Results 101 to 110 of about 22,911 (308)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Fault Injection Evaluation with Statistical Analysis

Transactions on Cryptographic Hardware and Embedded Systems
A critical aspect of securing cryptographic hardware is their resistance to Fault Injection (FI) attacks, which involve the successful injection of faults into the system in operation. Specifically, a hardware design must be resilient to wellestablished
Felix Uhle, Nicolai Müller, Amir Moradi
doaj   +1 more source

1-ohm Impedance Criterion for Diagnosis of Single-Phase Ground Fault of Transmission Line

IEEE Access
The transition resistance during single-phase grounding faults in transmission lines is closely related to the fault cause. Quickly determining the cause of the fault through the transition resistance value and taking targeted measures to restore the ...
Xueming Zhou, Xiankang Wang, Yao Yao, Zhiqiang Feng, Zixuan Hu, Jianjin Fu, Zijian Li   +6 more
doaj   +1 more source

Fault location for nonlinear resistive circuits

Electronics Letters, 1984
The letter deals with fault location in nonlinear resistive circuits taking the design tolerances of the nonfaulty circuit parameters into consideration. The method described is based on measurements of node voltages at a single test. It belongs to the class of topological methods, and two-terminal as well as m-terminal elements are permitted.
J. Rutkowski, A. Macura
openaire   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Evaluating the impact of superconducting fault current limiters on distribution network protection schemes

, 2011
Rising fault levels are becoming increasingly problematic in the UK distribution network, with large sections of the network operating near to its designed fault level capability.
Burt, Graeme M, Emhemed, Abdullah, Kincaid, Jennifer, Abdulhadi, Ibrahim   +3 more
core  

Fault-Resistant Partitioning of Secure CPUs for System Co-Verification against Faults

IACR Transactions on Cryptographic Hardware and Embedded Systems
Fault injection attacks are a serious threat to system security, enabling attackers to bypass protection mechanisms or access sensitive information. To evaluate the robustness of CPU-based systems against these attacks, it is essential to analyze the consequences of the fault propagation resulting from the complex interplay between the software and the
Simon Tollec, Vedad Hadzic, Pascal Nasahl, Mihail Asavoae, Roderick Bloem, Damien Couroussé, Karine Heydemann, Mathieu Jan, Stefan Mangard   +8 more
openaire   +5 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Novel fault current-limiting scheme for MMC-based flexible HVDC system

The Journal of Engineering, 2019
Currently, the flexible direct current transmission technique becomes a research focus around the world, and be applied in power engineering projects gradually.
Yueyang Ma, Guibin Zou, Shenglan Song, Jianbao Guo, Zhanjun Gao   +4 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source