Results 71 to 80 of about 544,495 (306)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Can heart tissue fatty acid profile be used as a tool to discriminate sea lamprey (Petromyzon marinus, L.) populations in several Portuguese river basins? [PDF]

, 2011
This study proposes to evaluate the use of heart tissue fatty acid signature and multivariate analysis of fatty acid profile as a possible discriminating tool for sea lamprey P. marinus populations sampled in Portuguese river basins.
Almeida, P.R., Alves-Pereira, I., Ferreira, R., Lança, M.J., Machado, M., Mateus, C., Quintella, B.R.   +6 more
core  

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Influence of milling pH and storage on quality characteristics, mineral and fatty acid profile of buffalo Mozzarella cheese

Lipids in Health and Disease, 2019
Background Currently, cheese fat is a major component of human diet due to change in eating habits. It contains a number of health destroying as well as health promoting fatty acids. Bovine milk cheese fatty acid composition is regulating by many factors.
Nabila Gulzar, Saima Rafiq, Muhammad Nadeem, Muhammad Imran, Anjum Khalique, Iqra Muqada Sleem, Tahir Saleem   +6 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Fatty Acid Profiling of Major Fatty Acids in Safflower Genotype

Journal of Advances in Biology & Biotechnology
Fatty acid profiling is a process of analyzing the composition and quantity of different fatty acids. Fatty acids are organic molecules that are essential for a variety of biological processes in the body, including energy storage and membrane function. Safflower seed contains major four fatty acids viz.
V.L., Ghare, S. R., Bhalerao, D. N., Damse   +2 more
openaire   +2 more sources

Fatty acid profiles of the main lipid classes of green seaweeds from fish pond aquaculture [PDF]

, 2017
The lipid composition of five species of green seaweeds (Chaetomorpha linum, Rhizoclonium riparium, Ulva intestinalis, Ulva lactuca, and Ulva prolifera) grown in fish pond aquaculture systems was studied.
Bandarra, Bligh, Brockerhoff, Chopin, Cohen, Dawczynski, Edwards, El Maghraby, Ginneken, Gressler, Hayden, Kendel, Khotimchenko, Kumari, Largo, Lepage, Maehre, Mendoza Guzmán, Newton, Rajasulochana, Sato, Schuchardt, Senso, Soler-Vila, Valentine   +24 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Season and altitude effects on milk fatty acid profile in Sarda dairy sheep flocks [PDF]

, 2007
Diet plays a major role in modulating the fatty acid composition of ruminant milk. It is also well known that the intake of fresh forages has a positive influence on polyunsaturated fatty acid (PUFA), particularly CLA and omega- 3, compared with diets ...
Garau, Giovanni, Mangia, Nicoletta Pasqualina, Murgia, Marco Ambrogio, Nudda, Anna, Rubattu, Roberto   +4 more
core