuse X-ray background observed with ROSAT.
Gendreau K. C., Reuven Ramaty, Rocchia R., Vincent Tatischeff   +3 more
core   +3 more sources

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

FAST NEGATIVE HYDROGEN IONS

Canadian Journal of Physics, 1954
A proton beam was directed through hydrogen gas at low pressure and magnetic analysis of the emergent beam showed that an appreciable fraction of the beam was transformed into negative hydrogen ions. After the beam had traversed a sufficient layer of gas, the ratio of negative hydrogen ions to protons reached an equilibrium value which was a maximum ...
openaire   +2 more sources