Results 71 to 80 of about 6,686,710 (281)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Research of Fault Line Selection Method of Distribution Network Based on Transient Zero-sequence Energy

Gong-kuang zidonghua, 2012
For problem of ineffectiveness of traditional line selection methods by use of single feature value caused by complex and random fault borderline, small steady component of fault and reverse phase of instantaneous zero-sequence power when single-phase ...
TIAN Shu, HE Jin-peng, NIE He
doaj  

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Selection of Generator Fault Impedances for Enhancement of Network-Wide Fault Behaviour

, 2003
This paper presents the development and application of a method for illustrating graphically the range of suitable generator designs for achieving a desired performance of a network under either balanced or single line-to-ground fault conditions.
Saha, Tapan K., McDonald, J. D. F.
core  

Selectivity and security of DC microgrid under line-to-ground fault

Electric Power Systems Research, 2018
Abstract Over the recent years, low-voltage dc (LVDC) distribution systems have become increasingly interesting. One of the main problems in their diffusion is the realization of reliable protection systems ensuring selectivity and security to the loads. Several solutions to this problem are studied in the current literature and are mainly focused on
R. Lazzari, L. Piegari, S. Grillo, M. Carminati, E. Ragaini, C. Bossi, E. Tironi   +6 more
openaire   +1 more source

A New Method for Fault Line Selection of Photovoltaic Power Station Collection Lines Based on TEO Energy

Zhongguo dianli
Carrying out rapid fault selection of PV power station collection lines is of great significance to ensure the stable operation of the system. A fault method for PV power station collection lines based on the zero-sequence current gradient Teager energy ...
Ran ZHENG, Jiayi WU, Haoliang DU, Wulue PAN   +3 more
doaj   +1 more source

Fault line selection method for distribution network based on measurement of characteristic atom

Gong-kuang zidonghua, 2017
For problems that fault feature extraction was not enough and fault line selection criterion needs samples with long training time in existing fault line selection methods for distribution network, a fault line selection method for distribution network ...
ZHAO Liang, ZHOU Nuoying, WANG Xiaowei
doaj   +1 more source