Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
National Atmospheric Deposition Program 2015 Annual summary [PDF]
, 2016 The National Atmospheric Deposition Program (NADP) provides fundamental measurements that support informed decisions on environmental issues related to precipitation and atmospheric deposition chemistry, as well as atmospheric mercury and ammonia.
core +1 more source
Conserved function of the long noncoding RNA Blnc1 in brown adipocyte differentiation
Molecular Metabolism, 2017 Objective: Long noncoding RNAs (lncRNAs) are emerging as important regulators of diverse biological processes. Recent work has demonstrated that the inducible lncRNA Blnc1 stimulates thermogenic gene expression during brown and beige adipocyte ...
Lin Mi +4 more
doaj +1 more source
Clinical aspects of epicardial fat deposition [PDF]
Vnitřní lékařství, 2020 Obesity is a chronic metabolic disease which is characterized by an increased body fat. Obesity increases cardiovascular morbidity and mortality and presents an important socioeconomic burden for the health system. So-called “central-android-abdominal-visceral” obesity plays an important role in the development of cardiovascular diseases ...
openaire +2 more sources
Protein and fat deposition in pigs in relation to bodyweight gain and feeding level [PDF]
, 1974 In pig breeding it is quite common to select for bodyweight gain, feed conversion and slaughter quality. Various values have been found by different research- workers for the relationships between these traits.
Cöp, W.A.G., Coep, W.A.G.
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Peripheral Neuropathy and Hindlimb Paralysis in a Mouse Model of Adipocyte-Specific Knockout of Lkb1
EBioMedicine, 2017 Brown adipose tissues (BAT) burn lipids to generate heat through uncoupled respiration, thus representing a powerful target to counteract lipid accumulation and obesity.
Yan Xiong +13 more
doaj +1 more source
Conventional and deep-litter pig production systems: the effects on fat deposition and distribution in growing female large white X landrace pigs [PDF]
, 2008 Minimising variability in carcass quality to better meet market specifications is a priority for Australian pig producers, however issues with variability in carcass fat distribution have recently been raised, particularly in the belly primal.
Trezona-Murray, Megan
core
Relationship of Serum Bile Acids with Fat Deposition in the Pancreas, Liver, and Skeletal Muscle
, 2023 Zena Al-Ani, Juyeon Ko, Maxim S Petrov Department of Surgery, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New ZealandCorrespondence: Maxim S Petrov, Email max.petrov@gmail.comIntroduction: Ectopic fat deposition is well ...
Al-Ani Z, Petrov MS, Ko J
core
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source