Results 121 to 130 of about 4,584 (262)

Dapagliflozin alleviates high‐fat‐induced obesity cardiomyopathy by inhibiting ferroptosis

ESC Heart Failure, Volume 12, Issue 2, Page 1358-1373, April 2025.
Abstract Aim: Dapagliflozin (Dapa) is a novel hypoglycaemic agent with multiple cardiovascular protective effects, and it is widely used in treatment of heart failure patients, but whether it can improve obese phenotype of heart failure and its mechanism is still unclear.
Di Chen, Jiahao Shi, Yue Wu, Lizhu Miao, Zilin Wang, Yixuan Wang, Siwei Xu, Yu Lou   +7 more
wiley   +1 more source

Efficient Synthesis of Cannabinoid Acids

European Journal of Organic Chemistry, EarlyView.
In this study, an alternative synthesis of cannabinoid acids was developed based on an O→C acyl rearrangement. Specifically, this strategy involved regioselective bromination followed by halogen–lithium exchange and intramolecular nucleophilic addition, which led to successful carboxylation.
Ryosuke Arai, Hikari Nishiguchi, Kayo Nakamura, Hiroko Abe, Akihiko Ishida, Manabu Tokeshi, Kyohei Higashi, Akiyoshi Saitoh, Hideyo Takahashi   +8 more
wiley   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

A Cuproptosis Nanoparticle Reverses Lung Adenocarcinoma Drug Resistance

Exploration, EarlyView.
Copper‐based nanoparticles offer a promising strategy to improve treatment for KRAS‐mutated lung adenocarcinoma. These nanoparticles release copper ions in acidic environments, triggering copper‐dependent cell death and reducing ATP7B expression.
Leilei Wu, Kun Li, Han Wang, Shangshang Ma, Rangrang Wang, Yongfei Fan, Xichun Qin, Mingjun Li, Diego Gonzalez‐Rivas, Xiuru Ji, Dalong Ni, Dong Xie   +11 more
wiley   +1 more source

Advances in Anthocyanin Recovery and Purification From Natural Sources: Bioavailability, Mechanistic Action in the Human Body and Applications in Novel Food Development

Food Chemistry International, EarlyView.
This review highlights green recovery, purification, stabilisation, bioavailability, health relevance, and novel food applications of anthocyanins from natural and agro‐industrial sources. ABSTRACT Anthocyanins are water‐soluble natural pigments and multifunctional food ingredients that support clean‐label colour, antioxidant activity, and value‐added ...
Chandan Kumar Sahu, Soumitra Banerjee, Venkata Krishna Bayineni, Ravi‐Kumar Kadeppagari, Amit Arora   +4 more
wiley   +1 more source

Alternative protein sources: Extraction, modification and strategies for developing sustainable high‐quality food products

Food Biomacromolecules, EarlyView.
Novel Protein Sources: Strategies and Challenges for Product Formulation Abstract Search for alternative protein sources has intensified in the recent years, owing to the increasing population, demand for sustainable food systems and consumer's shift towards healthier diet choices.
Prem Sankaran, Baskaran Nagarethinam, Sunil Chikkaballapur Krishnappa, Chandrasekar Veerapandian, Ashish Rawson   +4 more
wiley   +1 more source

Enantiomeric Separation of Triacylglycerols Consisting of Three Different Fatty Acyls and Their Chiral Chromatographic Elution Behavior. [PDF]

Anal Chem
Zhang Y, Kalpio M, Haraldsdóttir H, Gudmundsson HG, Haraldsson GG, Sigurjónsson S, Kristinsson B, Linderborg KM, Yang B.   +8 more
europepmc   +1 more source

Oral microbiome-metabolome axis links glycerophospholipid dysregulation to Alzheimer's disease. [PDF]

J Oral Microbiol
Jia M, Yang R, Xu Y, Wu Z, Lu J, Li Z, Yan Q, Fan G, Gui Y.   +8 more
europepmc   +1 more source

Lipidomic Profiling of Commercial <i>Hydnocarpus wightianus</i> Oil by UPLC-QTOF-MS/MS and GC-MS: Degradation-Associated Lipid Classes as Candidate Quality Attributes for a Non-Pharmacopoeial Excipient. [PDF]

Molecules
Balwierz R, Schäfer N, Kuropka P, Wiśniewski J, Wieczorek D, Biernat P, Lipok J.   +6 more
europepmc   +1 more source

Tissue-Specific Detection of Autophagy and the Related Metabolites in <i>Bombyx mori</i>. [PDF]

Insects
Zhong Q, Hu J, Ahmad S, Xie X, Li K, Yi H, Tian L.   +6 more
europepmc   +1 more source