Results 31 to 40 of about 1,046,396 (246)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Percepção da violência escolar para adolescentes da zona rurícola de Feira de Santana-BA

Revista Gestão & Saúde, 2016
A violência escolar é um fenômeno que cresce de forma vertiginosa causando impactos na sociedade e agravos à saúde. Assim, este estudo teve como objetivo, analisar a percepção da violência escolar para adolescentes da zona rurícola de Feira de Santana ...
Bianka Sousa Martins Silva, Sinara de Lima Souza, Maria Margarete Brito Martins, Émilin Nogueira Silva e Souza Freitas, Thaís Ramos Fraga   +4 more
doaj  

Monoacylglycerols as fruit juices preservatives

Czech Journal of Food Sciences, 2012
Limiting or preventing the growth of undesirable microbial flora in food products is one of the main goals of food microbiology. A number of preservation methods have been designed to extend the shelf-life of the food products by reducing the microbial ...
Iva DOLEŽÁLKOVÁ, Zdeněk MÁČALÍK, Adéla BUTKOVIČOVÁ, Rahula JANIŠ, Leona BUŇKOVÁ   +4 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Fat blends on the base of structural triglycerides

Czech Journal of Food Sciences, 2004
Fat blends for manufacture of trans isomer-free emulsified fats are prepared by blending of 20-30% of structured fat with vegetable oil. Structured fats on the base of trisaturated triglycerides are produced by basic or enzymatic catalyzed ...
V. Filip, M. Zárubová, I. Piska, J. Šmidrkal   +3 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Preparation of conjugated linoleic acid enriched derivatives by conventional and biphasic isomerisation

Czech Journal of Food Sciences, 2016
The preparation of conjugated linoleic acid (CLA)-enriched free fatty acids by industrial processes compared with our biphasic isomerisation experiments in a special designed reactor enabling the preparation of CLA esters was evaluated.
Jan Kyselka, Lukáš Thomes, Simona Remišová, Miroslav Dragoun, Markéta Berčíková, Vladimír Filip   +5 more
doaj   +1 more source

O Ensino de Ciências Naturais e a Construção de um Currículo Educacional Antirracista na Escola Bernardino Pereira de Barros, Abaetetuba-PA

Revista Insignare Scientia, 2020
Objetiva-se apresentar pesquisa realizada com professores do Ensino Fundamental sobre a Lei 10.639/2003 e suas aplicações na prática pedagógica. Os novos desafios do Ensino de Ciências Naturais estão intrinsecamente ligados ao desenvolvimento de novos ...
Deusa Maria de Sousa, Clemerson Santos da Silva, Rosicleide Maciel dos Santos   +2 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source