Results 1 to 10 of about 153,756 (258)

Fc receptors act as innate immune receptors during infection? [PDF]

Frontiers in Immunology, 2023
Innate immunity constitutes the first nonspecific immunological line of defense against infection. In this response, a variety of mechanisms are activated: the complement system, phagocytosis, and the inflammatory response.
Chaimaa Laassili, Fatiha Ben El Hend, Riad Benzidane, Loubna Oumeslakht, Abdel-Ilah Aziz, Rachid El Fatimy, Armand Bensussan, Armand Bensussan, Armand Bensussan, Sanae Ben Mkaddem   +9 more
doaj   +2 more sources

Inside-Out Control of Fc-Receptors [PDF]

Frontiers in Immunology, 2019
Receptors recognizing the Fc-part of immunoglobulins (FcR) are important in the engagement of phagocytes with opsonized micro-organisms, but they also play a major role in the pathogenesis of chronic inflammatory diseases. Different FcRs are specifically
Leo Koenderman
doaj   +2 more sources

Changes in the Interaction Properties of Antibodies with Fc Receptors upon Binding to Target Antigens [PDF]

Biosensors
The interaction of therapeutic antibodies with Fc receptors is an important property that is actively modified to improve pharmacokinetic profiles and optimize antibody-dependent mechanisms of action.
Artem S. Grevtsev, Anton A. Kommer, Irina S. Zelmanchuk, Andrei S. Avdiushkin, Elizaveta O. Ermolaeva, Aleksandr A. Tiulin, Darya O. Chernyshova, Alexandra D. Azarian, Alexandr A. Gordeev, Aleksey K. Misorin   +9 more
doaj   +2 more sources

Selective decoupling of IgG1 binding to viral Fc receptors restores antibody-mediated NK cell activation against HCMV [PDF]

Cell Reports
Summary: Antibodies binding cell-surface antigens to activate cellular immunity are an important mechanism of anti-viral protection, yet antibodies targeting cells infected by human cytomegalovirus (HCMV) exhibit limited efficacy.
Ahlam N. Qerqez, Katja Hoffmann, Alison G. Lee, Sumit Pareek, Kelli Hager, Akaash K. Mishra, George Delidakis, Kirsten Bentley, Lauren Kerr-Jones, Mica Cabrera, Truong Nguyen, Rebecca L. Göttler, Amjad Chowdhury, Philipp L. Kolb, Hartmut Hengel, George Georgiou, Jason S. McLellan, Richard J. Stanton, Annalee W. Nguyen, Jennifer A. Maynard   +19 more
doaj   +3 more sources

Fc receptors for immunoglobulins and their appearance during vertebrate evolution. [PDF]

PLoS ONE, 2014
Receptors interacting with the constant domain of immunoglobulins (Igs) have a number of important functions in vertebrates. They facilitate phagocytosis by opsonization, are key components in antibody-dependent cellular cytotoxicity as well as ...
Srinivas Akula, Sayran Mohammadamin, Lars Hellman   +2 more
doaj   +2 more sources

Corrigendum: Inside-Out Control of Fc-Receptors [PDF]

Frontiers in Immunology, 2019
Leo Koenderman
doaj   +2 more sources

Editorial: Roles of Fc Receptors in Disease and Therapy [PDF]

Frontiers in Immunology, 2020
Latha P. Ganesan, Mark S. Cragg, Gestur Vidarsson   +2 more
doaj   +2 more sources

Biophysical Evaluation of Rhesus Macaque Fc Gamma Receptors Reveals Similar IgG Fc Glycoform Preferences to Human Receptors

Frontiers in Immunology, 2021
Rhesus macaques are a common non-human primate model used in the evaluation of human monoclonal antibodies, molecules whose effector functions depend on a conserved N-linked glycan in the Fc region.
Andrew R. Crowley, Nana Yaw Osei-Owusu, Gillian Dekkers, Wenda Gao, Manfred Wuhrer, Diogo M. Magnani, Keith A. Reimann, Seth H. Pincus, Seth H. Pincus, Gestur Vidarsson, Margaret E. Ackerman, Margaret E. Ackerman   +11 more
doaj   +1 more source

Fc-engineered antibodies with immune effector functions completely abolished.

PLoS ONE, 2021
Elimination of the binding of immunoglobulin Fc to Fc gamma receptors (FcγR) is highly desirable for the avoidance of unwanted inflammatory responses to therapeutic antibodies and fusion proteins.
Ian Wilkinson, Stephen Anderson, Jeremy Fry, Louis Alex Julien, David Neville, Omar Qureshi, Gary Watts, Geoff Hale   +7 more
doaj   +1 more source

The Diverse Functions of the Ubiquitous Fcγ Receptors and Their Unique Constituent, FcRγ Subunit

Pathogens, 2020
Fc gamma receptors (FcγRs) are widely expressed on a variety of immune cells and play a myriad of regulatory roles in the immune system because of their structural diversity.
Thamer A. Hamdan, Philipp A. Lang, Karl S. Lang   +2 more
doaj   +1 more source