Results 1 to 10 of about 779,655 (355)
陆军军医大学学报, 2023 Objective To explore the effect and molecular mechanism of artesunate (ART) on cholestatic liver fibrosis induced by 3, 5-diethoxycarbonyl-1, 4-dihydro-2, 4, 6-collidine (DDC).
TANG Wan +3 more
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Fatty liver index associates with relative sarcopenia and GH/ IGF- 1 status in obese subjects [PDF]
, 2016 Recently the association between hepatic steatosis and sarcopenia has been described. GH/IGF-1 axis has been postulated to play a role in linking fatty liver and low muscle mass.
Donini, Lorenzo Maria +5 more
core +7 more sources
陆军军医大学学报, 2023 Objective To screen and verify the Hub genes involved in conjugated bile acid-induced hepatocyte metabolism through transcriptome sequencing analysis. Methods Primary mouse hepatocytes were treated with taurocholic acid (TCA), and the gene expression of ...
ZHANG Mengni +4 more
doaj +1 more source
Frontiers in Nutrition, 2022 Recent studies have revealed that sarcopenia is closely associated with obesity and non-alcoholic steatohepatitis (NASH). However, few attempted to explore the cause-and-effect relationship between sarcopenic obesity and NASH.
Zi-Xuan Wang +9 more
doaj +1 more source
Surveillance of the progression and assessment of treatment endpoints for nonalcoholic steatohepatitis [PDF]
Clinical and Molecular Hepatology, 2023 Nonalcoholic steatohepatitis (NASH) is an aggressive form of nonalcoholic fatty liver disease (NAFLD) characterized by steatosis-associated inflammation and liver injury. Without effective treatment or management, NASH can have life-threatening outcomes.
Yi-wen Shi, Jian-Gao Fan
doaj +1 more source
Carrier-free curcumin nanoassemblies for enhancing therapy effects in inflammation related disease
Materials & Design, 2022 Hyperinflammation can lead to tissue injury, organ failure, and even fatalities by overproducing proinflammatory cytokines. The long-term safety and outstanding anti-inflammatory ability of natural products have attracted much attention, but the low ...
Liangjun Zhang +9 more
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Materials & Design, 2023 Acute liver injury (ALI) is one of the most important causes of liver failure, and there are no FDA-approved drugs that could therapy late-stage ALI. It has been shown in this study that HA-PEI, a molecule formed by covalently combining HA and PEI, can ...
Mingqiao Li +10 more
doaj +1 more source
Unique DUOX2+ACE2+ small cholangiocytes are pathogenic targets for primary biliary cholangitis
Nature Communications, 2023 The aetiology of primary biliary cholangitis (PBC) remains unclear. Here, the authors find that the numbers of DUOX2 + ACE2 + small cholangiocytes in human and mouse livers are inversely associated with disease severity, and present data indicating that ...
Xi Li +32 more
doaj +1 more source
Regulation of Lipid Metabolism by Lamin in Mutation-Related Diseases
Frontiers in Pharmacology, 2022 Nuclear lamins, known as type 5 intermediate fibers, are composed of lamin A, lamin C, lamin B1, and lamin B2, which are encoded by LMNA and LMNB genes, respectively.
Yue Peng +4 more
doaj +1 more source
Nonalcoholic Fatty Liver Disease [PDF]
Canadian Journal of Gastroenterology and Hepatology, 2018 According to the papers published in this special issue, NAFLD is a serious problem, which each author from their own aspect tried to clarify. Regarding the fact that NAFLD is rarely isolated and that it is correlated with obesity, diabetes type 2, polycystic ovarian syndrome, obstructive sleep apnea, and some cognitive deficits, its pathophysiology ...
Branka Filipović +3 more
openaire +5 more sources