Results 1 to 10 of about 26,416 (261)

Altered Sphingolipids, Glycerophospholipids, and Lysophospholipids Reflect Disease Status in Idiopathic Steroid-Sensitive Nephrotic Syndrome in Children: A Non-Targeted Metabolomic Study [PDF]

Cells
Idiopathic steroid-sensitive nephrotic syndrome (ISSNS) is the most common glomerular disease in children, yet its molecular mechanisms and lipid-mediated pathophysiology remain poorly understood.
Takahiro Kanai, Hideo Ogiso, Jun Aoyagi, Masanori Kurosaki, Tomomi Maru, Marika Ishii, Kazuya Tanimoto, Mitsuaki Yoshino, Yuri Yamashita, Toshihiro Tajima, Ryozo Nagai, Kenichi Aizawa   +11 more
doaj   +2 more sources

Metabolomics Reveals Glycerophospholipids, Peptides, and Flavonoids Contributing to Breast Meat Flavor and Benefit Properties of Beijing-You Chicken

Foods
Unique metabolites contribute to the performance of meat flavor and potential function. In this study, UHPLC-Q Exactive HF-X-based metabolomics and multivariate analysis were applied to explore the characteristic metabolites in the breast meat of Beijing-
Jian Zhang, Xia Chen, Jing Cao, Ailian Geng, Qin Chu, Zhixun Yan, Yao Zhang, Huagui Liu   +7 more
doaj   +3 more sources

A serum metabolomics study of vascular cognitive impairment patients based on Traditional Chinese medicine syndrome differentiation

Frontiers in Molecular Biosciences, 2023
Objective: Vascular cognitive impairment (VCI) accounts for approximately 50%–70% of all dementia cases and poses a significant burden on existing medical systems.
Li Liu, Yi-fei Qi, Min Wang, Bao-xin Chen, Qing-bing Zhou, Wen-xin Tong, Ying Zhang   +6 more
doaj   +1 more source

Remodeling of the Enterococcal Cell Envelope during Surface Penetration Promotes Intrinsic Resistance to Stress

mBio, 2022
Enterococcus faecalis is a normal commensal of the human gastrointestinal tract (GIT). However, upon disruption of gut homeostasis, this nonmotile bacterium can egress from its natural niche and spread to distal organs.
Yusibeska Ramos, Stephanie Sansone, Sung-Min Hwang, Tito A. Sandoval, Mengmeng Zhu, Guoan Zhang, Juan R. Cubillos-Ruiz, Diana K. Morales   +7 more
doaj   +1 more source

FACS-assisted single-cell lipidome analysis of phosphatidylcholines and sphingomyelins in cells of different lineages

Journal of Lipid Research, 2023
Recent advances in single-cell genomics and transcriptomics technologies have transformed our understanding of cellular heterogeneity in growth, development, ageing, and disease; however, methods for single-cell lipidomics have comparatively lagged ...
Sarah E. Hancock, Eileen Ding, Emma Johansson Beves, Todd Mitchell, Nigel Turner   +4 more
doaj   +1 more source

Characterization of brain‐derived extracellular vesicle lipids in Alzheimer's disease

Journal of Extracellular Vesicles, 2021
Lipid dyshomeostasis is associated with the most common form of dementia, Alzheimer's disease (AD). Substantial progress has been made in identifying positron emission tomography and cerebrospinal fluid biomarkers for AD, but they have limited use as ...
Huaqi Su, Yepy H. Rustam, Colin L. Masters, Enes Makalic, Catriona A. McLean, Andrew F. Hill, Kevin J. Barnham, Gavin E. Reid, Laura J. Vella   +8 more
doaj   +1 more source

Metabolomics of dietary fatty acid restriction in patients with phenylketonuria [PDF]

, 2012
Patients with phenylketonuria (PKU) have to follow a lifelong phenylalanine restricted diet. This type of diet markedly reduces the intake of saturated and unsaturated fatty acids especially long chain polyunsaturated fatty acids (LC-PUFA).
Berthold Koletzko, Carmen Rohde, Claudia Matthies, Joachim Thiery, Linda Kortz, Mathias Bruegel, Michael Müller, Skadi Beblo, Ulrike Mütze, Uta Ceglarek, Wieland Kiess   +10 more
core   +7 more sources

Cell Type Variability in the Incorporation of Lipids in the Dengue Virus Virion

Viruses, 2022
A lipid bilayer produced from the host membrane makes up around 20% of the weight of the dengue virus (DENV) virion and is crucial for virus entry. Despite its significance, the virion’s lipid composition is still poorly understood.
Atitaya Hitakarun, Maia Kavanagh Williamson, Nathamon Yimpring, Wannapa Sornjai, Nitwara Wikan, Christopher J. Arthur, Julien Pompon, Andrew D. Davidson, Duncan R. Smith   +8 more
doaj   +1 more source

Roles of polyunsaturated fatty acids, from mediators to membranes

Journal of Lipid Research, 2020
PUFAs, such as AA and DHA, are recognized as important biomolecules, but understanding their precise roles and modes of action remains challenging. PUFAs are precursors for a plethora of signaling lipids, for which knowledge about synthetic pathways and ...
Takeshi Harayama, Takao Shimizu
doaj   +1 more source

Arachidonic acid mobilization among phospholipids in murine mastocytoma P-815 cells: role of ether-linked phospholipids.

Journal of Lipid Research, 1990
The ethanolamine-containing glycerophospholipids, choline-containing glycerophospholipids, and phosphatidylinositol fractions are major sources of arachidonic acid in murine mastocytoma P-815 cloned cells.
S Yoshioka, S Nakashima, Y Okano, Y Nozawa   +3 more
doaj   +1 more source