Results 111 to 120 of about 395,992 (296)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Injection Current Distribution Characteristics Identification Based Distribution-Level Fault Line Selection

Zhongguo dianli
Addressing the challenges posed by the subtle characteristics of single-phase grounding faults in resonant grounding systems, which lead to decreased sensitivity and reliability in fault line selection methods reliant on these characteristics, an ...
Xiaowei WANG, Yang YUE, Liang GUO, Xue WANG, Yizhao WANG, Zhihua ZHANG, Fengfeng YANG   +6 more
doaj   +1 more source

Early warning fault detection using artificial intelligent methods [PDF]

, 1996
This paper describes a research investigation to access the feasibility of using an Artificial Intelligence (AI) method to predict and detect faults at an early stage in power systems. An AI based detector has been developed to monitor and predict faults
Ryan, H. M., Tindle, J., Wong, K. C. P.
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Time-Frequency Transformation Technique with Various Mother Wavelets for DC Fault Analysis in HVDC Transmission Systems

Sir Syed University Research Journal of Engineering and Technology, 2023
HVDC transmission has become a cost-effective option for transferring high voltage over greater distances. Protecting an HVDC transmission line is more challenging than protecting an AC transmission line due to its low impedance and absence of zero ...
Hasnain Raza chandio, Aslam Pervez Memon
doaj  

Communication Subsystems for Emerging Wireless Technologies [PDF]

, 2012
The paper describes a multi-disciplinary design of modern communication systems. The design starts with the analysis of a system in order to define requirements on its individual components.
Gotthans, T., Hrubos, Z., Kadlec, P., Kincl, Z., Klozar, L., Kolka, Zdeněk, Marsalek, R., Petrzela, J., Povalac, A., Prokes, A., Raida, Zbyněk, Sebesta, J., Sotner, R.   +12 more
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Differential Protection of Distribution Network Based on VMD and Duffing Oscillator

Zhongguo dianli
The distribution network is grounded through arc suppression coil. When a single-phase grounding fault occurs, the faulting characteristics are often weak and unobvious, which makes it difficult to accurately locate the fault line.
Jianbao ZHANG, Lei WANG, Weijian JIANG
doaj   +1 more source