Results 81 to 90 of about 798,983 (300)

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Modeling of heat flux on the main limiter in EAST

Nuclear Fusion
Heat flux on plasma-facing components is one of the key issues in tokamak operation. In EAST, severe damages occurred on the main limiters due to high heat loads limit high-power and long-pulse operation in recent campaigns.
Binfu Gao, Dahuan Zhu, Rui Ding, Chuannan Xuan, Bin Zhang, Rong Yan, Mehdi Firdaouss, Shaocheng Liu, Yang Wang, Zongxiao Guo, Chunyu He, Wenxue Fu, Baoguo Wang, Junling Chen, the EAST team   +14 more
doaj   +1 more source

A scalable, high-speed measurement-based quantum computer using trapped ions

, 2009
We describe a scalable, high-speed, and robust architecture for measurement-based quantum-computing with trapped ions. Measurement-based architectures offer a way to speed-up operation of a quantum computer significantly by parallelizing the slow ...
A. G. Fowler, D. Hucul, Daniel F. V. James, J. Kim, M. A. Nielsen, René Stock   +5 more
core   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Perturbative model for the saturation of energetic-particle-driven modes limited by self-generated zonal modes

Nuclear Fusion
We present a simplified energy-conserving approach to incorporate wave–wave nonlinear effects within the framework commonly used to describe wave–particle nonlinearities.
T. Barberis, V.N. Duarte, E.J. Hartigan-O’Connor, N.N. Gorelenkov   +3 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Metal enrichment by radiation pressure in active galactic nucleus outflows -- theory and observations

, 2012
Outflows from active galactic nuclei may be produced by absorption of continuum radiation by UV resonance lines of abundant metal ions, as observed in broad absorption line quasars (BALQs).
Alexei Baskin, Allen, Arav, Arav, Arav, Arav, Arav, Arav, Arav, Ari Laor, Baskin, Becker, Brandt, Brandt, Chelouche, Chelouche, Chelouche, Cottis, Crenshaw, Cresci, de Kool, Di, Diamond-Stanic, Dietrich, Elvis, Everett, Fabian, Ferland, Ferland, Gallazzi, Gibson, Hamann, Hamann, Hamann, Hamann, Hamann, Hamann, Jannuzi, Jones, Junkkarinen, Knigge, Korista, Kulsrud, Kurosawa, Kwan, Königl, Lamers, Laor, Laor, Molina, Moll, Morton, Murray, Owocki, Proga, Proga, Proga, Proga, Proga, Reeves, Reichard, Rodríguez, Rodríguez Hidalgo, Rybicki, Scaringi, Schneider, Shakura, Shen, Spitzer, Springmann, Stocke, Telfer, Vitello, Wang, Weymann, Wu, York, Yuan, Zaritsky   +78 more
core   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Diagnostic weight functions in constants-of-motion phase-space

Nuclear Fusion
The fast-ion phase-space distribution function in axisymmetric tokamak plasmas is completely described by the three constants of motion: energy, magnetic moment and toroidal canonical angular momentum. In this work, the observable regions of constants-of-
M. Rud, D. Moseev, F. Jaulmes, K. Bogar, J. Eriksson, H. Järleblad, M. Nocente, G. Prechel, B.C.G. Reman, B.S. Schmidt, A. Snicker, L. Stagner, A. Valentini, M. Salewski   +13 more
doaj   +1 more source