Results 91 to 100 of about 6,686,710 (281)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

A novel fault line selection method based on empirical mode decomposition and differential spectrum

Gong-kuang zidonghua, 2013
The paper proposed a novel single-phase grounding fault line selection method of small current grounding system based on EMD and differential spectrum.
ZHENG Chen, WANG Xiao-wei, LIU Ya-juan, TIAN Shu   +3 more
doaj  

Fault line selection method for resonant grounding systems based on DTW-Hilbert and improved K-means

Gong-kuang zidonghua
Due to the influence of factors such as arc suppression coils, transition resistance, and environmental noise, the fault signal characteristics in resonant grounding systems are weak.
ZHANG Zhaoxi, ZHANG Hongle, HUANG Yanfa, CHEN Xingxiang, JIA Haicheng, YUAN Pengsheng   +5 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Injection Current Distribution Characteristics Identification Based Distribution-Level Fault Line Selection

Zhongguo dianli
Addressing the challenges posed by the subtle characteristics of single-phase grounding faults in resonant grounding systems, which lead to decreased sensitivity and reliability in fault line selection methods reliant on these characteristics, an ...
Xiaowei WANG, Yang YUE, Liang GUO, Xue WANG, Yizhao WANG, Zhihua ZHANG, Fengfeng YANG   +6 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

High-reliability fault tolerant digital systems in nanometric technologies: Characterization and design methodologies [PDF]

, 2012
This paper reports the main contribution of a project devoted to the definition of techniques to design and evaluate fault tolerant systems implemented using the SoPC paradigm, suitable for missionand safety-critical application environments.
Gerardin S., C. Metra, Rossi D, PACCAGNELLA, ALESSANDRO, Miele, A, Sterpone, Luca, Bagattin, M., S. Gerardin, Gerardin, S, Sandionigi C., Sterpone L., Sterpone L, Omana M., Salsano, A, ROSSI, DANIELE, Gerardin, S., Metra, C., GERARDIN, SIMONE, Bolchini, C, A. Miele, Ottavi M, Sonza Reorda, M., Bagatin M, Sandionigi, C, M. Bagatin, A. Paccagnella, MIELE, ANTONIO ROSARIO, Pontarelli, S., Miele A., C. Sandionigi, M. Violante, L. Sterpone, Gerardin S, Miele A, Paccagnella, A, Salsano A., Violante M, Ottavi M., Violante M., Bagatin, M., Sandionigi, C., Reorda M, SALSANO, ADELIO, Pontarelli S, OMANA, MARTIN EUGENIO, Bolchini, C., BAGATIN, MARTA, Bagatin M., C. Bolchini, Violante, M., Salsano A, Omana, M, Bagatin, M, Sonza Reorda M, Rossi D., Reorda, M, Paccagnella A., Omana, M., A. Salsano, PONTARELLI, SALVATORE, Violante, Massimo, S. Pontarelli, BOLCHINI, CRISTIANA, Metra C., Bolchini C, Omana M, Miele, A., Paccagnella, A., D. Rossi, Pontarelli S., Pontarelli, S, M. Ottavi, Reorda M. S., Reorda, M. Sonza, Sterpone, L., Sterpone, L, M. Sonza Reorda, Violante, M, Salsano, A., Sandionigi C, METRA, CECILIA, Metra, C, Ottavi, M., Rossi, D, OTTAVI, MARCO, M. Omana, Sonza Reorda, Matteo, Paccagnella A, Ottavi, M, Rossi, D., Bolchini C., Metra C   +91 more
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

A framework and methods for on-board network level fault diagnostics in automobiles [PDF]

A significant number of electronic control units (ECUs) are nowadays networked in automotive vehicles to help achieve advanced vehicle control and eliminate bulky electrical wiring.
Suwatthikul, Jittiwut
core  

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source