Results 101 to 110 of about 395,992 (296)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Particle Swarm Optimization Framework for Low Power Testing of VLSI Circuits

, 2011
Power dissipation in sequential circuits is due to increased toggling count of Circuit under Test, which depends upon test vectors applied. If successive test vectors sequences have more toggling nature then it is sure that toggling rate of flip flops is
Khosla, Arun, Narang, Sukhleen Bindra, Singh, Balwnder   +2 more
core   +2 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

GA-SVM method for single-phase grounding fault line selection in distribution network based on feature fusion

Diance yu yibiao
Aiming at the low accuracy of line selection method when the data amount of single-phase grounding fault in distribution network is small, a genetic algorithm optimized support vector machine (GA-SVM) method for single-phase grounding fault line ...
ZHANG Xiaopeng, BAI Jie, SUN Naijun, LI Jie, ZHENG Shuai, WAN Qingzhu   +5 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

A novel fault line selection method based on empirical mode decomposition and differential spectrum

Gong-kuang zidonghua, 2013
The paper proposed a novel single-phase grounding fault line selection method of small current grounding system based on EMD and differential spectrum.
ZHENG Chen, WANG Xiao-wei, LIU Ya-juan, TIAN Shu   +3 more
doaj  

Fault line selection method for resonant grounding systems based on DTW-Hilbert and improved K-means

Gong-kuang zidonghua
Due to the influence of factors such as arc suppression coils, transition resistance, and environmental noise, the fault signal characteristics in resonant grounding systems are weak.
ZHANG Zhaoxi, ZHANG Hongle, HUANG Yanfa, CHEN Xingxiang, JIA Haicheng, YUAN Pengsheng   +5 more
doaj   +1 more source

Research on fault line selection method based on steady state variables

AIP Advances
When a single-phase ground fault occurs, the transient zero sequence current will significantly increase. So, it is possible to detect whether a single-phase grounding fault has occurred in the transmission line by calculating and comparing the amplitude of transient zero sequence current.
Sha Wang, Changsheng Liu, Shengkai Wei
openaire   +2 more sources