Results 81 to 90 of about 15,869 (290)

A novel line selection method of single phase grounding fault suitable for coal mine power network

open access: yes, 2016
For problems that existing fault line selection methods for coal mine power network had low detecting sensitivity and were easily influenced by neutral point operation mode and electric arc at grounding point, characteristics of sequence current and ...
ZHAO Dongqiang   +3 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

A framework and methods for on-board network level fault diagnostics in automobiles [PDF]

open access: yes
A significant number of electronic control units (ECUs) are nowadays networked in automotive vehicles to help achieve advanced vehicle control and eliminate bulky electrical wiring.
Suwatthikul, Jittiwut
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Research of Line Selection Method of Single-phase Grounding Leakage Fault of Coal Mine High-voltage Grid

open access: yesGong-kuang zidonghua, 2012
A new type of line selection method of single-phase grounding leakage fault of coal mine high-voltage grid uses fault diagnosis method of current harmonic, zero-sequence active power method and transient zero-sequence current mutual product sum method to
MA Xing-he   +2 more
doaj  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Research of Fault Line Selection Method of Distribution Network Based on Transient Zero-sequence Energy

open access: yesGong-kuang zidonghua, 2012
For problem of ineffectiveness of traditional line selection methods by use of single feature value caused by complex and random fault borderline, small steady component of fault and reverse phase of instantaneous zero-sequence power when single-phase ...
TIAN Shu, HE Jin-peng, NIE He
doaj  

Selectivity and security of DC microgrid under line-to-ground fault

open access: yesElectric Power Systems Research, 2018
Abstract Over the recent years, low-voltage dc (LVDC) distribution systems have become increasingly interesting. One of the main problems in their diffusion is the realization of reliable protection systems ensuring selectivity and security to the loads. Several solutions to this problem are studied in the current literature and are mainly focused on
R. Lazzari   +6 more
openaire   +1 more source

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