Results 61 to 70 of about 19,022 (315)
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Review of Fault-Tolerant Control Methods for Suspension Systems: From Road Vehicles to Maglev Trains
MathematicsRoad vehicles and maglev trains have garnered significant attention, with their suspension systems being crucial for safe and stable performance. However, these systems can be compromised by faults such as sensor and actuator failures, posing risks to ...
Fei Ni +5 more
doaj +1 more source
A new fault tolerant control scheme for non‐linear systems by T‐S fuzzy model approach
IET Control Theory & Applications, 2021 This paper is concerned with the problem of fault tolerant control for non‐linear systems with sensor faults based on the T‐S fuzzy model approach. First, a fault estimation (FE) observer with L∞ technique is designed to estimate the fault.
Yue Wu +3 more
doaj +1 more source
, 2012 Modular generator and converter topologies are being pursued for large offshore wind turbines to achieve fault tolerance and high reliability. A centralized controller presents a single critical point of failure which has prevented a truly modular and ...
Finney, Stephen J. +4 more
core +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Adaptive Integral-Type Terminal Sliding Mode Fault Tolerant Control for Spacecraft Attitude Tracking
IEEE Access, 2019 In this paper, the attitude tracking control for a spacecraft system based on a novel adaptive integral-type terminal sliding mode fault-tolerant control strategy is investigated.
Zhao Wang, Qi Li, Shurong Li
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Design and Validation of a Fault Tolerant Fuzzy Control for a Wind Park High–Fidelity Simulator
, 2021 To enhance both the safety and the efficiency of offshore wind park systems, faults must be accommodated in their earlier occurrence, in order to avoid costly unplanned maintenance.
Simani S., Turhan C., Farsoni S
core +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Flatness-based fault tolerant control
Dyna, 2014 Este artículo presenta un método de control tolerante a fallas para sistemas no lineales planos. Las propiedades intrínsecas d e los sistemas planos generan redundancia analítica y permiten calcular todos los estados y las entradas de control del sistema.
César Martínez-Torres +4 more
doaj