Results 111 to 120 of about 6,686,710 (281)
Installation locations of surge arresters on double-circuit transmission lines
Zhejiang dianliThe connected series-compensated capacitors alter the sequence network impedance of transmission lines and the distribution of sequence currents during faults.
YANG Liming +5 more
doaj +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
Two-Dimension Fault Line Selection Method Based on Transient Signal Features of Fault Phase
, 2011 When single-line-to-ground fault happen in neutral non-effectively earthed system, there is a big difference between the fault feeder and un-fault feeder in transient signal energy centralized frequency band and signal amplitude of fault phase.
Ying Wang +3 more
core +1 more source
Simulation Analysis of Single-phase Grounding Fault of Resonant Grounding System
Gong-kuang zidonghua, 2012 For problem of difficult line selection caused by small current of fault line with uncertain direction when single-phase grounding fault happens in resonant grounding system, the paper theoretically analyzed change law of zero-sequence voltage and zero ...
LI Hui, TANG Yi, SUN Chang-qing
doaj
Line selection method for mine small-current grounding based on optimized VMD and RF
Gong-kuang zidonghuaIn underground small-current grounding power supply systems, the decomposition performance of the single-phase grounding fault line selection method based on Variational Mode Decomposition (VMD) depends heavily on the selection of parameters such as the ...
ZHU Jun +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Detection and fault diagnosis of power transmission line in infrared image
, 2015 With surface aging and natural disasters, power transmission line often has broken strand fault which presents partial discharge and temperature rising. Infrared thermography is a new method to detect the temperature rising fault.
Li WT(李文涛) +4 more
core