Results 1 to 10 of about 586,099 (248)

Improved fatty aldehyde and wax ester production by overexpression of fatty acyl-CoA reductases [PDF]

Microbial Cell Factories, 2018
Background Fatty aldehydes are industrially relevant compounds, which also represent a common metabolic intermediate in the microbial synthesis of various oleochemicals, including alkanes, fatty alcohols and wax esters.
Tapio Lehtinen, Elena Efimova, Suvi Santala, Ville Santala   +3 more
doaj   +3 more sources

Monitoring of fatty aldehyde dehydrogenase by formation of pyrenedecanoic acid from pyrenedecanal

Journal of Lipid Research, 2010
Fatty aldehyde dehydrogenase (EC 1.2.1.48) converts long-chain fatty aldehydes to the corresponding acids. Deficiency in this enzyme causes the Sjogren Larsson Syndrome, a rare inherited disorder characterized by ichthyosis, spasticity, and mental ...
Ronald Wanders, Katrin Watschinger, Gabriele Werner-Felmayer   +2 more
exaly   +4 more sources

Studying fatty aldehyde metabolism in living cells with pyrene-labeled compounds

Journal of Lipid Research, 2012
The lack of fatty aldehyde dehydrogenase function in Sjögren Larsson Syndrome (SLS) patient cells not only impairs the conversion of fatty aldehydes into their corresponding fatty acid but also has an effect on connected pathways. Alteration of the lipid
Ronald Wanders, Katrin Watschinger, Gabriele Werner-Felmayer   +2 more
exaly   +4 more sources

Fatty aldehyde dehydrogenase, the enzyme downstream of tetrahydrobiopterin-dependent alkylglycerol monooxygenase

Pteridines, 2013
The tetrahydrobiopterin-dependent degradation of ether lipids by alkylglycerol monooxygenase (AGMO) produces fatty aldehydes, which are toxic to cells.
Katrin Watschinger, Gabriele Werner-Felmayer, Markus A Keller   +2 more
exaly   +2 more sources

Sjögren-Larsson syndrome: A biochemical rationale for using aldehyde-reactive therapeutic agents

Molecular Genetics and Metabolism Reports, 2022
Sjögren-Larsson syndrome (SLS) is a neurocutaneous disease caused by mutations in ALDH3A2 that result in deficient fatty aldehyde dehydrogenase (FALDH) activity and impaired fatty aldehyde and fatty alcohol oxidation.
William B. Rizzo, Dana S'aulis, Elizabeth Dorwart, Zachary Bailey   +3 more
doaj   +1 more source

Nuclear receptors NHR-49 and NHR-79 promote peroxisome proliferation to compensate for aldehyde dehydrogenase deficiency in C. elegans.

PLoS Genetics, 2021
The intracellular level of fatty aldehydes is tightly regulated by aldehyde dehydrogenases to minimize the formation of toxic lipid and protein adducts. Importantly, the dysregulation of aldehyde dehydrogenases has been implicated in neurologic disorder ...
Lidan Zeng, Xuesong Li, Christopher B Preusch, Gary J He, Ningyi Xu, Tom H Cheung, Jianan Qu, Ho Yi Mak   +7 more
doaj   +1 more source

Heterofermentative lactic acid bacteria such as Limosilactobacillus as a strong inhibitor of aldehyde compounds in plant-based milk alternatives

Frontiers in Sustainable Food Systems, 2022
Reduction of greenhouse gas emissions is important to limit climate change. Because ruminant animals emit greenhouse gases, the worldwide plant-based alternative market is an emerging trend for eating less meat and dairy products.
Hirosuke Sugahara, Sayaka Kato, Keitaro Nagayama, Koichi Sashihara, Yasushi Nagatomi   +4 more
doaj   +1 more source

Fatty aldehydes in cyanobacteria are a metabolically flexible precursor for a diversity of biofuel products. [PDF]

PLoS ONE, 2013
We describe how pathway engineering can be used to convert a single intermediate derived from lipid biosynthesis, fatty aldehydes, into a variety of biofuel precursors including alkanes, free fatty acids and wax esters.
Brett K Kaiser, Michael Carleton, Jason W Hickman, Cameron Miller, David Lawson, Mark Budde, Paul Warrener, Angel Paredes, Srinivas Mullapudi, Patricia Navarro, Fred Cross, James M Roberts   +11 more
doaj   +1 more source

Engineering an Alcohol-Forming Fatty Acyl-CoA Reductase for Aldehyde and Hydrocarbon Biosynthesis in Saccharomyces cerevisiae

Frontiers in Bioengineering and Biotechnology, 2020
Aldehydes are a class of highly versatile chemicals that can undergo a wide range of chemical reactions and are in high demand as starting materials for chemical manufacturing.
Jee Loon Foo, Jee Loon Foo, Bahareh Haji Rasouliha, Bahareh Haji Rasouliha, Adelia Vicanatalita Susanto, Adelia Vicanatalita Susanto, Susanna Su Jan Leong, Susanna Su Jan Leong, Susanna Su Jan Leong, Matthew Wook Chang, Matthew Wook Chang   +10 more
doaj   +1 more source

The Prokaryotic Microalga Limnothrix redekei KNUA012 to Improve Aldehyde Decarbonylase Expression for Use as a Biological Resource

Polish Journal of Microbiology, 2023
The prokaryotic microalga Limnothrix redekei KNUA012 isolated from a freshwater bloom sample from Lake Hapcheon, Hapcheon-gun, South Korea, was investigated for its potential as a biofuel feedstock.
Kim Young-Saeng, Baek Haeri, Yun Hyun-Sik, Lee Jae-Hak, Lee Kyoung-In, Kim Han-Soon, Yoon Ho-Sung   +6 more
doaj   +1 more source