Results 61 to 70 of about 2,051 (177)

Association Study of Mannose-Binding Lectin Levels and Genetic Variants in Lectin Pathway Proteins with Susceptibility to Age-Related Macular Degeneration: A Case-Control Study.

PLoS ONE, 2015
BackgroundIn age-related macular degeneration (AMD) the complement system is thought to be activated by chronic oxidative damage with genetic variants identified in the alternative pathway as susceptibility factors. However, the involvement of the lectin
Michael Osthoff, Melinda M Dean, Paul N Baird, Andrea J Richardson, Mark Daniell, Robyn H Guymer, Damon P Eisen   +6 more
doaj   +1 more source

DOTA: A Large-scale Dataset for Object Detection in Aerial Images [PDF]

, 2018
Object detection is an important and challenging problem in computer vision. Although the past decade has witnessed major advances in object detection in natural scenes, such successes have been slow to aerial imagery, not only because of the huge ...
Bai, Xiang, Belongie, Serge, Datcu, Mihai, Ding, Jian, Luo, Jiebo, Pelillo, Marcello, Xia, Gui-Song, Zhang, Liangpei, Zhu, Zhen   +8 more
core   +2 more sources

Association of Ficolin-3 with Severity and Outcome of Chronic Heart Failure [PDF]

, 2013
BACKGROUND: Inflammatory mechanisms involving complement activation has been shown to take part in the pathophysiology of congestive heart failure, but the initiating mechanisms are unknown. We hypothesized that the main initiator molecules of the lectin
A Krarup, AJ Nauta, Alice Gustavsen, Arne Yndestad, BJ Wrigley, C Honore, C Honore, CA Ogden, CC Wang, Christen P. Dahl, DJ Clark, E Gout, E Hein, Erik T. Askevold, G Fust, George Füst, GH Oliveira, HJ Kim, István Karádi, JJ McMurray, JT Bay, L Munthe-Fog, L Munthe-Fog, L Munthe-Fog, Lars Gullestad, Lea Munthe-Fog, Lívia Jánoskuti, M Lund Jensen, Mikkel-Ole Skjoedt, MJ Walport, N Imai, O Zimmermann, P Aukrust, P Garred, P Garred, P Garred, Peter Garred, Pål Aukrust, RA Kaslow, Robert B. Sim, RS Whelan, RX Li, S Kostin, T Gombos, T Hummelshoj, Thor Ueland, Timea Gombos, Tom E. Mollnes, TP Zwaka, Zoltan Pozsonyi, Zoltán Prohászka, Zsolt Förhécz   +51 more
core   +3 more sources

A Rare Genetic Defect of MBL2 Increased the Risk for Progression of IgA Nephropathy

Frontiers in Immunology, 2019
The aim of this study was to investigate the association between lectin pathway-related genetic variations and progression in IgA nephropathy. Biopsy-proven IgAN patients with eGFR ≥15 ml/min/1.73 m2 at baseline and a minimum follow-up of 12-months were ...
Yan Ouyang, Li Zhu, Manman Shi, Shuwen Yu, Yuanmeng Jin, Zhaohui Wang, Jun Ma, Meng Yang, Xiaoyan Zhang, Xiaoxia Pan, Hong Ren, Weiming Wang, Hong Zhang, Jingyuan Xie, Nan Chen   +14 more
doaj   +1 more source

Genetic variants of innate immune receptors and infections after liver transplantation. [PDF]

, 2017
Infection is the leading cause of complication after liver transplantation, causing morbidity and mortality in the first months after surgery. Allograft rejection is mediated through adaptive immunological responses, and thus immunosuppressive therapy is
Cervera, Carlos, Lozano Soto, Francisco, Moreno Camacho, Ma. Asunción, Navasa, Miquel, Sanclemente, Gemma   +4 more
core   +1 more source

Progressive multifocal leukoencephalopathy genetic risk variants for pharmacovigilance of immunosuppressant therapies

