Results 171 to 180 of about 799,214 (269)

Integration of GWAS and eQTL analysis reveals regulatory CNVs for fatty acid traits in cattle. [PDF]

iScience
Liu F, Wu T, Wu J, Niu Q, Su Y, Zhao Z, Gong H, Gao H, Li J, Zhu B, Xu L.   +10 more
europepmc   +1 more source

HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism

Advanced Science, EarlyView.
Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang, Qingfei Meng, Hui Jiao, Huixin Liu, Xiangchao Wang, Honglan Zhou, Yishu Wang   +6 more
wiley   +1 more source

Fatty Acid Metabolism in Health and Cancer: From Fundamental Mechanisms to Therapeutic Application. [PDF]

MedComm (2020)
Hang N, Zhao R, Zhang F, Guo D, Li Q, Shen Z, Gao R, Gao C, Xie Z, Fu S, Luo P, Tang B, Wang L.   +12 more
europepmc   +1 more source

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

Serum fatty acid profiles across clinicopathologic heterogeneity in breast cancer: an exploratory study. [PDF]

Ther Adv Med Oncol
Mucha PT, Jedrzejewska A, Pakiet A, Jablonska P, Zielinski J, Szczecinska W, Puskulluoglu M, Mika A, Slominska EM, Tomczyk M.   +9 more
europepmc   +1 more source

m6A‐Mediated Glycolysis by IL‐37 Drives T Cell Metabolic Reprogramming to Regulate Colitis

Advanced Science, EarlyView.
This study identifies an IL‐37/SIGIRR‐METTL14 regulatory axis that suppresses global m6A modification in CD4+ T cells. IL‐37 signaling, mediated through SIGIRR, inhibits IRAK4 and JNK phosphorylation, leading to downregulation of the methyltransferase METTL14.
Xiaoyan Wang, Jiadong Yu, Guolin Li, Ya Li, Fanlian Zeng, Jing Hu, Yifan Zhou, Chengcheng Yue, Qixiang Zhao, Chen Zhang, Hong Zhou, Fulei Zhao, Yawen Hu, Pei Zhou, Linna Gu, Yuting Feng, Mingxiang He, Shishi Huang, Xiaochi Sun, Xinmeng Wang, Jie Tang, Xinyu Zeng, Wenling Wu, Nongyu Huang, Xinai Cui, Kaijun Cui, Jiong Li   +26 more
wiley   +1 more source

Krüppel-like factor 14 enhances fatty acid oxidation to combat pulmonary fibrosis. [PDF]

Respir Res
Ren J, Wan R, Zhou S, Ma X, Zhu C, Ma J, Chen J, Zhao L, Wu W.   +8 more
europepmc   +1 more source

Synthetic Toll‐Like Receptors for Control of Innate Immunity With Far‐Red Light

Advanced Science, EarlyView.
Synthetic Toll‐like receptors (TLRs) are engineered by replacing their natural sensing regions with a far‐red‐light‐responsive module from a bacterial phytochrome. These synthetic receptors enable light‐controlled regulation of immune signaling in mammalian cells.
Anna V. Leopold, Vladislav V. Verkhusha
wiley   +1 more source

Fabrication and thermal performance of ternary fatty acid/expanded graphite form-stable composite phase change materials. [PDF]

iScience
Zhou D, Yuan J, Zhou F, Liu Y.
europepmc   +1 more source