Results 81 to 90 of about 2,051 (177)

Discovery of Endothelial–Monocyte Crosstalk in Ischemic‐Reperfusion Injury Following Liver Transplantation Based on Integration of Single‐Cell RNA and Transcriptome RNA Sequencing

Journal of Cellular and Molecular Medicine, Volume 29, Issue 4, February 2025.
ABSTRACT Hepatic ischemia/reperfusion injury (IRI) commonly complicates liver transplantation (LT). However, the precise mechanisms underlying hepatic IRI remain incompletely understood. We acquired single‐cell RNA sequencing (scRNA‐seq) and transcriptome RNA sequencing data of LT patients from the GEO database.
Chao Sun, Li Li, Dan Li, Zhengxin Wang
wiley   +1 more source

Expression profiling of genes related to asthma exacerbations [PDF]

, 2009
Background Asthma is a chronic airway inflammatory disease; however, the molecular mechanisms that underlie asthma exacerbation are only partially understood.Objective To identify gene expression signatures that reflect the acute exacerbation of asthma ...
Aoki T., Arinami T., Hirata K., Ichikawa K., Matsumoto Y., Noguchi E., Ochiai K., Okada M., Shibasaki M., Sumazaki R., 有波 忠雄, 野口 惠美子, 青木 健, 須磨崎 亮   +13 more
core   +1 more source

Genetic mannose binding lectin deficiency is associated with airway microbiota diversity and reduced exacerbation frequency in COPD [PDF]

, 2017
BACKGROUND: In cystic fibrosis and bronchiectasis, genetic mannose binding lectin (MBL) deficiency is associated with increased exacerbations and earlier mortality; associations in COPD are less clear.
Adrian Hapca, Aguirre, Albert, Alison J Dicker, Andrew J Cassidy, Aydemir, Boixeda, Brusselle, Colin N A Palmer, Elizabeth Furrie, Gill Brady, Gisli G Einarsson, J Stuart Elborn, James D Chalmers, Mandal, Megan L Crichton, Roger Tavendale, Sara E Marshall, Stuart Schembri   +18 more
core   +2 more sources

Cardiac and Digestive Forms of Chagas Disease: An Update on Pathogenesis, Genetics, and Therapeutic Targets

Mediators of Inflammation, Volume 2025, Issue 1, 2025.
Chagas disease, caused by the protozoan parasite Trypanosoma cruzi (T. cruzi), is a neglected disease affecting around 6 million people, with no effective antiparasitic drugs or vaccines. About 40% of Chagas disease patients develop symptomatic forms in the chronic phase of infection, chronic Chagas cardiomyopathy (CCC) or digestive forms like ...
Amanda Farage Frade, Hélléa Guérin, Joao Paulo Silva Nunes, Luiz Felipe Souza e Silva, Vinicius Moraes de Paiva Roda, Rafael Pedro Madeira, Pauline Brochet, Pauline Andrieux, Jorge Kalil, Christophe Chevillard, Edecio Cunha-Neto, Alessandro Trentini   +11 more
wiley   +1 more source

Multivariable control theory applied to hierarchial attitude control for planetary spacecraft [PDF]

Multivariable control theory is applied to the design of a hierarchial attitude control system for the CARD space vehicle. The system selected uses reaction control jets (RCJ) and control moment gyros (CMG). The RCJ system uses linear signal mixing and a
Boland, J. S., III, Russell, D. W.
core   +1 more source

Viral expression and molecular profiling in liver tissue versus microdissected hepatocytes in hepatitis B virus - associated hepatocellular carcinoma. [PDF]

, 2014
Background: The molecular mechanisms whereby hepatitis B virus (HBV) induces hepatocellular carcinoma (HCC) remain elusive. We used genomic and molecular techniques to investigate host-virus interactions by studying multiple areas of the same liver from
Becker S, Brown C R, Diaz G, Emmert-Buck M, Engle R E, Farci, P, Govindarajan S, Hanson J C, Kabat J, Kew M, Kleiner D E, Lai J P, Melis M, Mogavero G, Rodriguez-Canales J, Tice A, Zamboni F   +16 more
core   +1 more source

Insectivorous birds and bats outperform ants in the top‐down regulation of arthropods across strata of a Japanese temperate forest

Journal of Animal Ecology, Volume 93, Issue 11, Page 1622-1638, November 2024.
Our study is the first to experimentally investigate the independent and combined impacts of bats, birds and ants on arthropod densities and subsequent herbivory damage across the canopy and understorey temperate forest layers. We found no vertical gradient in top‐down control importance in the forest.
Elise Sivault, Jan Kollross, Leonardo Re Jorge, Sam Finnie, David Diez‐Méndez, Sara Fernandez Garzon, Heveakore Maraia, Jan Lenc, Martin Libra, Masashi Murakami, Tatsuro Nakaji, Masahiro Nakamura, Rachakonda Sreekar, Legi Sam, Tomokazu Abe, Matthias Weiss, Katerina Sam   +16 more
wiley   +1 more source

Circulating small non‐coding RNAs are associated with the insulin‐resistant and obesity‐related type 2 diabetes clusters

Diabetes, Obesity and Metabolism, Volume 26, Issue 10, Page 4375-4385, October 2024.
Abstract Aim To uncover differences in small non‐coding RNAs (sncRNAs) in individuals with type 2 diabetes (T2D) categorized into five clusters based on individual characteristics, which may aid in the identification of those prone to rapid progression. Materials and Methods In the Hoorn Diabetes Care System (DCS) cohort, participants were clustered by
Juliette A. de Klerk, Joline W. J. Beulens, Roel Bijkerk, Anton Jan van Zonneveld, Petra J. M. Elders, Leen M. ’t Hart, Roderick Slieker   +6 more
wiley   +1 more source

Allelic lineages of the ficolin genes (FCNs) are passed from ancestral to descendant primates.

PLoS ONE, 2011
The ficolins recognize carbohydrates and acetylated compounds on microorganisms and dying host cells and are able to activate the lectin pathway of the complement system.
Tina Hummelshøj, Janna Nissen, Lea Munthe-Fog, Claus Koch, Mads Frost Bertelsen, Peter Garred   +5 more
doaj   +1 more source

An interpretable machine learning‐based cerebrospinal fluid proteomics clock for predicting age reveals novel insights into brain aging

Aging Cell, Volume 23, Issue 9, September 2024.
We sought to understand how cerebrospinal fluid (CSF) changes with age to inform the development of brain aging‐related disease mechanisms and identify potential anti‐aging therapeutic targets. To do so we developed a machine learning clock that uses CSF proteomics to predict the chronological age of individuals.
Justin Melendez, Yun Ju Sung, Miranda Orr, Andrew Yoo, Suzanne Schindler, Carlos Cruchaga, Randall Bateman   +6 more
wiley   +1 more source