Results 61 to 70 of about 1,253,544 (212)

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Channelrhodopsins with distinct chromophores and binding patterns

Nature Communications
Channelrhodopsins are popular optogenetic tools in neuroscience, but remain poorly understood mechanistically. Here we report the cryo-EM structures of channelrhodopsin-2 (ChR2) from Chlamydomonas reinhardtii and H.
Yuanyue Shan, Liping Zhao, Meiyu Chen, Xiao Li, Mingfeng Zhang, Duanqing Pei   +5 more
doaj   +1 more source

Quantifying sources of variability in neonicotinoid residue data for assessing risks to pollinators

Julius-Kühn-Archiv, 2018
The U.S. Environmental Protection Agency’s 2014 guidance for assessing pesticide risks to bees relies on higher-tier studies of residues in pollen and nectar to refine pesticide exposure estimates obtained from lower tier information (e.g., default ...
Sappington, Keith, Mroz, Ryan, Garber, Kris, Farruggia, Frank, Wagman, Michael, Blankinship, Amy, Koper, Chris   +6 more
doaj   +1 more source

Identifying multicellular spatiotemporal organization of cells with SpaceFlow

Nature Communications, 2022
A critical task in spatial transcriptomics analysis is to understand inherently spatial relationships among cells. Here, the authors present a deep learning framework to integrate spatial and transcriptional information, spatially extending pseudotime ...
Honglei Ren, Benjamin L. Walker, Zixuan Cang, Qing Nie   +3 more
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Fate of $Z_2$ Symmetric Scalar Field

, 2013
The evolution of a coherently oscillating scalar field with $Z_2$ symmetry is studied in detail. We calculate the dissipation rate of the scalar field based on the closed time path formalism.
Mukaida, Kyohei, Nakayama, Kazunori, Takimoto, Masahiro   +2 more
core   +1 more source

Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani, Lakshmi Pillai, Reid D. Landes, Aliyah Glover, Shannon Doerhoff, Jennifer Kleiner, Mitesh Lotia, Rohit Dhall, Edgar Garcia‐Rill   +8 more
wiley   +1 more source

Advancing Research on Biomaterials and Biological Materials with Scanning Electron Microscopy under Environmental and Low Vacuum Conditions

Advanced Engineering Materials, EarlyView.
Herein, environmental scanning electron microscopy (ESEM) is discussed as a powerful extension of conventional SEM for life sciences. By combining high‐resolution imaging with variable pressure and humidity, ESEM allows the analysis of untreated biological materials, supports in situ monitoring of hydration‐driven changes, and advances the functional ...
Jendrian Riedel, Lea Dierker, Antoine Eyram Kwame, Kim Nora Wagner, Jonas J. Unterholzner, Jan‐Henning Dirks, Dorothea Brüggemann   +6 more
wiley   +1 more source

Regulated repression governs the cell fate promoter controlling yeast meiosis

Nature Communications, 2020
In budding yeast, the decision to enter meiosis is defined by nutrient and mating-type signals regulating expression of the master transcription factor for meiotic entry, IME1.
Janis Tam, Folkert J. van Werven
doaj   +1 more source

The Fate of the Accelerating Universe

, 2005
The presently accelerating universe may keep accelerating forever, eventually run into the event horizon problem, and thus be in conflict with the superstring idea.
A. R. Liddle, J. D. Barrow, Je-An Gu, N. Arkani-Hamed, W-Y. P. Hwang   +4 more
core   +1 more source