Results 171 to 180 of about 4,584 (262)

Toll‐Like Receptor 4 Signaling in Natural N‐Acylethanolamines and Derivative NAE‐Like Compounds: Mechanisms and Implications for Neuroimmune and Inflammatory Processes in a Systematic Search Approach

Phytotherapy Research, EarlyView.
ABSTRACT N‐acylethanolamines (NAEs) are endogenous fatty acid amides structurally related to the endocannabinoid anandamide and function as bioactive lipid mediators with broad regulatory roles in inflammation and neuroinflammation. Among pattern‐recognition receptors, Toll‐like receptor 4 (TLR4) occupies a central position in innate immune ...
Damiana Scuteri, Francesca Guida, Giacinto Bagetta, Sabatino Maione, Maria Tiziana Corasaniti, Morena Zusso   +5 more
wiley   +1 more source

Identification of a novel metabolic and lipidomic signature for 90-day functional outcome after ischemic stroke: an exploratory proof-of-concept study. [PDF]

Front Neurol
Wang T, Ji J, Wang M, Fan R, Ye Y, Zhang S, Wu S, Zhang L, Fang J.   +8 more
europepmc   +1 more source

6‐Shogaol Promotes Fatty Acid Oxidation and Osteogenic Differentiation in Aged Bone Marrow Mesenchymal Stem Cells Through Allosteric Regulation of Carnitine Palmitoyltransferase 1A

Phytotherapy Research, EarlyView.
ABSTRACT Age‐related osteoporosis is heavily driven by the senescent decline of bone marrow mesenchymal stem cells (BMSCs), characterized by impaired osteogenic differentiation and excessive lipid accumulation. Defective fatty acid oxidation (FAO) is a critical metabolic hallmark of this pathogenic shift.
Yining Zhao, Jianhang Wang, Yuankun Zhang, Zhuohan Cao, Congcong Xu, Hongming Zhou, Liang Ma, Yongchang Tang   +7 more
wiley   +1 more source

Untargeted serum metabolomic profiling reveals altered choline-phospholipid and amino acid metabolism in patients receiving subcostal transversus abdominis plane block combined with general anesthesia for radical gastrectomy: A prospective comparative study. [PDF]

J Int Med Res
Chen X, Lin X, Li Q, Qiu X, Lin J.
europepmc   +1 more source

Butin Ameliorates Atherosclerosis by Regulating the TIMM13‐TIMM8A Complex to Alleviate Macrophage Ferroptosis

Phytotherapy Research, EarlyView.
The natural flavonoid Butin selectively targets the mitochondrial translocase subunit TIMM13 at residue Asn34, competitively disrupting the pathological TIMM13‐TIMM8A complex. This targeted engagement halts mitochondrial iron influx, reactivates the SLC7A11/GPX4 antioxidant cascade, and attenuates macrophage ferroptosis and foam cell formation ...
Dashuai Wang, Xinyi Yu, Mingjie Xie, Gongcheng Huang, Zhenxing Liang, Chen Huang, Hai Liu   +6 more
wiley   +1 more source

Comparison of Nutritional Profiles and Antioxidant Capacity in the Muscle of <i>Procambarus clarkii</i> Farmed Across Various Rice Paddy Regions in Eastern China. [PDF]

Antioxidants (Basel)
Zhou L, Ding C, Jia R, Hou Y, Zhang C, Zhang L, Li B, Zhu J.   +7 more
europepmc   +1 more source

Polyphyllin I Alleviates Alcoholic Liver Disease via Modulation of the Phosphodiesterase 6D–Cyclic Guanosine Monophosphate–Protein Kinase G Axis

Phytotherapy Research, EarlyView.
ABSTRACT Alcoholic liver disease (ALD) is a multifaceted disorder in which oxidative injury, iron‐dependent ferroptosis, steatosis, and inflammation are closely intertwined. Consequently, therapeutic strategies targeting a single pathway often produce limited clinical benefits.
Hongyan Feng, Xuelian Yuan, Yawen Xie, Zhenni Xia, Zhaohui Guo, Xuesong Liu, Rong Li, Wenliang Wang   +7 more
wiley   +1 more source

Lipidomic analysis of A1, A2, and heterozygous beta-casein genotypes in bovine milk using gas chromatography-mass spectrometry. [PDF]

Biochem Biophys Rep
Peres PABM, Filho MJ, Souza HOA, Martins MM, Nossol ABS, Caixeta DC, Demétrio AF, Reis TFM, Saito N, Brito-Madurro AG, Maduro JM, Alonso-Goulart V.   +11 more
europepmc   +1 more source

Influence of Dissolved Oxygen on the Gassing Tendency of Biodegradable Insulating Liquids Under Thermal and Electrical Faults

High Voltage, EarlyView.
ABSTRACT Dissolved gas analysis (DGA), widely used for fault diagnosis, can be significantly influenced by the presence of oxygen. Oxygen not only accelerates fluid degradation but also alters the type and concentration of fault gases generated, potentially leading to misinterpretation of transformer conditions if conventional DGA models are applied ...
Moïse Agouassi, U. Mohan Rao, Issouf Fofana, Yazid Hadjadj, Fethi Maghnefi   +4 more
wiley   +1 more source