Results 151 to 160 of about 2,051 (177)

Novel FCN2 Variants and Haplotypes are Associated with Rheumatic Heart Disease

DNA and Cell Biology, 2021
Ficolins are pattern recognition molecules that are involved in innate immune defense. Ficonin-2 (FCN2) has a specific affinity for lipoteichoic acid present in the cell wall of Streptococcus pyogenes, an etiological agent for rheumatic heart disease ...
Nizamuddin, Kumarasamy Thangaraj
exaly   +5 more sources

Analysis of selected FCN2 polymorphismsin patients with chronic tonsillitis

Polski Przegląd Otorynolaryngologiczny, 2023
Introduction: Chronic tonsillitis is a disease with an incompletely elucidated etiopathogenesis. Can be considered that the main cause of chronic inflammation of the tonsils is bacterial and viral infections and autoimmune reactions.
K. Gołąbek, Dorota Hudy, Jadwiga Gaździcka, Katarzyna Miśkiewicz-Orczyk, Natalia Zięba, Olga Karłowska-Bijak, Agata Świętek, M. Asman, Krzysztof Biernacki, Maciej Misiołek, J. Strzelczyk   +10 more
semanticscholar   +3 more sources

FCN2 inhibits epithelial–mesenchymal transition-induced metastasis of hepatocellular carcinoma via TGF-β/Smad signaling

Cancer Letters, 2016
Hepatocellular carcinoma (HCC) is currently still a major cause of cancer-related deaths. Identifying early metastatic biomarkers and therapeutic targets for HCC is of great importance. Emerging evidence suggest that epithelial-mesenchymal transitions (EMTs) play important roles in tumor metastasis and recurrence.
Tongsen Zheng, Jiabei Wang, Changming Xie   +2 more
exaly   +4 more sources

MBL2 and FCN2 gene polymorphisms in a cohort of Italian children with rheumatic fever: A case–control study

Seminars in Arthritis and Rheumatism, 2017
Mannose-binding lectins and human ficolins are pattern-recognition proteins involved in innate immunity. A role for MBL2 and FCN2 gene polymorphisms in the pathogenesis of recurrent severe streptococcal infections and rheumatic carditis has been suggested.The aim of this study is to evaluate the presence of MBL2 and FCN2 gene polymorphisms (SNPs) in ...
Caterina Di Battista, Leonardo Carlucci, Michela Balsamo   +2 more
exaly   +6 more sources

Evolution of the FCN2 promoter polymorphism

Molecular Immunology, 2011
A. Boldt, C. Grisbach, J. Kun, I. Messias-Reason   +3 more
exaly   +3 more sources

Structural, electronic and vibrational properties of N,N′-1H,1H-perfluorobutyl dicyanoperylenecarboxydiimide (PDI-FCN2) crystal

Journal of Chemical Physics, 2013
We present a theoretical and experimental investigation of the crystalline structure of N,N′-1H,1H-perfluorobutyl dicyanoperylenecarboxydiimide (PDI-FCN2) that has been deduced combining experimental XRD data, obtained from powders, with global-optimization algorithms which allow to identify Bravais lattice, primitive cell parameters, and space group ...
Renato Colle, Giuseppe Grosso, A Cassinese   +2 more
exaly   +6 more sources

The relationship between FCN2 genotypes and serum ficolin-2 (L-ficolin) protein concentrations from a large cohort of neonates

Human Immunology, 2013
The human FCN2 gene codes for ficolin-2 (L-ficolin), a major pattern recognition molecule and activator of the lectin pathway of complement. Seven single nucleotide polymorphisms of this gene were investigated in a large series of cord blood DNA samples.
Misao Matsushita, Iwona Domzalska-Popadiuk, Maciej Cedzynski   +2 more
exaly   +4 more sources

Association of FCN2 gene rs3124954 and STAT4 gene rs7582694 polymorphisms with juvenile onset systemic lupus erythematosus and lupus nephritis in a sample of Egyptian children

Gene Reports, 2020
Background Juvenile onset SLE (joSLE) is multifactorial autoimmune inflammatory disease with multiple genetic liabilities. Lupus nephritis (LN) is one of the major complications of SLE.
I. Ashmawy, D. El-Lebedy, Eman Awadallah, Huda Marzouk, Y. Farag, A. Ibrahim   +5 more
semanticscholar   +2 more sources

The prevalence of the variants of the L-ficolin gene (FCN2) in the arctic populations of East Siberia [PDF]

Immunogenetics, 2017
L-ficolin encoded by FCN2 gene is a crucial factor of defence against infection in humans. We studied the prevalence of the two common variants (rs17549193 and rs7851696) in aboriginal and alien populations of the Taymyr-Dolgan-Nenets region of Krasnoyarskiy Kray, East Siberia, Russia (Nenets, Dolgans, Nganasans, Russians).
M. Smolnikova, M. Freidin, S. Tereshchenko   +2 more
semanticscholar   +4 more sources

Ficolin-2 levels and genetic polymorphisms of FCN2 in malaria.

Human Immunology, 2011
Human ficolin-2 (L-ficolin; FCN2) is a serum protein binding to sugar moieties of different human micro-pathogens forcing phagocytosis. Here, we investigate the clinical significance of FCN2 in African children with either mild or severe malaria (n = 130 and n = 108, respectively) from Gabon by analyzing three promoter SNPs (-986G>A, -602G>A, and -4A>G)
I. Faik, S. I. Oyedeji, Z. Idris, I. D. de Messias-Reason, B. Lell, P. Kremsner, J. Kun   +6 more
semanticscholar   +3 more sources