Frontiers in Neurology, 2022
BackgroundProgressive multifocal leukoencephalopathy (PML) is a rare and often lethal brain disorder caused by the common, typically benign polyomavirus 2, also known as JC virus (JCV).
Eli Hatchwell, Edward B. Smith, Shapour Jalilzadeh, Christopher D. Bruno, Yassine Taoufik, Houria Hendel-Chavez, Roland Liblau, Roland Liblau, David Brassat, David Brassat, Guillaume Martin-Blondel, Guillaume Martin-Blondel, Heinz Wiendl, Nicholas Schwab, Irene Cortese, Maria Chiara Monaco, Luisa Imberti, Ruggero Capra, Jorge R. Oksenberg, Jacques Gasnault, Bruno Stankoff, Todd A. Richmond, David M. Rancour, Igor J. Koralnik, Barbara A. Hanson, Eugene O. Major, Christina R. Chow, Peggy S. Eis   +27 more
doaj   +1 more source

BiGraph‐DTA: Predicting drug–target interactions of hepatoprotective agents with graph convolutional networks

Quantitative Biology, Volume 14, Issue 1, March 2026.
Abstract Predicting drug–target affinity (DTA) is critical for discovering and developing hepatoprotective agents that can prevent and treat liver diseases. In this study, we propose BiGraph‐DTA, a new predictive model for identifying DTA score prediction for hepatoprotective compounds by combining graph convolutional networks and bidirectional long ...
Arief Sartono, Bambang Riyanto Trilaksono, Sophi Damayanti, Anto Satriyo Nugroho, Firdayani Firdayani   +4 more
wiley   +1 more source

Associations of ficolins and mannose-binding lectin with acute myeloid leukaemia in adults

Scientific Reports, 2020
We investigated clinical associations of ficolins and mannose-binding lectin (MBL) in 157 patients suffering from acute myeloid leukaemia (AML). Concentrations of ficolin-1, ficolin-2, ficolin-3 and MBL (before chemotherapy) in serum were determined as ...
Anna Sokołowska, Anna S. Świerzko, Gabriela Gajek, Aleksandra Gołos, Mateusz Michalski, Mateusz Nowicki, Agnieszka Szala-Poździej, Anna Wolska-Washer, Olga Brzezińska, Agnieszka Wierzbowska, Krzysztof Jamroziak, Marek L. Kowalski, Steffen Thiel, Misao Matsushita, Jens C. Jensenius, Maciej Cedzyński   +15 more
doaj   +1 more source

Serum Proteomic Profile Based on the TGF‐β Pathway Stratifies Risk of Hepatocellular Carcinoma

Liver International, Volume 45, Issue 10, October 2025.
ABSTRACT Background Hepatocellular carcinoma (HCC) is the third leading cause of cancer‐related deaths, primarily due to late‐stage diagnosis. In this multicenter study, our goal is to identify functional biomarkers that stratify the risk of HCC in patients with cirrhosis (CP) for early diagnosis.
Xiyan Xiang, Kirti Shetty, Herbert Yu, Bibhuti Mishra, Linda L. Wong, Xianghong Jasmine Zhou, Sanjaya K. Satapathy, James M. Crawford, Patricia S. Latham, Steven‐Huy Han, Brandon Mathew, Nabil N. Dagher, Lawrence Lau, Fellanza Cacaj, Anil K. Vegesna, Srinivasan Dasarathy, Aiwu R. He, Hai Huang, Richard L. Amdur, Lopa Mishra   +19 more
wiley   +1 more source

From multi‐omics to precision medicine in intracranial aneurysm: Biomarker discovery and multimodal integration

Interdisciplinary Medicine, Volume 3, Issue 5, September 2025.
This review explores intracranial aneurysm biomarker discovery through multi‐omics. It reveals key genes, proteins, and metabolites, and shows how machine‐learning‐based multi‐modal integration may aid diagnosis and treatment. Abstract Despite extensive research, currently, no biomarkers are available for clinical use in intracranial aneurysm (IA ...
Jiaxin Zhang, Yufei Yang, Bingxu Chen, Yanmeng Zhao, Haitao Sun   +4 more
wiley   +1 more source