Results 101 to 110 of about 395,883 (248)
The impact of unilateral divorce on crime [PDF]
, 2008 In this paper, we evaluate the impact of unilateral divorce on crime. First, using crime rates from the FBI´s Uniform Crime Report program for the period 1965-1998 and differences in the timing in the introduction of the reform, we find that unilateral
Eugenio Giolito +5 more
core +4 more sources
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Differential Protection of Distribution Network Based on VMD and Duffing Oscillator
Zhongguo dianliThe distribution network is grounded through arc suppression coil. When a single-phase grounding fault occurs, the faulting characteristics are often weak and unobvious, which makes it difficult to accurately locate the fault line.
Jianbao ZHANG, Lei WANG, Weijian JIANG
doaj +1 more source
Sir Syed University Research Journal of Engineering and Technology, 2023 HVDC transmission has become a cost-effective option for transferring high voltage over greater distances. Protecting an HVDC transmission line is more challenging than protecting an AC transmission line due to its low impedance and absence of zero ...
Hasnain Raza chandio, Aslam Pervez Memon
doaj
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Faulty feeder selection based on improved Hough transform in resonant grounded distribution networks
International Journal of Electrical Power & Energy SystemsDue to the weak fault characteristics and inaccurate fault line selection during high impedance faults, this paper proposes a new method for fault line selection in resonant grounded distribution networks based on improved Hough transform.
Xiaowei Wang +5 more
doaj +1 more source