Results 71 to 80 of about 184,167 (263)

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

Modeling of heat flux on the main limiter in EAST

Nuclear Fusion
Heat flux on plasma-facing components is one of the key issues in tokamak operation. In EAST, severe damages occurred on the main limiters due to high heat loads limit high-power and long-pulse operation in recent campaigns.
Binfu Gao, Dahuan Zhu, Rui Ding, Chuannan Xuan, Bin Zhang, Rong Yan, Mehdi Firdaouss, Shaocheng Liu, Yang Wang, Zongxiao Guo, Chunyu He, Wenxue Fu, Baoguo Wang, Junling Chen, the EAST team   +14 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Perturbative model for the saturation of energetic-particle-driven modes limited by self-generated zonal modes

Nuclear Fusion
We present a simplified energy-conserving approach to incorporate wave–wave nonlinear effects within the framework commonly used to describe wave–particle nonlinearities.
T. Barberis, V.N. Duarte, E.J. Hartigan-O’Connor, N.N. Gorelenkov   +3 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Diagnostic weight functions in constants-of-motion phase-space

Nuclear Fusion
The fast-ion phase-space distribution function in axisymmetric tokamak plasmas is completely described by the three constants of motion: energy, magnetic moment and toroidal canonical angular momentum. In this work, the observable regions of constants-of-
M. Rud, D. Moseev, F. Jaulmes, K. Bogar, J. Eriksson, H. Järleblad, M. Nocente, G. Prechel, B.C.G. Reman, B.S. Schmidt, A. Snicker, L. Stagner, A. Valentini, M. Salewski   +13 more
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Orbit tomography in constants-of-motion phase-space

Nuclear Fusion
Tomographic reconstructions of a 3D fast-ion constants-of-motion phase-space distribution function are computed by inverting synthetic signals based on projected velocities of the fast ions along the diagnostic lines of sight.
M. Rud, D. Moseev, F. Jaulmes, K. Bogar, Y. Dong, P.C. Hansen, J. Eriksson, H. Järleblad, M. Nocente, G. Prechel, B.C.G. Reman, B.S. Schmidt, A. Snicker, L. Stagner, A. Valentini, M. Salewski   +15 more
doaj   +1 more source