Results 21 to 30 of about 21,259 (271)

Modulation of the activity of cytosolic phospholipase A2α (cPLA2α) by cellular sphingolipids and inhibition of cPLA2α by sphingomyelin[S]

Journal of Lipid Research, 2010
We examined the effect of the cellular sphingolipid level on the release of arachidonic acid (AA) and activity of cytosolic phospholipase A2α (cPLA2α) using two Chinese hamster ovary (CHO)-K1-derived mutants deficient in sphingolipid synthesis: LY-B ...
Hiroyuki Nakamura, Shigeo Wakita, Akiko Suganami, Yutaka Tamura, Kentaro Hanada, Toshihiko Murayama   +5 more
doaj   +1 more source

Lipid profiling of FPLC-separated lipoprotein fractions by electrospray ionization tandem mass spectrometry[S]

Journal of Lipid Research, 2009
Glycerophospholipid and sphingolipid species and their bioactive metabolites are important regulators of lipoprotein and cell function. The aim of the study was to develop a method for lipid species profiling of separated lipoprotein classes. Human serum
Philipp Wiesner, Katharina Leidl, Alfred Boettcher, Gerd Schmitz, Gerhard Liebisch   +4 more
doaj   +1 more source

Marine Plasmalogens: A Gift from the Sea with Benefits for Age-Associated Diseases

Molecules, 2023
Aging increases oxidative and inflammatory stress caused by a reduction in metabolism and clearance, thus leading to the development of age-associated diseases. The quality of our daily diet and exercise is important for the prevention of these diseases.
Shinji Yamashita, Taiki Miyazawa, Ohki Higuchi, Mikio Kinoshita, Teruo Miyazawa   +4 more
doaj   +1 more source

Self‐glycerophospholipids activate murine phospholipid‐reactive T cells and inhibit iNKT cell activation by competing with ligands for CD1d loading [PDF]

, 2019
Glycosphingolipids and glycerophospholipids bind CD1d. Glycosphingolipid-reactive invariant NKT-cells (iNKT) exhibit myriad immune effects, however, little is known about the functions of phospholipid-reactive T cells (PLT).
Tatsuya Ishikawa, Cynthia Tran, Dirk M. Zajonc, Ishikawa, Tatsuya, Wang, Meiying, Jing Wang, Ramesh Chandra Halder, Priti Prasad, Wang, Jing, Meiying Wang, Prasad, Priti, Ram Raj Singh, Halder, Ramesh Chandra, Nallapothula, Dhiraj, Tran, Cynthia, Zajonc, Dirk M, Singh, Ram Raj, Dhiraj Nallapothula   +17 more
core   +1 more source

Three-dimensional enhanced lipidomics analysis combining UPLC, differential ion mobility spectrometry, and mass spectrometric separation strategies1[S]

Journal of Lipid Research, 2014
Phospholipids serve as central structural components in cellular membranes and as potent mediators in numerous signaling pathways. There are six main classes of naturally occurring phospholipids distinguished by their distinct polar head groups that ...
Paul R.S. Baker, Aaron M. Armando, J. Larry Campbell, Oswald Quehenberger, Edward A. Dennis   +4 more
doaj   +1 more source

Effects of a 12-week whole-grain or refined wheat intervention on plasma acylcarnitines, bile acids and signaling lipids, and association with liver fat: A post-hoc metabolomics study of a randomized controlled trial

Frontiers in Nutrition, 2022
BackgroundWe previously showed that whole-grain wheat (WGW) consumption had beneficial effects on liver fat accumulation, as compared to refined wheat (RW).
Anouk Gijbels, Sophie Schutte, Diederik Esser, Suzan Wopereis, Gerard Bryan Gonzales, Lydia A. Afman   +5 more
doaj   +1 more source

Sphingolipids and glycerophospholipids - The "ying and yang" of lipotoxicity in metabolic diseases [PDF]

, 2017
Sphingolipids in general and ceramides in particular, contribute to pathophysiological mechanisms by modifying signalling and metabolic pathways. Here, we present the available evidence for a bidirectional homeostatic crosstalk between sphingolipids and ...
Pellegrinelli, V.,, V. Pellegrinelli, A. Vidal-Puig, Oresic, Matej,, M. Oresic, M. Campbell, Rodriguez-Cuenca, S.,, Campbell, M.,, Vidal-Puig, A.,, S. Rodriguez-Cuenca   +9 more
core   +2 more sources

Asymmetric glycerophospholipids impart distinctive biophysical properties to lipid bilayers

, 2021
Phospholipids are a diverse group of biomolecules consisting of a hydrophilic headgroup and two hydrophobic acyl tails. The nature of the head and length and saturation of the acyl tails are important for defining the biophysical properties of lipid ...
Makarova, Maria, Smith, Paul, Lorenz, Christian D., Owen, Dylan M., Lorenz, Christian D.; id_orcid, Paul Smith, Christian D. Lorenz, Maria Makarova, Dylan M. Owen   +8 more
core   +1 more source

The Effects of Consuming White Button Mushroom Agaricus bisporus on the Brain and Liver Metabolome Using a Targeted Metabolomic Analysis

Metabolites, 2021
A targeted metabolomic analysis was performed on tissues derived from pigs fed diets supplemented with white button mushrooms (WBM) to determine the effect on the liver and brain metabolome.
Gloria I. Solano-Aguilar, Sukla Lakshman, Saebyeol Jang, Richi Gupta, Aleksey Molokin, Steven G. Schroeder, Patrick M. Gillevet, Joseph F. Urban   +7 more
doaj   +1 more source

Two dimensional chromatography of glycerophospholipids.

, 2013
The levels of all major glycerophospholipids were diminished by treatment with simvastatin. Panels: 1, 3, 5 glycerophospholipids from cells harbouring the wild-type yeast, or the wild-type or mutated hHMGR gene, respectively.
Beata Burzynska (117208), Magdalena Zimnicka (368153), Marek Kiliszek (117207), Monika Wysocka-Kapcinska (368157), Joanna Kaminska (318202), Agata Leszczynska (117214), Witold Danikiewicz (368159), Magdalena Kania (368155), Danuta Plochocka (160143), Anna Szkopinska (368161)   +9 more
core   +1 more source