Results 51 to 60 of about 2,051 (177)
Nature Communications, 2023 Sensitive and reliable protein biomarkers are needed to predict disease trajectory and personalize treatment strategies for multiple sclerosis (MS). Here, we use the highly sensitive proximity-extension assay combined with next-generation sequencing ...
Julia Åkesson +14 more
doaj +1 more source
Biomedicines, 2023 Aging causes alterations in body composition. Specifically, visceral fat mass increases with age and is associated with age-related diseases. The pathogenic potential of visceral fat accumulation has been associated with its anatomical location and ...
Diogo de Moraes +9 more
doaj +1 more source
Upregulation of Early and Downregulation of Terminal Pathway Complement Genes in Sbcutaneous Adipose Tissue and Adipocytes in Acquired Obesity [PDF]
, 2017 Inflammation is an important mediator of obesity-related complications such as the metabolic syndrome but its causes and mechanisms are unknown. As the complement system is a key mediator of inflammation, we studied whether it is activated in acquired ...
Hakkarainen, Antti +14 more
core +1 more source
Nephrology Dialysis Transplantation, 2011 Mannose-binding lectin (MBL) and ficolin-2 (FCN) are activators of the lectin pathway of complement and act as primary defences against infection. Single-nucleotide polymorphisms (SNPs) in the MBL2 and FCN2 genes influence the functionality of the proteins.
S. Meijvis +9 more
semanticscholar +3 more sources
Frontiers in Aging Neuroscience, 2018 Background: Blood biomarkers may aid in recruitment to clinical trials of Alzheimer’s disease (AD) modifying therapeutics by triaging potential trials participants for amyloid positron emission tomography (PET) or cerebrospinal fluid (CSF) Aβ and tau ...
Sarah Westwood +30 more
doaj +1 more source
Frontiers in Genetics, 2022 Objective: Ficolin (FCN) family proteins are part of the innate immune system, play a role as recognition molecules in the complement system, and are associated with tumor development.
Liang Sun +7 more
doaj +1 more source
Extracellular Vesicles in Hepatobiliary Malignancies [PDF]
, 2018 Primary hepatobiliary malignancies include a heterogeneous group of cancers with dismal prognosis, among which hepatocellular carcinoma (HCC), cholangiocarcinoma (CCA), and hepatoblastoma (HB) stand out.
Aranburu, Aitziber +6 more
core +2 more sources
Exosome‐Mediated Lectin Pathway and Resistin‐MIF‐AA Metabolism Axis Drive Immune Dysfunction in Immune Thrombocytopenia (Adv. Sci. 10/2025) [PDF]
Advanced scienceImmune Thrombocytopenia The exosomes from patients with immune thrombocytopenia induce complement system activation through delivery of FCN2 and MBL2, triggering platelet destruction and hyperactivation of immune cells. The hyperactivated immune cells exploit resistin, MIF and arachidonic acid metabolism to enforce aberrant immune responses‐ akin to ...
Jin Li +21 more
europepmc +2 more sources
PU.1 drives specification of pluripotent stem cell-derived endothelial cells to LSEC-like cells
Cell Death and Disease, 2021 To date, there is no representative in vitro model for liver sinusoidal endothelial cells (LSECs), as primary LSECs dedifferentiate very fast in culture and no combination of cytokines or growth factors can induce an LSEC fate in (pluripotent stem cell ...
Jonathan De Smedt +13 more
doaj +1 more source
CoupleNet: Coupling Global Structure with Local Parts for Object Detection [PDF]
, 2017 The region-based Convolutional Neural Network (CNN) detectors such as Faster R-CNN or R-FCN have already shown promising results for object detection by combining the region proposal subnetwork and the classification subnetwork together.
Lu, Hanqing +5 more
core +2 more sources