Results 61 to 70 of about 125,958 (301)

Eccentric contraction during gait is associated with muscle fat replacement in Duchenne Muscular Dystrophy

open access: yes, 2022
Duchenne Muscular Dystrophy (DMD) is a neuromuscular disorder characterized by progressive muscle weakness as well as progressive muscle fat replacement.
Boon, Ruben (author)
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

The effect of GH replacement therapy on different fat compartments: a whole-body magnetic resonance imaging study

open access: yes, 2011
Patients with GH deficiency (GHD) are insulin resistant with an increase in visceral fat mass (FM). Whether this holds true when sedentary control subjects (CS) are matched for waist has not been documented.
E R Christ   +11 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Impact of foods with health logo on ssaturated fat, sodium and sugar intake of young Dutch adults

open access: yes, 2011
Objective Health logos are introduced to distinguish foods with ‘healthier’ nutrient composition from regular foods. In the present study, we evaluated the effects of changed food compositions according to health logo criteria on the intake of saturated ...
Bulder, A.   +8 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

THE ESTIMATION OF CARCASS TRAITS OF BALI BULLS USING ULTRASOUND [PDF]

open access: yes, 2010
A study was conducted to collect information on Bali bulls carcass traits estimation as one of the selection criteria using ultrasound. Ultrasonic estimation of carcass traits such as M. longissimus thoracis area (MLTA), Subcutaneous Fat Thickness (SFT)
Sri Rachma, AB, Harada, H
core  

Dietary fat intake and obesity : an empirical study in Greek adults. [PDF]

open access: yes
The empirical evidence concerning the associations between diet, particularly fat intake, and obesity is inconclusive. The aim of the present study was to investigate cross-sectional associations between general and central ...
Lagiou, Areti
core   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

open access: yesFEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar   +4 more
wiley   +1 more source

Quality of Low Fat Chicken Nuggets: Effect of Sodium Chloride Replacement and Added Chickpea ( L.) Hull Flour [PDF]

open access: yesAsian-Australasian Journal of Animal Sciences, 2012
While attempting to develop low salt, low fat and high fibre chicken nuggets, the effect of partial (40%) common salt substitution and incorporation of chickpea hull flour (CHF) at three different levels viz., 5, 7.5 and 10% (Treatments) in pre ...
Arun K. Verma   +2 more
doaj   +1 more source

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