Results 51 to 60 of about 395,883 (248)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Parity space-based fault detection for Markovian jump systems [PDF]

, 2009
This article deals with problems of parity space-based fault detection for a class of discrete-time linear Markovian jump systems. A new algorithm is firstly introduced to reduce the computation of mode-dependent redundancy relation parameter matrices ...
Ding, Qiang, Shi, Peng, Zhong, Maiying
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Software fault tree analysis tool user's manual [PDF]

, 1986
The Software Fault Tree Analysis Tool allows the user to interactively modify the graphic representation of a fault tree. This manual describes the user interface of the tool.
Genung, Christi, Leveson, Nancy, Rolandelli, Craig, Shimeall, Timothy J.   +3 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Classical simulation of commuting quantum computations implies collapse of the polynomial hierarchy

, 2010
We consider quantum computations comprising only commuting gates, known as IQP computations, and provide compelling evidence that the task of sampling their output probability distributions is unlikely to be achievable by any efficient classical means ...
Aaronson S., Fenner S., Nielsen M., Papadimitriou C.   +3 more
core   +2 more sources

Regional mapping of the crustal structure in southern California from receiver functions [PDF]

, 2007
Lateral variations of the crustal structure in southern California are determined from receiver function (RF) studies using data from the Southern California Seismic Network broadband stations and Los Angeles Regional Seismic Experiment surveys.
Clayton, R. W., Yan, Z.
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Improving Aircraft Engines Prognostics and Health Management via Anticipated Model-Based Validation of Health Indicators [PDF]

, 2014
The aircraft engines manufacturing industry is subjected to many dependability constraints from certification authorities and economic background. In particular, the costs induced by unscheduled maintenance and delays and cancellations impose to ensure a
LAMOUREUX, Benjamin, MASSÉ, Jean-Rémi, MECHBAL, Nazih   +2 more
core   +6 more sources